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ZFP82 ZFP82 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 284406, updated on 2-Nov-2024

Summary

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Official Symbol
ZFP82provided by HGNC
Official Full Name
ZFP82 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:28682
See related
Ensembl:ENSG00000181007 AllianceGenome:HGNC:28682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF545
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thyroid (RPKM 1.5), brain (RPKM 1.3) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZFP82 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36383120..36418644, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39058035..39093577, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36874022..36909546, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36818663-36819164 Neighboring gene MPRA-validated peak3460 silencer Neighboring gene ZFP14 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36912605-36913287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919277-36919778 Neighboring gene acyl-CoA thioesterase 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36919779-36920278 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:36939953-36941152 Neighboring gene zinc finger protein 566 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36979559-36980446 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36980447-36981332

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer. Wang S, et al. Gut, 2013 Jun. PMID 22580414
  2. Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer. Xiao Y, et al. PLoS One, 2014. PMID 25360542, Free PMC Article
  3. Poor survival is associated with the methylated degree of zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer. Deng J, et al. Oncotarget, 2015 Feb 28. PMID 25714013, Free PMC Article
  4. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. Xiang S, et al. Int J Oncol, 2017 Sep. PMID 28677721, Free PMC Article
  5. The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis. Ye L, et al. Epigenomics, 2019 Jan. PMID 30211622

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP82 is a tumor suppressor and is disrupted by promoter CpG methylation during esophageal carcinogenesis.
    Title: The 19q13 KRAB Zinc-finger protein ZFP82 suppresses the growth and invasion of esophageal carcinoma cells through inhibiting NF-κB transcription and inducing apoptosis.
  2. ZNF545 protein promoted the apoptosis of myeloma cells.
    Title: The role of MIR-186 and ZNF545 in inhibiting the proliferation of multiple myeloma cells.
  3. the results suggested that ZNF545 functions as a tumor suppressor in colorectal cancer and is frequently inactivated by promoter methylation.
    Title: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer.
  4. These findings indicated that the methylated CpG sites of the ZNF545 promoter could be used for the clinical prediction of the prognosis of gastric cancer
    Title: Poor survival is associated with the methylated degree of zinc-finger protein 545 (ZNF545) DNA promoter in gastric cancer.
  5. ZNF545 inhibits breast tumor cell proliferation through inducing apoptosis and is disrupted by promoter methylation in breast cancer.
    Title: Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer.
  6. ZNF545 acts as a functional tumour suppressor in gastric cancer by inhibiting rRNA transcription.
    Title: Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal RNA transcription in gastric cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1948, MGC45380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 82 homolog
Names
zinc finger protein 545
zinc finger protein 85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321917.2 → NP_001308846.1  zinc finger protein 82 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092296, AL707725, BX491216
    Conserved Domains (3) summary
    smart00349
    Location:6 → 66
    KRAB; krueppel associated box
    COG5048
    Location:144 → 527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001321918.2 → NP_001308847.1  zinc finger protein 82 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092296, BX491216
    Conserved Domains (1) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box

  3. NM_001321919.2 → NP_001308848.1  zinc finger protein 82 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC092296, BX491216
    Conserved Domains (2) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    pfam01352
    Location:6 → 45
    KRAB; KRAB box

  4. NM_133466.4 → NP_597723.1  zinc finger protein 82 homolog isoform 1

    See identical proteins and their annotated locations for NP_597723.1

    Status: VALIDATED

    Source sequence(s)
    AC092296, AL707725, AL834267
    Consensus CDS
    CCDS12493.1
    UniProtKB/Swiss-Prot
    Q8N141, Q8NC63, Q8TF53
    UniProtKB/TrEMBL
    D3Y299
    Related
    ENSP00000431265.1, ENST00000392161.4
    Conserved Domains (3) summary
    smart00349
    Location:6 → 65
    KRAB; krueppel associated box
    COG5048
    Location:143 → 526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:340 → 360
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36383120..36418644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39058035..39093577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N141.1 GenPept UniProtKB/Swiss-Prot:Q8N141

Gene LinkOut

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