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Islr immunoglobulin superfamily containing leucine-rich repeat [ Mus musculus (house mouse) ]

Gene ID: 26968, updated on 18-Apr-2024

Summary

Official Symbol
Islrprovided by MGI
Official Full Name
immunoglobulin superfamily containing leucine-rich repeatprovided by MGI
Primary source
MGI:MGI:1349645
See related
Ensembl:ENSMUSG00000037206 AllianceGenome:MGI:1349645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meflin
Summary
Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; meninges; musculature; and retina layer. Orthologous to human ISLR (immunoglobulin superfamily containing leucine rich repeat). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 168.1), mammary gland adult (RPKM 124.5) and 20 other tissues See more
Orthologs
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Genomic context

Location:
9 B; 9 31.63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58063547..58066563, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58156246..58159236, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130 Neighboring gene stimulated by retinoic acid gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57960192-57960379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57981876-57982059 Neighboring gene predicted gene, 39344 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10552 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
immunoglobulin superfamily containing leucine-rich repeat protein
Names
mesenchymal stromal cell- and fibroblast-expressing Linx paralogue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195431.1NP_001182360.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158996, AC160976, AI838480
    Consensus CDS
    CCDS23237.1
    UniProtKB/Swiss-Prot
    Q6GU68
    UniProtKB/TrEMBL
    A0A146E664
    Related
    ENSMUSP00000126963.3, ENSMUST00000168864.4
    Conserved Domains (6) summary
    cd00096
    Location:255341
    Ig; Immunoglobulin domain
    smart00082
    Location:180228
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:50181
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:239343
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:3251
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98158
    LRR_8; Leucine rich repeat
  2. NM_012043.4NP_036173.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158996, AC160976, AI838480
    Consensus CDS
    CCDS23237.1
    UniProtKB/Swiss-Prot
    Q6GU68
    UniProtKB/TrEMBL
    A0A146E664
    Related
    ENSMUSP00000045142.8, ENSMUST00000041477.15
    Conserved Domains (6) summary
    cd00096
    Location:255341
    Ig; Immunoglobulin domain
    smart00082
    Location:180228
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:50181
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:239343
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:3251
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98158
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58063547..58066563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511204.4XP_006511267.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

    Conserved Domains (4) summary
    TIGR00864
    Location:161235
    PCC; polycystin cation channel protein
    sd00033
    Location:4059
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:263349
    Ig; Immunoglobulin domain
    pfam13855
    Location:107166
    LRR_8; Leucine rich repeat
  2. XM_011242750.4XP_011241052.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

    Conserved Domains (4) summary
    TIGR00864
    Location:161235
    PCC; polycystin cation channel protein
    sd00033
    Location:4059
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:263349
    Ig; Immunoglobulin domain
    pfam13855
    Location:107166
    LRR_8; Leucine rich repeat