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LCP1 lymphocyte cytosolic protein 1 [ Homo sapiens (human) ]

Gene ID: 3936, updated on 15-Apr-2019

Summary

Official Symbol
LCP1provided by HGNC
Official Full Name
lymphocyte cytosolic protein 1provided by HGNC
Primary source
HGNC:HGNC:6528
See related
Ensembl:ENSG00000136167 MIM:153430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN
Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 278.7), bone marrow (RPKM 256.8) and 18 other tissues See more
Orthologs

Genomic context

See LCP1 in Genome Data Viewer
Location:
13q14.13
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (46125923..46182324, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46700058..46756459, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 13 Neighboring gene CPB2 antisense RNA 1 Neighboring gene carboxypeptidase B2 Neighboring gene RNA, 7SL, cytoplasmic 288, pseudogene Neighboring gene uncharacterized LOC105370192 Neighboring gene uncharacterized LOC107984578 Neighboring gene leucine rich repeat containing 63 Neighboring gene RN7SK pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of T-plastin and downregulates the expression of L-plastin in T-cell lines PubMed
Envelope surface glycoprotein gp160, precursor env Plasmin cleaves HIV-1 gp160 precisely at the C-terminal arginine residue 510 of gp120, yielding the mature gp120 and gp41 proteins PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25423, FLJ26114, FLJ39956, DKFZp781A23186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
NOT wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell junction TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
filopodium IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
podosome IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with stress fiber IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
plastin-2
Names
L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)
LCP-1
Lymphocyte cytosolic protein-1 (plasmin)
bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))
epididymis secretory protein Li 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002298.5NP_002289.2  plastin-2

    See identical proteins and their annotated locations for NP_002289.2

    Status: REVIEWED

    Source sequence(s)
    AY960627, BC007673, BF893502, DA820090, DB156931, J02923
    Consensus CDS
    CCDS9403.1
    UniProtKB/Swiss-Prot
    P13796
    UniProtKB/TrEMBL
    A0A024RDT4
    Related
    ENSP00000315757.2, ENST00000323076.7
    Conserved Domains (5) summary
    smart00033
    Location:398501
    CH; Calponin homology domain
    COG5069
    Location:16620
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:121236
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:265370
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    46125923..46182324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266374.2XP_005266431.1  plastin-2 isoform X1

    See identical proteins and their annotated locations for XP_005266431.1

    UniProtKB/Swiss-Prot
    P13796
    UniProtKB/TrEMBL
    A0A024RDT4
    Conserved Domains (5) summary
    smart00033
    Location:398501
    CH; Calponin homology domain
    COG5069
    Location:16620
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00014
    Location:121236
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00307
    Location:265370
    CH; Calponin homology (CH) domain
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