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Kcng1 potassium voltage-gated channel, subfamily G, member 1 [ Mus musculus (house mouse) ]

Gene ID: 241794, updated on 18-Sep-2024

Summary

Official Symbol
Kcng1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily G, member 1provided by MGI
Primary source
MGI:MGI:3616086
See related
Ensembl:ENSMUSG00000074575 AllianceGenome:MGI:3616086
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predicted to act upstream of or within regulation of ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Orthologous to human KCNG1 (potassium voltage-gated channel modifier subfamily G member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 3.0), testis adult (RPKM 2.6) and 21 other tissues See more
Orthologs
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Genomic context

See Kcng1 in Genome Data Viewer
Location:
2 H3; 2 88.55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168102037..168123453, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168260117..168281533, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06458 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene STARR-positive B cell enhancer mm9_chr2:168075791-168076092 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene Neighboring gene predicted gene, 33262 Neighboring gene predicted gene, 22704 Neighboring gene predicted gene, 39992

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily G member 1
Names
orthologue of H. sapiens potassium voltage-gated channel, subfamily G, member 1 (KCNG1)
voltage-gated potassium channel subunit Kv6.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081134.2NP_001074603.1  potassium voltage-gated channel subfamily G member 1

    See identical proteins and their annotated locations for NP_001074603.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BX005039
    Consensus CDS
    CCDS38344.1
    UniProtKB/Swiss-Prot
    A2BDX4
    UniProtKB/TrEMBL
    B2RVK9
    Related
    ENSMUSP00000104815.2, ENSMUST00000109191.2
    Conserved Domains (2) summary
    cd18421
    Location:60173
    BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein
  2. NM_001379458.1NP_001366387.1  potassium voltage-gated channel subfamily G member 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BX005039
    UniProtKB/Swiss-Prot
    A2BDX4
    UniProtKB/TrEMBL
    B2RVK9
    Related
    ENSMUSP00000096668.3, ENSMUST00000099069.3
    Conserved Domains (2) summary
    cd18421
    Location:60173
    BTB_POZ_KCNG1_2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2
    pfam00520
    Location:227471
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168102037..168123453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)