1BBO,4IS1


Conserved Protein Domain Family
ZF_C2H2
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sd00020: ZF_C2H2 
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Zinc finger, C2H2 type
The C2H2 zinc finger is a classical zinc finger domain. C2H2-type zinc fingers are ubiquitous; more than 1% of all mammalian proteins are predicted to contain at least one zinc finger. They often function as DNA or protein binding structural motifs, such as in eukaryotic transcription factors, and therefore they play important roles in cellular processes such as development, differentiation, and oncosuppression. C2H2 zinc finger proteins contain from 1 to more than 30 zinc finger repeats.
Links
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Statistics
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PSSM-Id: 275371
Aligned: 226 rows
Threshold Bit Score: 25.8069
Created: 21-Feb-2014
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:1BBO_A, Human Enhancer Binding Protein Mbp-1 zinc finger contacts to Zn ion.
  • Comment:The small C2H2 zinc finger domain is conformationally stabilized by coordinating a zinc ion on the two invariant cysteine and histidine residues.
  • Citation:PMID 2028256
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #            #      #                                                        
1BBO_A          4 CEECGIRXKKPSMLKKHI---RTHtdvr---------------------------------------------------- 28   human
CBH11659      261 CELCNRTFNSEIDLLQHLe--TRHpdgtaegpagvdsaaiadvaqfsakeattggdqrvhvicdlcvssskvykmpsalf 338 
CCC48318      236 CELCGRTFQSEPDLLQHLe--TRHpdgtvgkhggvensaaaevaefaareatagggqrvqvvcdlcpssskvytmpsalf 313 
CCC90893      232 CELCNRMFNSENDLLNHLe--TRHpdgtmdgpsavdaaaiadvaqftareatagvdqrvhvvcdlctssskvynmpsalf 309 
NP_001123333  514 CDVCDMWFRHPRQLVQHVk-tPDHksnvsqtfgdedisnnssenilpdeqsdkdhmqhgk--------------qykgne 578 
EFZ14285      522 CSVCNLIFRKPSLLNLHM---TIHssndiki------------------------------------------------- 549 
EGE86389        3 CIPCNRRFKNETALEKHIkysPAHalk----------------------------------------------------- 29  
CBX94071      108 CGVCSIKFPTKSALITHTk-qLPHhq------------------------------------------------------ 132 
EHA28168       17 CSICDRYFRTDGALFAHCratTRHe------------------------------------------------------- 41  
XP_003307146    6 CEPCGRHFRLYQHYEDHLihsPRHh------------------------------------------------------- 30  

Feature 1                                                               
1BBO_A         29 ---------------------------pyhCTYCNFSFKTKGNLTKHMk-sKAH 54   human
CBH11659      339 shirfkhpnedaafhverlireqktvssfvCTVCQKAFASAAALDGHFn--SKH 390 
CCC48318      314 shirfkhpgedaafhverlirqqktttsfvCKVCNKAFATESALEGHFs--SKH 365 
CCC90893      310 shirfkhpsedaafhverllraqksapsfvCKVCQKVFASAAALDGHFs--SKH 361 
NP_001123333  579 eiqnkkkvdivpegefkldiphiipvtgyyCDACCDFFFDEGSTLNHCk-sDSH 631 
EFZ14285      550 ------------------------enqisaCPQCGLEFQKPSELVNHV---SQH 576 
EGE86389       30 ----------------------------ydCSSCSRSFSSQNALGQHIr--DSH 53  
CBX94071      133 ----------------------------hyCNLCRRVFKDRNGLKNHVdnsWGH 158 
EHA28168       42 -----------------------------wCERCRRVFISEASKNAHIqasNKH 66  
XP_003307146   31 -----------------------------yCEPCQRDFTSQNAKENHLrhsEQH 55

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