Sign in to NCBI
Format

Send to:

Choose Destination

ISLR immunoglobulin superfamily containing leucine rich repeat [ Homo sapiens (human) ]

Gene ID: 3671, updated on 23-Nov-2021

Summary

Go to the top of the page Help
Official Symbol
ISLRprovided by HGNC
Official Full Name
immunoglobulin superfamily containing leucine rich repeatprovided by HGNC
Primary source
HGNC:HGNC:6133
See related
Ensembl:ENSG00000129009 MIM:602059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Meflin; HsT17563
Expression
Broad expression in endometrium (RPKM 88.5), ovary (RPKM 76.4) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ISLR in Genome Data Viewer
Location:
15q24.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74173710..74176871)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74466051..74469212)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene COMM domain containing 4 pseudogene 2 Neighboring gene immunoglobulin superfamily containing leucine rich repeat 2 Neighboring gene uncharacterized LOC283731 Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene uncharacterized LOC105370893 Neighboring gene coiled-coil domain containing 33

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). Nagasawa A, et al. Genomics, 1997 Sep 15. PMID 9325048
  2. The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis. Kobayashi H, et al. Gastroenterology, 2021 Mar. PMID 33197448
  3. Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives. Miyai Y, et al. Cancer Sci, 2020 Apr. PMID 32060987, Free PMC Article
  4. Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis. Mizutani Y, et al. Cancer Res, 2019 Oct 15. PMID 31439548
  5. Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction. Hara A, et al. Circ Res, 2019 Aug 2. PMID 31221024

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
    Title: The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.
  2. Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.
    Title: Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.
  3. Meflin is expressed by pancreatic stellate cells that are a source of cancer-associated fibroblasts in pancreatic ductal adenocarcinoma. Delivery of a Meflin-expressing lentivirus into the tumor stroma or overexpression of Meflin in CAFs suppressed the growth of xenograft tumors. Meflin deficiency or low expression resulted in straightened stromal collagen fibers, a signature for aggressive tumors, in human PDAC tissues.
    Title: Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC102816

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
immunoglobulin superfamily containing leucine-rich repeat protein
Names
mesenchymal stromal cell- and fibroblast-expressing Linx paralogue

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005545.4 → NP_005536.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    See identical proteins and their annotated locations for NP_005536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB024536, AC023545, BR001380
    Consensus CDS
    CCDS10260.1
    UniProtKB/Swiss-Prot
    O14498
    UniProtKB/TrEMBL
    A0A146E5L3
    Related
    ENSP00000249842.3, ENST00000249842.8
    Conserved Domains (4) summary
    TIGR00864
    Location:153 → 227
    PCC; polycystin cation channel protein
    sd00033
    Location:32 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98 → 158
    LRR_8; Leucine rich repeat
    cl28434
    Location:239 → 340
    I-set; Immunoglobulin I-set domain

  2. NM_201526.2 → NP_958934.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    See identical proteins and their annotated locations for NP_958934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB003184, AC023545, BR001380
    Consensus CDS
    CCDS10260.1
    UniProtKB/Swiss-Prot
    O14498
    UniProtKB/TrEMBL
    A0A146E5L3
    Related
    ENSP00000378550.1, ENST00000395118.1
    Conserved Domains (4) summary
    TIGR00864
    Location:153 → 227
    PCC; polycystin cation channel protein
    sd00033
    Location:32 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98 → 158
    LRR_8; Leucine rich repeat
    cl28434
    Location:239 → 340
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74173710..74176871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160016.1 Reference GRCh38.p13 PATCHES

    Range
    1135..4296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14498.1 GenPept UniProtKB/Swiss-Prot:O14498

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center