Msn moesin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msnprovided by MGI
Official Full Name: moesinprovided by MGI
Primary source: MGI:MGI:97167
See related: Ensembl:ENSMUSG00000031207 AllianceGenome:MGI:97167
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including actin binding activity; double-stranded RNA binding activity; and protein kinase binding activity. Acts upstream of or within positive regulation of podosome assembly. Located in several cellular components, including basolateral plasma membrane; microvillus; and uropod. Is expressed in several structures, including cardiovascular system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 136.0), thymus adult (RPKM 65.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X; X C3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_04	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (95139651..95212159)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (96096045..96168553)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Murine Model of X-Linked Moesin-Associated Immunodeficiency (X-MAID) Reveals Defects in T Cell Homeostasis and Migration.
Title: A Murine Model of X-Linked Moesin-Associated Immunodeficiency (X-MAID) Reveals Defects in T Cell Homeostasis and Migration.
The ERM protein moesin regulates natural killer cell homeostasis in vivo.
Title: The ERM protein moesin regulates natural killer cell homeostasis in vivo.
Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton.
Title: Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton.
This study showed that the Msn exhibited non-significant fold differences in comparison to controls leading to its curial role in development.
Title: Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.
Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP.
Title: The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.
Collectively, these results implicate both moesin and myosin IIA in the regulation of phagolysosome biogenesis and in host defense against infections.
Title: Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages.
these findings underscore the importance of moesin in IL-15-dependent CD8+ Treg cell homeostasis and the control of self-tolerance
Title: The ERM Protein Moesin Regulates CD8(+) Regulatory T Cell Homeostasis and Self-Tolerance.
Moesin is an important regulator of the surface abundance and stability of TbetaRII and is important in facilitating the efficient generation of iTregs.
Title: Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The expression of moesin was upregulated in cardiomyocytes under inflammation, inducing protrusion formation in a phosphorylation-dependent fashion.
Title: Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.
These results of this study may pave the way for exploiting moesin as a novel target for intervention in muscular dystrophy.
Title: Elevated Expression of Moesin in Muscular Dystrophies.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136557 (e-PCR)
- UniSTS:210539

C78546 (e-PCR)
- UniSTS:160889

px-23b2 (e-PCR)
- UniSTS:257428

Psmb7-ps1 (e-PCR), detects polymorphism
- UniSTS:144277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell aggregation	ISO Inferred from Sequence Orthology more info
involved_in T cell migration	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to testosterone stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
involved_in gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in immunological synapse formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of podosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of lymphocyte migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of organelle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell tip	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	ISO Inferred from Sequence Orthology more info
located_in uropod	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: moesin

Names: membrane-organizing extension spike protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010833.2 → NP_034963.2 moesin

See identical proteins and their annotated locations for NP_034963.2

Status: VALIDATED

Source sequence(s)

AL805963, BQ712805, BQ950368, BY336882, CB183208, CB320714, CF584663, M86390

Consensus CDS

CCDS53139.1

UniProtKB/Swiss-Prot

P26041, Q8BSN4

UniProtKB/TrEMBL

A0A8C6HT54

Related

ENSMUSP00000113071.2, ENSMUST00000117399.2

Conserved Domains (6) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:91 → 206

FERM_M; FERM central domain

pfam00769
Location:348 → 577

ERM; Ezrin/radixin/moesin family

pfam07851
Location:383 → 464

TMPIT; TMPIT-like protein

pfam09379
Location:9 → 71

FERM_N; FERM N-terminal domain