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GLG1 golgi glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 2734, updated on 7-Jun-2020

Summary

Official Symbol
GLG1provided by HGNC
Official Full Name
golgi glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:4316
See related
Ensembl:ENSG00000090863 MIM:600753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CFR-1; ESL-1; MG160; MG-160
Expression
Ubiquitous expression in ovary (RPKM 26.0), testis (RPKM 23.5) and 25 other tissues See more
Orthologs

Genomic context

See GLG1 in Genome Data Viewer
Location:
16q23.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (74447440..74607114, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (74481325..74641042, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376772 Neighboring gene uncharacterized LOC107984827 Neighboring gene C-type lectin domain family 18 member B Neighboring gene RNA, U6 small nuclear 237, pseudogene Neighboring gene ribosomal protein S10 pseudogene 23 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 7 Neighboring gene ring finger and WD repeat domain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A pilot genome-wide association study of early-onset breast cancer.
NHGRI GWA Catalog
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GLG1; predicted interaction to be within the Golgi PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23319, FLJ23967, FLJ32797, DKFZp686L08213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of protein processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Golgi apparatus protein 1
Names
E-selectin ligand 1
cysteine-rich fibroblast growth factor receptor
golgi sialoglycoprotein MG-160

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145666.2NP_001139138.1  Golgi apparatus protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001139138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC009053, AK304156, BC060822, BX648396, DA493962
    Consensus CDS
    CCDS45526.1
    UniProtKB/Swiss-Prot
    Q92896
    Related
    ENSP00000406946.2, ENST00000447066.6
    Conserved Domains (1) summary
    pfam00839
    Location:789845
    Cys_rich_FGFR; Cysteine rich repeat
  2. NM_001145667.2NP_001139139.1  Golgi apparatus protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001139139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (3) is shorter at the C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC009053, BC060822, BX648396, U64791
    Consensus CDS
    CCDS45527.1
    UniProtKB/Swiss-Prot
    Q92896
    Related
    ENSP00000405984.2, ENST00000422840.6
    Conserved Domains (1) summary
    pfam00839
    Location:800856
    Cys_rich_FGFR; Cysteine rich repeat
  3. NM_012201.6NP_036333.2  Golgi apparatus protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_036333.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC009053, AK304156, BC060822, BX648396
    Consensus CDS
    CCDS32485.1
    UniProtKB/Swiss-Prot
    Q92896
    Related
    ENSP00000205061.5, ENST00000205061.9
    Conserved Domains (1) summary
    pfam00839
    Location:800856
    Cys_rich_FGFR; Cysteine rich repeat

RNA

  1. NR_027264.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an additional exon in the middle region and an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
    Source sequence(s)
    AC009053, AK027032, AK304156, BX648396, DA493962
  2. NR_027265.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several internal exons and has an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
    Source sequence(s)
    AC009053, BC031836, BC060822, BX648396, DA493962

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    74447440..74607114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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