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MSN moesin [ Homo sapiens (human) ]

Gene ID: 4478, updated on 5-Apr-2020

Summary

Official Symbol
MSNprovided by HGNC
Official Full Name
moesinprovided by HGNC
Primary source
HGNC:HGNC:7373
See related
Ensembl:ENSG00000147065 MIM:309845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL70; IMD50
Summary
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 147.3), appendix (RPKM 142.6) and 24 other tissues See more
Orthologs

Genomic context

See MSN in Genome Data Viewer
Location:
Xq12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (65588382..65741931)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64808257..64961793)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1 Neighboring gene uncharacterized LOC107985679 Neighboring gene Nanog homeobox pseudogene 9 Neighboring gene eukaryotic translation termination factor 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of moesin (MSN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Association and clustering of CD4-CXCR4 induced by HIV-1 gp120 requires moesin-mediated anchoring of actin in the plasma membrane PubMed
env Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation PubMed
env Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with ezrin-radixin-moesin proteins at polarized HIV-1 assembly sites in human T cells PubMed
gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
Vpr vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with moesin (MSN) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell aggregation IDA
Inferred from Direct Assay
more info
PubMed 
T cell migration IDA
Inferred from Direct Assay
more info
PubMed 
T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to testosterone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunological synapse formation IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
leukocyte cell-cell adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
leukocyte migration IEP
Inferred from Expression Pattern
more info
PubMed 
membrane to membrane docking IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cellular protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of early endosome to late endosome transport IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to early endosome IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of organelle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
blood microparticle HDA PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm HDA PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
invadopodium IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 
uropod IEA
Inferred from Electronic Annotation
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
moesin
Names
epididymis luminal protein 70
membrane-organizing extension spike protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012516.1 RefSeqGene

    Range
    5011..79283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002444.3NP_002435.1  moesin

    See identical proteins and their annotated locations for NP_002435.1

    Status: REVIEWED

    Source sequence(s)
    BC017293, CN386296, M69066
    Consensus CDS
    CCDS14382.1
    UniProtKB/Swiss-Prot
    P26038
    UniProtKB/TrEMBL
    V9HWC0
    Related
    ENSP00000353408.5, ENST00000360270.7
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347577
    ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    65588382..65741931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262269.2XP_005262326.1  moesin isoform X2

    See identical proteins and their annotated locations for XP_005262326.1

    Conserved Domains (3) summary
    smart00295
    Location:8207
    B41; Band 4.1 homologues
    cd13194
    Location:201297
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:348578
    ERM; Ezrin/radixin/moesin family
  2. XM_011530959.1XP_011529261.1  moesin isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:40239
    B41; Band 4.1 homologues
    cd13194
    Location:233329
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:124239
    FERM_M; FERM central domain
    pfam00769
    Location:380610
    ERM; Ezrin/radixin/moesin family
    pfam07851
    Location:416497
    TMPIT; TMPIT-like protein
    pfam09379
    Location:42104
    FERM_N; FERM N-terminal domain
  3. XM_017029546.1XP_016885035.1  moesin isoform X3

    Conserved Domains (3) summary
    smart00295
    Location:1195
    B41; Band 4.1 homologues
    cd13194
    Location:189285
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:336566
    ERM; Ezrin/radixin/moesin family
  4. XM_017029545.1XP_016885034.1  moesin isoform X3

    Conserved Domains (3) summary
    smart00295
    Location:1195
    B41; Band 4.1 homologues
    cd13194
    Location:189285
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:336566
    ERM; Ezrin/radixin/moesin family
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