Conserved Protein Domain Family
EFh

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cd00051: EFh 
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EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
Statistics
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PSSM-Id: 238008
View PSSM: cd00051
Aligned: 104 rows
Threshold Bit Score: 42.5349
Threshold Setting Gi: 1431655
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Ca2+ binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Structure:1FW4_A, each Ca2+ is bound by four sidechains
    View structure with Cn3D
  • Comment:some sites may be non-functional

cd00051 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00051 is a member of the superfamily cl08302.
cd00051:EFh1JF0 A1EJ3 A1171672128012465419548940586237115644115392134566413473411708241170824116880158486946169954909424934621159021BOD  1198581198591168696729092730481729055465834134565911549511295714424461112959131246891351098134749134756117082511699991FW4 A11539014286110115504231700115501115523117690025062531CDL B996732317001155011155331TRF  5490941153905439367290517290522316807290517290521A2X A1DTL A1C7V A11687511352331729092116878211686961TCO B1154951DGU A1BJF A1G8I A117167058515611716714654181JBA A1169874134637113463721170636462436120165250625413467331355782316801RTP 14CPV  5PAL  1RRO  729056115644729056729056134749135109813475613475913476211708251153911JF0 A1EJ3 A1171672128012465419548940586237115644115392134566413473411708241170824116880158486946169954909424934621159021BOD  1198581198591168696729092730481729055465834134565911549511295714424461112959131246891351098134749134756117082511699991FW4 A11539014286110115504231700115501115523117690025062531CDL B996732317001155011155331TRF  5490941153905439367290517290522316807290517290521A2X A1DTL A1C7V A11687511352331729092116878211686961TCO B1154951DGU A1BJF A1G8I A117167058515611716714654181JBA A1169874134637113463721170636462436120165250625413467331355782316801RTP 14CPV  5PAL  1RRO  72905611564472905672905613474913510981347561347591347621170825115391
cd00051 Sequence Cluster
cd00051 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1               # # #      #                                # # #      #      
1FW4_A       7 EIREAFRVFDKDGNGYISAAELRHVMtnlg--------ekltDEEVDEMIREADIDGDGQVNYEEFVQMMT 69
gi 584869    1 MAEALFKEIDVNGDGAVSYEEVKAFVskkr--------aiknEQLLQLIFKSIDADGNGEIDQNEFAKFYG 63
gi 115644  153 YTQTILRMFDMNGDGKLGLSEMSRLLpvqenfllkfqgmklsSEEFNAIFAFYDKDGSGFIDEHELDALLK 223
gi 1345664 696 SCRSMIALMDTDGSGKLNLQEFHHLWn--------------kIKAWQKIFKHYDTDQSGTINSYEMRNAVN 752
gi 115902  104 VVKGTWGMCDKNADGQINADEFAAWLtal----------gmsKAEAAEAFNQVDTNGNGELSLDELLTAVR 164
gi 1170824 204 EIEYLISRVDLNDDGRVQFNEFFMHLdg------------vsKDHIKQQFMAIDKDKNGKISPEEMVFGIT 262
gi 115392  145 YTDLMLKLFDSNNDGKLELTEMARLLpvqenfllkfqgvkmcGKEFNKAFELYDQDGDGYIDENELDALLK 215
gi 134734   74 TCRLMVSMLDRDMSGTMGFNEFKELWa--------------vLNGWRQHFISFDSDRSGTVDPQELQKALT 130
gi 1168801   8 DVEDMLRKFDSNGDGNITFDEAVKRLketg--------skdpLRAASSMFISLDKDKDGIISIKEIHGHKA 70
gi 2493462 207 VVLETLEDIDKNGDGFVDQDEYIADMfsheeng---pepdwvLSEREQFNEFRDLNKDGKLDKDEIRHWIL 274

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