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ZBTB44 zinc finger and BTB domain containing 44 [ Homo sapiens (human) ]

Gene ID: 29068, updated on 1-Jun-2020

Summary

Official Symbol
ZBTB44provided by HGNC
Official Full Name
zinc finger and BTB domain containing 44provided by HGNC
Primary source
HGNC:HGNC:25001
See related
Ensembl:ENSG00000196323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTBD15; ZNF851; HSPC063
Expression
Ubiquitous expression in testis (RPKM 15.0), kidney (RPKM 11.4) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB44 in Genome Data Viewer
Location:
11q24.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (130226677..130314917, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (130096572..130184663, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 pseudogene 21 Neighboring gene amyloid beta precursor like protein 2 Neighboring gene ST14 transmembrane serine protease matriptase Neighboring gene NDUFAF2 pseudogene 2 Neighboring gene DEAD-box helicase 18 pseudogene 5 Neighboring gene RNA, 7SL, cytoplasmic 778, pseudogene Neighboring gene ZBTB44 divergent transcript Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26123, MGC57431, MGC60348, MGC88058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 44
Names
BTB (POZ) domain containing 15
BTB/POZ domain-containing protein 15
zinc finger protein 851

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301098.2NP_001288027.1  zinc finger and BTB domain-containing protein 44 isoform 1

    See identical proteins and their annotated locations for NP_001288027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC019227, AP001183, AP002986, BC030580, BC049375
    Consensus CDS
    CCDS73414.1
    UniProtKB/Swiss-Prot
    Q8NCP5
    UniProtKB/TrEMBL
    H7BY22
    Related
    ENSP00000350574.4, ENST00000357899.9
    Conserved Domains (5) summary
    COG5048
    Location:383449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:489511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21128
    BTB; BTB/POZ domain
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001301099.1NP_001288028.1  zinc finger and BTB domain-containing protein 44 isoform 2

    See identical proteins and their annotated locations for NP_001288028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 8 both encode the same isoform (2).
    Source sequence(s)
    AC019227, AP001183, BC030580, BC049375, BC050723
    Consensus CDS
    CCDS73415.1
    UniProtKB/Swiss-Prot
    Q8NCP5
    Related
    ENSP00000434177.1, ENST00000530205.5
    Conserved Domains (4) summary
    COG5048
    Location:383449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
    cd18228
    Location:15130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
  3. NM_001370219.1NP_001357148.1  zinc finger and BTB domain-containing protein 44 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
    Source sequence(s)
    AC019227, AP001183, AP002986
    Related
    ENSP00000436187.2, ENST00000527478.6
    Conserved Domains (6) summary
    COG5048
    Location:383449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:489511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:487508
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
    cd18228
    Location:15130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
  4. NM_001370220.1NP_001357149.1  zinc finger and BTB domain-containing protein 44 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC019227, AP001183, AP002986
    Conserved Domains (6) summary
    COG5048
    Location:350431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:471493
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:469490
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:395420
    zf-H2C2_2; Zinc-finger double domain
    cd18228
    Location:15130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
  5. NM_001370221.1NP_001357150.1  zinc finger and BTB domain-containing protein 44 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC019227, AP001183, AP002986
    Conserved Domains (4) summary
    COG5048
    Location:350431
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:395420
    zf-H2C2_2; Zinc-finger double domain
    cd18228
    Location:15130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
  6. NM_001370222.1NP_001357151.1  zinc finger and BTB domain-containing protein 44 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC019227, AP001183, AP002986
    Conserved Domains (2) summary
    sd00017
    Location:1232
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  7. NM_001370223.1NP_001357152.1  zinc finger and BTB domain-containing protein 44 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC019227, AK024659, AP001183, AP002986
    Conserved Domains (4) summary
    COG5048
    Location:383449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
    cd18228
    Location:15130
    BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
  8. NM_014155.4NP_054874.3  zinc finger and BTB domain-containing protein 44 isoform 3

    See identical proteins and their annotated locations for NP_054874.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) retains two alternate introns and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC019227, AI446067, AP001183, BC071729, CD671410
    Consensus CDS
    CCDS44776.1
    UniProtKB/Swiss-Prot
    Q8NCP5
    Related
    ENSP00000433457.1, ENST00000525842.5
    Conserved Domains (4) summary
    COG5048
    Location:383449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21128
    BTB; BTB/POZ domain
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_163264.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC019227, AP001183, AP002986, BC049375
    Related
    ENST00000445008.6
  2. NR_163265.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC019227, AP001183, AP002986

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    130226677..130314917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718826.4XP_006718889.1  zinc finger and BTB domain-containing protein 44 isoform X6

    Conserved Domains (6) summary
    smart00225
    Location:32128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:351432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:382404
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:396421
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006718825.4XP_006718888.1  zinc finger and BTB domain-containing protein 44 isoform X2

    See identical proteins and their annotated locations for XP_006718888.1

    Conserved Domains (7) summary
    smart00225
    Location:32128
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:351432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:384404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:472494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:382404
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:396421
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024448456.1XP_024304224.1  zinc finger and BTB domain-containing protein 44 isoform X4

    Conserved Domains (5) summary
    COG5048
    Location:383449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:489511
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21128
    BTB; BTB/POZ domain
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_246423.5 RNA Sequence

  2. XR_002957142.1 RNA Sequence

  3. XR_246421.5 RNA Sequence

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