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MOB4 MOB family member 4, phocein [ Homo sapiens (human) ]

Gene ID: 25843, updated on 2-May-2024

Summary

Official Symbol
MOB4provided by HGNC
Official Full Name
MOB family member 4, phoceinprovided by HGNC
Primary source
HGNC:HGNC:17261
See related
Ensembl:ENSG00000115540 MIM:609361; AllianceGenome:HGNC:17261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3
Summary
This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues See more
Orthologs
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Genomic context

Location:
2q33.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (197515554..197553699)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197999154..198037300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198380278..198418423)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16939 Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12215 Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene uncharacterized LOC124907952 Neighboring gene RNY5 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:198447337-198447852 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198451577-198452275 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198452276-198452973 Neighboring gene raftlin family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16940 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198484019-198484523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:198484980-198485480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198532470-198533059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198533060-198533648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16943 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC12264

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MOB-like protein phocein
Names
MOB1, Mps One Binder kinase activator-like 3
Mps One Binder kinase activator-like 3
class II mMOB1
mob1 homolog 3
phocein, Mob-like protein
preimplantation protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100819.3NP_001094289.1  MOB-like protein phocein isoform 3

    See identical proteins and their annotated locations for NP_001094289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC020550, AK297514, BC005237, CR736874
    Consensus CDS
    CCDS46480.1
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000405354.2, ENST00000448447.6
    Conserved Domains (1) summary
    pfam03637
    Location:32186
    Mob1_phocein; Mob1/phocein family
  2. NM_001204094.1NP_001191023.1  MOB-like protein phocein isoform 2

    See identical proteins and their annotated locations for NP_001191023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC020550, AK292938, CR736874, DC375649
    Consensus CDS
    CCDS2322.1
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000387289.1, ENST00000409360.1
    Conserved Domains (1) summary
    pfam03637
    Location:21175
    Mob1_phocein; Mob1/phocein family
  3. NM_015387.5NP_056202.2  MOB-like protein phocein isoform 1

    See identical proteins and their annotated locations for NP_056202.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC020550, BC005237, CR736874
    Consensus CDS
    CCDS2321.1
    UniProtKB/Swiss-Prot
    B4DML0, Q53SE0, Q7Z4Y6, Q9H2P3, Q9H5J1, Q9Y3A3, Q9Y4T8
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000315702.4, ENST00000323303.9
    Conserved Domains (1) summary
    pfam03637
    Location:53207
    Mob1_phocein; Mob1/phocein family
  4. NM_199482.4NP_955776.1  MOB-like protein phocein isoform 2

    See identical proteins and their annotated locations for NP_955776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
    Source sequence(s)
    AC020550, AF250319, AL080070, CR736874, DC298610
    Consensus CDS
    CCDS2322.1
    UniProtKB/TrEMBL
    A8K012
    Related
    ENSP00000233892.4, ENST00000233892.8
    Conserved Domains (1) summary
    pfam03637
    Location:21175
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    197515554..197553699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    197999154..198037300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)