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KDR kinase insert domain receptor [ Homo sapiens (human) ]

Gene ID: 3791, updated on 18-Jan-2020

Summary

Official Symbol
KDRprovided by HGNC
Official Full Name
kinase insert domain receptorprovided by HGNC
Primary source
HGNC:HGNC:6307
See related
Ensembl:ENSG00000128052 MIM:191306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLK1; CD309; VEGFR; VEGFR2
Summary
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
Expression
Broad expression in placenta (RPKM 44.3), thyroid (RPKM 24.9) and 19 other tissues See more
Orthologs

Genomic context

See KDR in Genome Data Viewer
Location:
4q12
Exon count:
30
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (55078481..55125595, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (55944426..55991762, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 410, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 424, pseudogene Neighboring gene methyltransferase like 5 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 822, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hemangioma, capillary infantile
MedGen: C1865871 OMIM: 602089 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates KDR expression in human mesenchymal stem cells PubMed
Nef nef HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes PubMed
Tat tat Inhibition of sigma receptor or VEGFR causes a significant decrease in HIV-1 Tat- and cocaine-induced H2O2 generation in human pulmonary arterial smooth muscle cells PubMed
tat Downregulation of ZO-1 by treatment with HIV-1 Tat and cocaine is inhibited by VEGFR-2 or sigma receptor antagonists, suggesting that VEGFR-2 and sigma receptor are involved in the downregulation of ZO-1 by Tat and cocaine in pulmonary cells PubMed
tat Microarray analysis indicates HIV-1 Tat-induced downregulation of kinase insert domain receptor (KDR; VEGFR2) in primary human brain microvascular endothelial cells PubMed
tat HIV-1 Tat-induced upregulation of IL17 expression is dependent upon the VEGFR2 signaling pathway in human primary T cells PubMed
tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
tat HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF PubMed
tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
tat The phosphorylation of vascular endothelial growth factor receptor type 2 (Flk-1/KDR) induces the ability of Tat to stimulate focal adhesion assembly and the migration of human brain micro vascular endothelial cells (HBMECs) PubMed
tat Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, greatly arrests Tat-driven KDR phosphorylation and blocks the interaction between Tat and integrin beta1, thus inhibiting the phosphorylation of the kinases FAK, paxillin and MAPKs PubMed
tat Kinase insert domain receptor (a type III receptor tyrosine kinase) 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat VEGFR2 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed
tat HIV-1 Tat, through its basic region (amino acids 49-57), binds and activates VEGFR-2, an effect associated with Tat-mediated pathogenesis and induction of angiogenesis in AIDS-associated Kaposi's sarcoma PubMed
tat The interaction of HIV-1 Tat with KDR/VEGFR2 is implicated in the activation of ERK1 and ERK2 signaling pathways PubMed
tat The activation of AKT and the protection of Kaposi's sarcoma cells from apoptosis mediated by HIV-1 Tat involves the interaction of Tat with VEGFR2 PubMed
nucleocapsid gag KDR is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding TAS
Traceable Author Statement
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
calcium-mediated signaling using intracellular calcium source IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration involved in sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hydrogen sulfide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mitochondrial depolarization IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mitochondrial fission IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sorting endosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
vascular endothelial growth factor receptor 2
Names
fetal liver kinase-1
kinase insert domain receptor (a type III receptor tyrosine kinase)
protein-tyrosine kinase receptor Flk-1
soluble VEGFR2
tyrosine kinase growth factor receptor
NP_002244.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012004.1 RefSeqGene

    Range
    5001..52115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002253.3NP_002244.1  vascular endothelial growth factor receptor 2 precursor

    See identical proteins and their annotated locations for NP_002244.1

    Status: REVIEWED

    Source sequence(s)
    AC111194, AF035121, BM978033, BP280621
    Consensus CDS
    CCDS3497.1
    UniProtKB/Swiss-Prot
    P35968
    UniProtKB/TrEMBL
    A0A024RD88
    Related
    ENSP00000263923.4, ENST00000263923.5
    Conserved Domains (10) summary
    cd05862
    Location:239326
    Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
    cd05864
    Location:348417
    Ig2_VEGFR-2; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)
    smart00408
    Location:680744
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:565661
    IG; Immunoglobulin
    smart00410
    Location:231324
    IG_like; Immunoglobulin like
    pfam07679
    Location:667754
    I-set; Immunoglobulin I-set domain
    cd05103
    Location:8261167
    PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
    pfam07714
    Location:8341160
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:551661
    Ig_2; Immunoglobulin domain
    cl11960
    Location:41109
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    55078481..55125595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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