1FW4,1CDL,1A2X,1DTL,1TRF,1TCO,1C7V,1BJF,1G8I,1BOD,1JBA,1RTP,1RRO,4CPV,1DGU,5PAL,1JF0,1EJ3


Conserved Protein Domain Family
EFh

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cd00051: EFh 
Click on image for an interactive view with Cn3D
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.
Statistics
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PSSM-Id: 238008
View PSSM: cd00051
Aligned: 104 rows
Threshold Bit Score: 42.5349
Threshold Setting Gi: 1431655
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
  • Structure:1FW4_A, each Ca2+ is bound by four sidechains
    View structure with Cn3D
  • Comment:some sites may be non-functional

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # # #      #                                # # #      #      
1FW4_A      7 EIREAFRVFDKDGNGYISAAELRHVMtnlg--------ekltDEEVDEMIREADIDGDGQVNYEEFVQMMT 69  cow
584869      1 MAEALFKEIDVNGDGAVSYEEVKAFVskkr--------aiknEQLLQLIFKSIDADGNGEIDQNEFAKFYG 63  Entamoeba histolytica
115644    153 YTQTILRMFDMNGDGKLGLSEMSRLLpvqenfllkfqgmklsSEEFNAIFAFYDKDGSGFIDEHELDALLK 223 chicken
1345664   696 SCRSMIALMDTDGSGKLNLQEFHHLWn--------------kIKAWQKIFKHYDTDQSGTINSYEMRNAVN 752 human
115902    104 VVKGTWGMCDKNADGQINADEFAAWLtal----------gmsKAEAAEAFNQVDTNGNGELSLDELLTAVR 164 Saccharopolyspora erythraea
1170824   204 EIEYLISRVDLNDDGRVQFNEFFMHLdg------------vsKDHIKQQFMAIDKDKNGKISPEEMVFGIT 262 painted urchin
115392    145 YTDLMLKLFDSNNDGKLELTEMARLLpvqenfllkfqgvkmcGKEFNKAFELYDQDGDGYIDENELDALLK 215 Bos taurus
134734     74 TCRLMVSMLDRDMSGTMGFNEFKELWa--------------vLNGWRQHFISFDSDRSGTVDPQELQKALT 130 long-tailed hamster
1168801     8 DVEDMLRKFDSNGDGNITFDEAVKRLketg--------skdpLRAASSMFISLDKDKDGIISIKEIHGHKA 70  Dictyostelium discoideum
2493462   207 VVLETLEDIDKNGDGFVDQDEYIADMfsheeng---pepdwvLSEREQFNEFRDLNKDGKLDKDEIRHWIL 274 human

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