1FW4,1CDL,1A2X,1DTL,1TRF,1TCO,1C7V,1BJF,1G8I,1BOD,1JBA,1RTP,1RRO,4CPV,1DGU,5PAL,1JF0,1EJ3


Conserved Protein Domain Family
EFh

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cd00051: EFh 
Click on image for an interactive view with Cn3D
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
Statistics
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PSSM-Id: 238008
View PSSM: cd00051
Aligned: 104 rows
Threshold Bit Score: 42.5349
Threshold Setting Gi: 1431655
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Structure:1FW4_A, each Ca2+ is bound by four sidechains
    View structure with Cn3D
  • Comment:some sites may be non-functional

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1               # # #      #                                # # #      #      
1FW4_A       7 EIREAFRVFDKDGNGYISAAELRHVMtnlg--------ekltDEEVDEMIREADIDGDGQVNYEEFVQMMT 69
gi 584869    1 MAEALFKEIDVNGDGAVSYEEVKAFVskkr--------aiknEQLLQLIFKSIDADGNGEIDQNEFAKFYG 63
gi 115644  153 YTQTILRMFDMNGDGKLGLSEMSRLLpvqenfllkfqgmklsSEEFNAIFAFYDKDGSGFIDEHELDALLK 223
gi 1345664 696 SCRSMIALMDTDGSGKLNLQEFHHLWn--------------kIKAWQKIFKHYDTDQSGTINSYEMRNAVN 752
gi 115902  104 VVKGTWGMCDKNADGQINADEFAAWLtal----------gmsKAEAAEAFNQVDTNGNGELSLDELLTAVR 164
gi 1170824 204 EIEYLISRVDLNDDGRVQFNEFFMHLdg------------vsKDHIKQQFMAIDKDKNGKISPEEMVFGIT 262
gi 115392  145 YTDLMLKLFDSNNDGKLELTEMARLLpvqenfllkfqgvkmcGKEFNKAFELYDQDGDGYIDENELDALLK 215
gi 134734   74 TCRLMVSMLDRDMSGTMGFNEFKELWa--------------vLNGWRQHFISFDSDRSGTVDPQELQKALT 130
gi 1168801   8 DVEDMLRKFDSNGDGNITFDEAVKRLketg--------skdpLRAASSMFISLDKDKDGIISIKEIHGHKA 70
gi 2493462 207 VVLETLEDIDKNGDGFVDQDEYIADMfsheeng---pepdwvLSEREQFNEFRDLNKDGKLDKDEIRHWIL 274

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