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Kdr kinase insert domain protein receptor [ Mus musculus (house mouse) ]

Gene ID: 16542, updated on 5-Jan-2023

Summary

Official Symbol
Kdrprovided by MGI
Official Full Name
kinase insert domain protein receptorprovided by MGI
Primary source
MGI:MGI:96683
See related
Ensembl:ENSMUSG00000062960 AllianceGenome:MGI:96683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
orv; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07
Summary
Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including circulatory system development; peptidyl-tyrosine autophosphorylation; and positive regulation of vasculogenesis. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Located in several cellular components, including cell junction; endosome; and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including adhesions of uterus; artery disease (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 42.4), heart adult (RPKM 19.3) and 22 other tissues See more
Orthologs
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Genomic context

See Kdr in Genome Data Viewer
Location:
5 C3.3; 5 40.23 cM
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76093487..76139885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75932827..75979072, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32558 Neighboring gene predicted gene, 54290 Neighboring gene predicted gene, 32727 Neighboring gene predicted gene, 32780 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 5_758.1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within blood vessel endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel endothelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen sulfide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endochondral bone growth ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymph vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor-2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sorting endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vascular endothelial growth factor receptor 2
Names
VEGF receptor-2
fetal liver kinase 1
kinase NYK
protein-tyrosine kinase receptor flk-1
soluble vascular endothelial growth factor receptor 2
vascular endothelial growth factor receptor-3
NP_001350145.1
NP_034742.2
XP_011239119.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363216.1NP_001350145.1  vascular endothelial growth factor receptor 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    EU884114
    Related
    ENSMUST00000202473.4
    Conserved Domains (2) summary
    pfam13927
    Location:549642
    Ig_3; Immunoglobulin domain
    cl11960
    Location:241327
    Ig; Immunoglobulin domain
  2. NM_001403141.1NP_001390070.1  vascular endothelial growth factor receptor 2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723
    UniProtKB/Swiss-Prot
    Q8VCD0
  3. NM_001403142.1NP_001390071.1  vascular endothelial growth factor receptor 2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723
  4. NM_001403143.1NP_001390072.1  vascular endothelial growth factor receptor 2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723
  5. NM_001403144.1NP_001390073.1  vascular endothelial growth factor receptor 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723
  6. NM_010612.3NP_034742.2  vascular endothelial growth factor receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034742.2

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723
    Consensus CDS
    CCDS39114.1
    UniProtKB/Swiss-Prot
    Q8VCD0
    UniProtKB/TrEMBL
    Q8VCD0
    Related
    ENSMUSP00000109144.2, ENSMUST00000113516.2
    Conserved Domains (6) summary
    cd05103
    Location:8241165
    PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
    pfam17988
    Location:757791
    VEGFR-2_TMD; VEGFR-2 Transmembrane domain
    pfam07679
    Location:665742
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:549643
    Ig_3; Immunoglobulin domain
    cd00096
    Location:331334
    Ig; Ig strand A [structural motif]
    cl11960
    Location:331419
    Ig; Immunoglobulin domain

RNA

  1. NR_175357.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723
  2. NR_175358.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC124615, AC134903, AC160723

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    76093487..76139885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240817.4XP_011239119.1  vascular endothelial growth factor receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05103
    Location:632973
    PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
    pfam07679
    Location:473550
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:357451
    Ig_3; Immunoglobulin domain
    pfam17988
    Location:565599
    VEGFR-2_TMD; VEGFR-2 Transmembrane domain
    cl11960
    Location:49135
    Ig; Immunoglobulin domain