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HSPE1 heat shock protein family E (Hsp10) member 1 [ Homo sapiens (human) ]

Gene ID: 3336, updated on 5-Aug-2018

Summary

Official Symbol
HSPE1provided by HGNC
Official Full Name
heat shock protein family E (Hsp10) member 1provided by HGNC
Primary source
HGNC:HGNC:5269
See related
Ensembl:ENSG00000115541 MIM:600141; Vega:OTTHUMG00000132749
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPF; CPN10; GROES; HSP10
Summary
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in adrenal (RPKM 184.7), kidney (RPKM 90.5) and 24 other tissues See more
Orthologs

Genomic context

See HSPE1 in Genome Data Viewer
Location:
2q33.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (197499997..197503463)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198364721..198368187)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene coenzyme Q10B Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene MOB family member 4, phocein Neighboring gene RNA, Ro-associated Y5 pseudogene 2 Neighboring gene raftlin family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of heat shock 10kDa protein 1 (HSPE1; HSP10) in Jurkat cells PubMed
integrase gag-pol HSP10 interacts with HIV-1 integrase, which is a substrate for the hHSP60-HSP10 complex PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
membrane HDA PubMed 
mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
10 kDa heat shock protein, mitochondrial
Names
10 kDa chaperonin
chaperonin 10
early-pregnancy factor
heat shock 10kD protein 1 (chaperonin 10)
heat shock 10kDa protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008914.1 RefSeqGene

    Range
    5001..8467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002157.2NP_002148.1  10 kDa heat shock protein, mitochondrial

    See identical proteins and their annotated locations for NP_002148.1

    Status: REVIEWED

    Source sequence(s)
    BC023518, BG188453, CN264788
    Consensus CDS
    CCDS2320.1
    UniProtKB/Swiss-Prot
    P61604
    Related
    ENSP00000233893.5, OTTHUMP00000163630, ENST00000233893.9, OTTHUMT00000256112
    Conserved Domains (1) summary
    cd00320
    Location:8100
    cpn10; Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    197499997..197503463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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