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LRIT2 leucine rich repeat, Ig-like and transmembrane domains 2 [ Homo sapiens (human) ]

Gene ID: 340745, updated on 25-Jan-2022

Summary

Official Symbol
LRIT2provided by HGNC
Official Full Name
leucine rich repeat, Ig-like and transmembrane domains 2provided by HGNC
Primary source
HGNC:HGNC:23443
See related
Ensembl:ENSG00000204033 AllianceGenome:HGNC:23443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC22
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in skin (RPKM 1.2), brain (RPKM 0.4) and 1 other tissue See more
Orthologs
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Genomic context

See LRIT2 in Genome Data Viewer
Location:
10q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (84220485..84225589, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (85980241..85985345, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 99 Neighboring gene cadherin related family member 1 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 1 Neighboring gene retinal G protein coupled receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2
Names
leucine rich repeat containing 22
leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
leucine-rich repeat-containing protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017924.5NP_001017924.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001017924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC140765, BX648524
    Consensus CDS
    CCDS31234.1
    UniProtKB/Swiss-Prot
    A6NDA9
    Related
    ENSP00000361185.3, ENST00000372113.7
    Conserved Domains (9) summary
    smart00408
    Location:267334
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:367430
    FN3; Fibronectin type 3 domain
    cd00116
    Location:75164
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:253344
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:5880
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3755
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:81119
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:103163
    LRR_8; Leucine rich repeat
    cl15307
    Location:200243
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. NM_001284223.1NP_001271152.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001271152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022389, BC140765, BX648524
    Consensus CDS
    CCDS60581.1
    UniProtKB/Swiss-Prot
    A6NDA9
    Related
    ENSP00000438264.1, ENST00000538192.5
    Conserved Domains (9) summary
    smart00408
    Location:267344
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:377440
    FN3; Fibronectin type 3 domain
    cd00116
    Location:75164
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:253354
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:5880
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:3755
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:81119
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:103163
    LRR_8; Leucine rich repeat
    cl15307
    Location:200243
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    84220485..84225589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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