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Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 18005, updated on 1-Mar-2024

Summary

Official Symbol
Nek2provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 2provided by MGI
Primary source
MGI:MGI:109359
See related
Ensembl:ENSMUSG00000026622 AllianceGenome:MGI:109359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein kinase activity. Acts upstream of or within several processes, including blastocyst development; mitotic nuclear division; and negative regulation of DNA binding activity. Located in condensed nuclear chromosome; midbody; and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 25.4), CNS E11.5 (RPKM 10.9) and 15 other tissues See more
Orthologs
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Genomic context

See Nek2 in Genome Data Viewer
Location:
1 H6; 1 96.94 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191553622..191565161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191821449..191833049)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene predicted gene, 26203 Neighboring gene predicted gene, 20203 Neighboring gene STARR-positive B cell enhancer ABC_E1580 Neighboring gene STARR-positive B cell enhancer ABC_E4409 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03441 Neighboring gene STARR-seq mESC enhancer starr_03442 Neighboring gene RIKEN cDNA 1700034H15 gene Neighboring gene STARR-positive B cell enhancer ABC_E2598 Neighboring gene solute carrier family 30 (zinc transporter), member 1 Neighboring gene predicted gene, 53230

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in centrosome separation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic centrosome separation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase Nek2
Names
NIMA - related expressed kinase 2
NIMA-related expressed kinase 2
NIMA-related kinase 2
Nek2 kinase
never in mitosis A-related kinase 2
nimA-related protein kinase 2
NP_001407321.1
NP_001407322.1
NP_001407323.1
NP_035022.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420392.1NP_001407321.1  serine/threonine-protein kinase Nek2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114603
    UniProtKB/TrEMBL
    Q6PFG1
  2. NM_001420393.1NP_001407322.1  serine/threonine-protein kinase Nek2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114603
    UniProtKB/TrEMBL
    Q6PFG1
  3. NM_001420394.1NP_001407323.1  serine/threonine-protein kinase Nek2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114603
    UniProtKB/TrEMBL
    Q8BP64
  4. NM_010892.4NP_035022.2  serine/threonine-protein kinase Nek2 isoform 1

    See identical proteins and their annotated locations for NP_035022.2

    Status: VALIDATED

    Source sequence(s)
    AC114603
    Consensus CDS
    CCDS15623.1
    UniProtKB/Swiss-Prot
    O35942, O35959, Q3TPD7
    UniProtKB/TrEMBL
    Q6PFG1
    Related
    ENSMUSP00000027931.8, ENSMUST00000027931.8
    Conserved Domains (2) summary
    smart00220
    Location:8271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    191553622..191565161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)