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MSN moesin [ Homo sapiens (human) ]

Gene ID: 4478, updated on 8-Jul-2018
Official Symbol
MSNprovided by HGNC
Official Full Name
moesinprovided by HGNC
Primary source
HGNC:HGNC:7373
See related
Ensembl:ENSG00000147065 MIM:309845; Vega:OTTHUMG00000021723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEL70; IMD50
Summary
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 147.3), appendix (RPKM 142.6) and 24 other tissues See more
Orthologs
See MSN in Genome Data Viewer
Location:
Xq12
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (65588382..65741931)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64808257..64961793)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene LAS1 like, ribosome biogenesis factor Neighboring gene FERM domain containing 8 pseudogene 1 Neighboring gene uncharacterized LOC107985679 Neighboring gene Nanog homeobox pseudogene 9 Neighboring gene eukaryotic translation termination factor 1 pseudogene 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of moesin (MSN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Association and clustering of CD4-CXCR4 induced by HIV-1 gp120 requires moesin-mediated anchoring of actin in the plasma membrane PubMed
env Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation PubMed
env Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with ezrin-radixin-moesin proteins at polarized HIV-1 assembly sites in human T cells PubMed
gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
Vpr vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with moesin (MSN) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
    AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Glial Cell Differentiation, organism-specific biosystem (from WikiPathways)
    Glial Cell Differentiation, organism-specific biosystem
    Glial Cell Differentiation
  • L1CAM interactions, organism-specific biosystem (from REACTOME)
    L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
    Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
    Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Plasma membrane estrogen receptor signaling, organism-specific biosystem
    Plasma membrane estrogen receptor signaling
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
    Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    RhoA signaling pathway, organism-specific biosystem
    RhoA signaling pathway
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell aggregation IDA
Inferred from Direct Assay
more info
PubMed 
T cell migration IDA
Inferred from Direct Assay
more info
PubMed 
T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to testosterone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunological synapse formation IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
leukocyte cell-cell adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
leukocyte migration IEP
Inferred from Expression Pattern
more info
PubMed 
membrane to membrane docking IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of cellular protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of early endosome to late endosome transport IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to early endosome IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lymphocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of organelle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
blood microparticle HDA PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm HDA PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
invadopodium IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 
uropod IEA
Inferred from Electronic Annotation
more info
 
vesicle HDA PubMed 
Preferred Names
moesin
Names
epididymis luminal protein 70
membrane-organizing extension spike protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012516.1 RefSeqGene

    Range
    5001..79283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002444.2NP_002435.1  moesin

    See identical proteins and their annotated locations for NP_002435.1

    Status: REVIEWED

    Source sequence(s)
    BC017293, CN386296, M69066
    Consensus CDS
    CCDS14382.1
    UniProtKB/Swiss-Prot
    P26038
    UniProtKB/TrEMBL
    V9HWC0
    Related
    ENSP00000353408.5, OTTHUMP00000023438, ENST00000360270.6, OTTHUMT00000056981
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:347577
    ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    65588382..65741931
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262269.2XP_005262326.1  moesin isoform X2

    See identical proteins and their annotated locations for XP_005262326.1

    Conserved Domains (6) summary
    smart00295
    Location:8207
    B41; Band 4.1 homologues
    cd13194
    Location:201297
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:92207
    FERM_M; FERM central domain
    pfam00769
    Location:348578
    ERM; Ezrin/radixin/moesin family
    pfam07851
    Location:384465
    TMPIT; TMPIT-like protein
    pfam09379
    Location:1072
    FERM_N; FERM N-terminal domain
  2. XM_011530959.1XP_011529261.1  moesin isoform X1

    Conserved Domains (6) summary
    smart00295
    Location:40239
    B41; Band 4.1 homologues
    cd13194
    Location:233329
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:124239
    FERM_M; FERM central domain
    pfam00769
    Location:380610
    ERM; Ezrin/radixin/moesin family
    pfam07851
    Location:416497
    TMPIT; TMPIT-like protein
    pfam09379
    Location:42104
    FERM_N; FERM N-terminal domain
  3. XM_017029546.1XP_016885035.1  moesin isoform X3

    Conserved Domains (6) summary
    smart00295
    Location:1195
    B41; Band 4.1 homologues
    cd13194
    Location:189285
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:80195
    FERM_M; FERM central domain
    pfam00769
    Location:336566
    ERM; Ezrin/radixin/moesin family
    pfam07851
    Location:372453
    TMPIT; TMPIT-like protein
    pfam09379
    Location:260
    FERM_N; FERM N-terminal domain
  4. XM_017029545.1XP_016885034.1  moesin isoform X3

    Conserved Domains (6) summary
    smart00295
    Location:1195
    B41; Band 4.1 homologues
    cd13194
    Location:189285
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:80195
    FERM_M; FERM central domain
    pfam00769
    Location:336566
    ERM; Ezrin/radixin/moesin family
    pfam07851
    Location:372453
    TMPIT; TMPIT-like protein
    pfam09379
    Location:260
    FERM_N; FERM N-terminal domain
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