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ZNF789 zinc finger protein 789 [ Homo sapiens (human) ]

Gene ID: 285989, updated on 23-Nov-2021

Summary

Official Symbol
ZNF789provided by HGNC
Official Full Name
zinc finger protein 789provided by HGNC
Primary source
HGNC:HGNC:27801
See related
Ensembl:ENSG00000198556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 3.7), testis (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF789 in Genome Data Viewer
Location:
7q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99472819..99487605)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99070513..99085228)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene ATP synthase membrane subunit f Neighboring gene tRNA-Trp (anticodon CCA) 5-1 Neighboring gene zinc finger protein 394 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene zinc finger protein 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013258.2NP_001013276.1  zinc finger protein 789 isoform 2

    See identical proteins and their annotated locations for NP_001013276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' exons, but has an alternate 3' exon, as compared to variant 1. The encoded isoform 2 has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC073063, AK093141, BC031249, BM840763
    Consensus CDS
    CCDS34694.1
    UniProtKB/Swiss-Prot
    Q5FWF6
    Related
    ENSP00000369047.3, ENST00000379724.3
    Conserved Domains (1) summary
    pfam01352
    Location:1050
    KRAB; KRAB box
  2. NM_001350999.2NP_001337928.1  zinc finger protein 789 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073063
    Conserved Domains (3) summary
    smart00349
    Location:154
    KRAB; krueppel associated box
    COG5048
    Location:236296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242262
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001351000.2NP_001337929.1  zinc finger protein 789 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073063
    Conserved Domains (3) summary
    COG5048
    Location:215275
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:221241
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1051
    KRAB; KRAB box
  4. NM_001351001.2NP_001337930.1  zinc finger protein 789 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073063
    Conserved Domains (1) summary
    pfam01352
    Location:1051
    KRAB; KRAB box
  5. NM_001351002.2NP_001337931.1  zinc finger protein 789 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 6.
    Source sequence(s)
    AC073063
    Conserved Domains (2) summary
    COG5048
    Location:158218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164184
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001351004.2NP_001337933.1  zinc finger protein 789 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 6.
    Source sequence(s)
    AC073063, AK309467
    Conserved Domains (2) summary
    COG5048
    Location:158218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164184
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_213603.3NP_998768.2  zinc finger protein 789 isoform 1

    See identical proteins and their annotated locations for NP_998768.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC073063, AK093141, BC089424, BI767175
    Consensus CDS
    CCDS34693.1
    UniProtKB/Swiss-Prot
    Q5FWF6
    Related
    ENSP00000331927.5, ENST00000331410.10
    Conserved Domains (5) summary
    smart00349
    Location:1171
    KRAB; krueppel associated box
    COG5048
    Location:283420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1150
    KRAB; KRAB box
    pfam13465
    Location:271296
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_147001.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073063
  2. NR_147002.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073063, BC031249, CB140921
  3. NR_147003.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073063, AK309467, BC031249
    Related
    ENST00000483089.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99472819..99487605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516067.2XP_011514369.1  zinc finger protein 789 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:276413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252272
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017012018.1XP_016867507.1  zinc finger protein 789 isoform X1

    UniProtKB/Swiss-Prot
    Q5FWF6
    Conserved Domains (5) summary
    smart00349
    Location:1171
    KRAB; krueppel associated box
    COG5048
    Location:283420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1150
    KRAB; KRAB box
    pfam13465
    Location:271296
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024446723.1XP_024302491.1  zinc finger protein 789 isoform X2

    Conserved Domains (3) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:276413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252272
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_011516073.2XP_011514375.1  zinc finger protein 789 isoform X4

    See identical proteins and their annotated locations for XP_011514375.1

    UniProtKB/Swiss-Prot
    Q5FWF6
    Conserved Domains (2) summary
    COG5048
    Location:158218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164184
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_017012022.1XP_016867511.1  zinc finger protein 789 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:236296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242262
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024446725.1XP_024302493.1  zinc finger protein 789 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:158218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164184
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_024446724.1XP_024302492.1  zinc finger protein 789 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:236296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242262
    ZF_C2H2; C2H2 Zn finger [structural motif]
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