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ZNF850 zinc finger protein 850 [ Homo sapiens (human) ]

Gene ID: 342892, updated on 6-Sep-2022

Summary

Official Symbol
ZNF850provided by HGNC
Official Full Name
zinc finger protein 850provided by HGNC
Primary source
HGNC:HGNC:27994
See related
Ensembl:ENSG00000267041 AllianceGenome:HGNC:27994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF850P
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 1.4), placenta (RPKM 0.7) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF850 in Genome Data Viewer
Location:
19q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36743480..36772807, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39418764..39448090, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37234382..37263709, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 461 Neighboring gene zinc finger protein 567 Neighboring gene ZNF567 divergent transcript Neighboring gene uncharacterized LOC728485 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene zinc finger protein 790

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 850
Names
putative zinc finger protein ENSP00000330994

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193552.2NP_001180481.1  zinc finger protein 850 isoform 1

    See identical proteins and their annotated locations for NP_001180481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020928, AC074138, BC052603
    Consensus CDS
    CCDS59379.1
    UniProtKB/Swiss-Prot
    A8MQ14
    Related
    ENSP00000464976.1, ENST00000591344.2
    Conserved Domains (5) summary
    smart00349
    Location:767
    KRAB; krueppel associated box
    COG5048
    Location:531947
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:899919
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:687711
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001267779.2NP_001254708.1  zinc finger protein 850 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC020928, AC074138, AW440392, BC052603, BC143637
    Consensus CDS
    CCDS74350.1
    UniProtKB/TrEMBL
    A0A087X0M6
    Related
    ENSP00000483509.1, ENST00000614887.4
    Conserved Domains (5) summary
    smart00349
    Location:750
    KRAB; krueppel associated box
    COG5048
    Location:499915
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:867887
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:746
    KRAB; KRAB box
    pfam13465
    Location:655679
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36743480..36772807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39418764..39448090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_008207.3: Suppressed sequence

    Description
    NG_008207.3: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.