1AOA,1AA2,1QAG,1DXX


Conserved Protein Domain Family
CH

?
cd00014: CH 
Click on image for an interactive view with Cn3D
Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).
Links
?
Statistics
?
PSSM-Id: 237981
View PSSM: cd00014
Aligned: 53 rows
Threshold Bit Score: 59.6319
Threshold Setting Gi: 1825623
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
 
putative actin
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative actin binding surface [polypeptide binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1       ## ###  #  #                                                                    
1AOA         24 EEKYAFVNWINKALEndpdcrhvipmnpntdDLFKAVGDGIVLCKMINLSVPDTIderaink---------------kkl 88
gi 6225157   27 QAEEDLRNWIEEVTGmsi-----------gpNFQLGLKDGIILCELINKLQPGSVkkvne------------------ss 77
gi 2494862    2 EQWRQCGRWLIDCKVlppnhrvv-wpsavvfDLAQALRDGVLLCQLLHNLSPGSIdlkdinf--------------rpqm 66
gi 1723270   65 CSVHEAKKWLEEETNneyq---------nldDFVDALVNGKVLCQLAFKYYPKLAsnwkpr-----------------yq 118
gi 7497065    6 DLWIGCARWLRDMKVlttdk------ngtmlEFASVLRDGILLCRLANTLVPNGIdqkkimr--------------tnqp 65
gi 3023836   28 AMKEDLAEWLNALYGlglp--------gggdGFLTGLATGTTLCQHANAVTEAARalaaarpargva-----fqahsvvp 94
gi 1170586   45 CHLEEAKRWMEACLGedlp---------pttELEEGLRNGVYLAKLGNFFSPKVVslkkiydreq--------trykatg 107
gi 6325014  109 CRVSEVKIWIEAVIEealps-------eielCVGDSLRNGVFLAKLTQRINPDLTtvifpa----------------gdk 165
gi 1841843   25 ESEAEAINWLNQLTNenvp--------fgreNVAAASKNGQISIKLINVVFDGTAslpsaaakmkr------pfkantmt 90
gi 120945    36 PMKEDLALWLTNLLGkei----------taeTFMEKLDNGALLCQLAATVQEKFKesmdankpaktlplkkipckasaps 105
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
Feature 1                   ##  #   # #                ##  ## ##  ##  
1AOA         89 tpfIIQENLNLALNSASa-IGCHVv-nIGAEDLr-aGKPHLVLGLLWQIIKIGL 139
gi 6225157   78 lnwPQLENIGNFIKAIQa-YGMKPhdiFEANDLfenGNMTQVQTTLVALAGLAK 130
gi 2494862   67 sqfLCLKNIRTFLKVCHdkFGLRNselFDPFDLfdvRDFGKVISAVSRLSLHSI 120
gi 1723270  119 iseRNTVYLNAFFHFLDf-IGMFTpfrFETKDLvrrFNIPKVIYCLHALSYLLD 171
gi 7497065   66 spfLCCNNINYFAMFCKtyFNLEDadlFTAEDLyymNGFQKVLKTLSFLSHTKE 119
gi 3023836   95 gsfMARDNVATFIGWCRveLGVPEvlmFETEDLvlrKNEKSVVLCLLEVARRGA 148
gi 1170586  108 lhfRHTDNVIQWLNAMDe-IGLPKifyPETTDI---YDRKNMPRCIYCIHALSL 157
gi 6325014  166 lqfKHTQNINAFFGLVEh-VGVPDsfrFELQDLynkKNIPQVFETLHILISMIN 218
gi 1841843   91 aplNRWKIIQTFLNAAVa-YGVPRaslFQTVDLyelRNMPQVLNTLLQLGTECQ 143
gi 120945   106 gsfFARDNTANFLSWCRd-LGVDEtclFESEGLvlhKQPREVCLCLLELGRIAA 158

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap