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KCNG1 potassium voltage-gated channel modifier subfamily G member 1 [ Homo sapiens (human) ]

Gene ID: 3755, updated on 1-Jun-2020

Summary

Official Symbol
KCNG1provided by HGNC
Official Full Name
potassium voltage-gated channel modifier subfamily G member 1provided by HGNC
Primary source
HGNC:HGNC:6248
See related
Ensembl:ENSG00000026559 MIM:603788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K13; kH2; KCNG; KV6.1
Summary
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]
Expression
Biased expression in endometrium (RPKM 3.9), placenta (RPKM 2.0) and 11 other tissues See more
Orthologs

Genomic context

See KCNG1 in Genome Data Viewer
Location:
20q13.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (51003656..51023176, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49620193..49639675, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene Sharpr-MPRA regulatory region 8647 Neighboring gene uncharacterized LOC105372662 Neighboring gene uncharacterized LOC105372661 Neighboring gene ribosomal protein SA pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of KCNG1 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
Knockdown of potassium voltage-gated channel, subfamily G, member 1 (KCNG1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium channel activity NAS
Non-traceable Author Statement
more info
PubMed 
voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
potassium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
regulation of delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily G member 1
Names
potassium channel KH2
potassium channel Kv6.1
potassium channel, voltage gated modifier subfamily G, member 1
potassium voltage-gated channel, subfamily G, member 1
voltage-gated potassium channel subunit Kv6.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002237.4NP_002228.2  potassium voltage-gated channel subfamily G member 1

    See identical proteins and their annotated locations for NP_002228.2

    Status: REVIEWED

    Source sequence(s)
    AF033383, BC046629, BG029104, CN301212, CN480356, DA684016
    Consensus CDS
    CCDS13436.1
    UniProtKB/Swiss-Prot
    Q9UIX4
    UniProtKB/TrEMBL
    Q86Y85
    Related
    ENSP00000360626.4, ENST00000371571.5
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    51003656..51023176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528804.1XP_011527106.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527106.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  2. XM_011528800.2XP_011527102.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527102.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  3. XM_011528802.2XP_011527104.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527104.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  4. XM_011528806.2XP_011527108.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527108.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  5. XM_006723785.3XP_006723848.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_006723848.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  6. XM_011528801.2XP_011527103.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527103.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  7. XM_011528803.2XP_011527105.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527105.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain
  8. XM_011528805.2XP_011527107.1  potassium voltage-gated channel subfamily G member 1 isoform X1

    See identical proteins and their annotated locations for XP_011527107.1

    UniProtKB/Swiss-Prot
    Q9UIX4
    Conserved Domains (2) summary
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
    pfam02214
    Location:65164
    BTB_2; BTB/POZ domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172318.2: Suppressed sequence

    Description
    NM_172318.2: This RefSeq was temporarily suppressed because its source, BC006367.1, was from a cancerous cell line. The remaining transcript data that support this splice variant are of incomplete length.
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