Conserved Protein Domain Family
Ig_VEGFR-2

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cd05864: Ig_VEGFR-2 (this model, PSSM-Id:143272 is obsolete and has been replaced by 409450)
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)
Ig_VEGF-2: immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. VEGFRs bind VEGFs with high affinity at the Ig-like domains. VEGFR-2 (KDR/Flk-1) is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A; VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGF-A also interacts with VEGFR-1, which it binds more strongly than VEGFR-2. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells.
Statistics
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PSSM-Id: 143272
Aligned: 3 rows
Threshold Bit Score: 129.665
Threshold Setting Gi: 209743752
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P52583   339 VSIPVKFkGYPPPEAKWYKNGKvinan----htvklGYALVItEATEKDAGNYTVVLTNPTNKmqKRHTFTLLV 408  Japanese quail
9087218  348 VRIPAKYlGYPPPEIKWYKNGIplesn----htikaGHVLTImEVSERDTGNYTVILTNPISKekQSHVVSLVV 417  human
Q5GIT4   356 AKILVKYyAYPEPAVRWYKNDQlivlrdeyrmkfyrGVHLTIyGVTEKDAGNYTVVMTNKITKeeQRRTFQLVV 429  zebrafish
9087218  348 VRIPAKYlGYPPPEIKWYKNGIplesn----htikaGHVLTImEVSERDTGNYTVILTNPISKekQSHVVSLVV 417  human
Q5GIT4   356 AKILVKYyAYPEPAVRWYKNDQlivlrdeyrmkfyrGVHLTIyGVTEKDAGNYTVVMTNKITKeeQRRTFQLVV 429  zebrafish
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