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Hspe1 heat shock protein 1 (chaperonin 10) [ Mus musculus (house mouse) ]

Gene ID: 15528, updated on 8-Jan-2023

Summary

Official Symbol
Hspe1provided by MGI
Official Full Name
heat shock protein 1 (chaperonin 10)provided by MGI
Primary source
MGI:MGI:104680
See related
Ensembl:ENSMUSG00000073676 AllianceGenome:MGI:104680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
10kDa; Hsp10; mt-cpn10
Summary
Predicted to enable chaperone binding activity; metal ion binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in mitochondrion. Is expressed in early conceptus. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 162.7), placenta adult (RPKM 143.3) and 21 other tissues See more
Orthologs
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Genomic context

See Hspe1 in Genome Data Viewer
Location:
1; 1 C1.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55127307..55130476)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55088148..55091317)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 1 Neighboring gene coenzyme Q10B Neighboring gene ribosomal protein S2 pseudogene Neighboring gene heat shock protein 1 (chaperonin) Neighboring gene ribosomal protein L7A pseudogene Neighboring gene serine/arginine repetitive matrix 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117526

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
10 kDa heat shock protein, mitochondrial
Names
10 kDa chaperonin
CPN10
chaperonin 10
heat shock 10 kDa protein 1 (chaperonin 10)
mitochondrial chaperonin 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008303.4NP_032329.1  10 kDa heat shock protein, mitochondrial

    See identical proteins and their annotated locations for NP_032329.1

    Status: VALIDATED

    Source sequence(s)
    AV570511, BC099385, CJ238411
    Consensus CDS
    CCDS35570.1
    UniProtKB/Swiss-Prot
    Q64433
    UniProtKB/TrEMBL
    Q4KL76
    Related
    ENSMUSP00000074724.7, ENSMUST00000075242.7
    Conserved Domains (1) summary
    cd00320
    Location:8100
    cpn10; Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    55127307..55130476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)