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Lcp1 lymphocyte cytosolic protein 1 [ Mus musculus (house mouse) ]

Gene ID: 18826, updated on 3-Apr-2024

Summary

Official Symbol
Lcp1provided by MGI
Official Full Name
lymphocyte cytosolic protein 1provided by MGI
Primary source
MGI:MGI:104808
See related
Ensembl:ENSMUSG00000021998 AllianceGenome:MGI:104808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pls2; pp65; LCP-1; D14Ertd310e
Summary
Enables actin filament binding activity and identical protein binding activity. Acts upstream of or within actin filament bundle assembly. Located in several cellular components, including actin filament; phagocytic cup; and ruffle. Is expressed in several structures, including brain; cardiovascular system; egg cylinder; female reproductive system; and gut. Orthologous to human LCP1 (lymphocyte cytosolic protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 28.5), spleen adult (RPKM 23.6) and 17 other tissues See more
Orthologs
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Genomic context

See Lcp1 in Genome Data Viewer
Location:
14 D3; 14 39.63 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75368570..75468282)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75131105..75230842)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RUN and cysteine rich domain containing beclin 1 interacting protein like Neighboring gene predicted gene, 57618 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75456661-75456962 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75460374-75460674 Neighboring gene STARR-seq mESC enhancer starr_37135 Neighboring gene leucine rich repeat containing 63 Neighboring gene predicted gene 15628 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75576489-75576789 Neighboring gene STARR-seq mESC enhancer starr_37136 Neighboring gene STARR-positive B cell enhancer ABC_E4120 Neighboring gene STARR-positive B cell enhancer ABC_E8899 Neighboring gene STARR-positive B cell enhancer ABC_E7338 Neighboring gene carboxypeptidase B2 Neighboring gene predicted gene, 35679 Neighboring gene STARR-positive B cell enhancer ABC_E7339 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37139 Neighboring gene zinc finger CCCH type containing 13 Neighboring gene predicted gene, 46470

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin filament bundle ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in glial cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podosome ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
plastin-2
Names
65 kDa macrophage protein
L-fimbrin
L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)
plastin 2, L

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001247984.2NP_001234913.1  plastin-2

    See identical proteins and their annotated locations for NP_001234913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC129591, AC161877
    Consensus CDS
    CCDS27276.1
    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
    UniProtKB/TrEMBL
    Q3TJX0, Q3U6Z1, Q3U9M7
    Related
    ENSMUSP00000121201.2, ENSMUST00000124499.8
    Conserved Domains (5) summary
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:98242
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21327
    Location:251375
    CH_PLS2_rpt2; second calponin homology (CH) domain found in plastin-2
    cd21333
    Location:511625
    CH_PLS2_rpt4; fourth calponin homology (CH) domain found in plastin-2
    cl00030
    Location:374507
    CH_SF; calponin homology (CH) domain superfamily
  2. NM_001424512.1NP_001411441.1  plastin-2

    Status: VALIDATED

    Source sequence(s)
    AC129591, AC161877
    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
  3. NM_001424513.1NP_001411442.1  plastin-2

    Status: VALIDATED

    Source sequence(s)
    AC129591, AC161877
    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
  4. NM_001424514.1NP_001411443.1  plastin-2

    Status: VALIDATED

    Source sequence(s)
    AC129591, AC161877
    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
  5. NM_001424515.1NP_001411444.1  plastin-2

    Status: VALIDATED

    Source sequence(s)
    AC129591, AC161877
    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
  6. NM_008879.5NP_032905.2  plastin-2

    See identical proteins and their annotated locations for NP_032905.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC129591, AC161877
    Consensus CDS
    CCDS27276.1
    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
    UniProtKB/TrEMBL
    Q3TJX0, Q3U6Z1, Q3U9M7
    Related
    ENSMUSP00000116271.2, ENSMUST00000145303.8
    Conserved Domains (5) summary
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:98242
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21327
    Location:251375
    CH_PLS2_rpt2; second calponin homology (CH) domain found in plastin-2
    cd21333
    Location:511625
    CH_PLS2_rpt4; fourth calponin homology (CH) domain found in plastin-2
    cl00030
    Location:374507
    CH_SF; calponin homology (CH) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    75368570..75468282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158507.1XP_036014400.1  plastin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UE24, Q61233, Q8R1X3, Q9CV77
    UniProtKB/TrEMBL
    Q3TJX0, Q3U6Z1, Q3U9M7
    Conserved Domains (5) summary
    cd00051
    Location:1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:98242
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21327
    Location:251375
    CH_PLS2_rpt2; second calponin homology (CH) domain found in plastin-2
    cd21333
    Location:511625
    CH_PLS2_rpt4; fourth calponin homology (CH) domain found in plastin-2
    cl00030
    Location:374507
    CH_SF; calponin homology (CH) domain superfamily