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ISLR immunoglobulin superfamily containing leucine rich repeat [ Homo sapiens (human) ]

Gene ID: 3671, updated on 23-Nov-2021

Summary

Official Symbol
ISLRprovided by HGNC
Official Full Name
immunoglobulin superfamily containing leucine rich repeatprovided by HGNC
Primary source
HGNC:HGNC:6133
See related
Ensembl:ENSG00000129009 MIM:602059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Meflin; HsT17563
Expression
Broad expression in endometrium (RPKM 88.5), ovary (RPKM 76.4) and 22 other tissues See more
Orthologs
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Genomic context

See ISLR in Genome Data Viewer
Location:
15q24.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74173710..74176871)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74466051..74469212)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene COMM domain containing 4 pseudogene 2 Neighboring gene immunoglobulin superfamily containing leucine rich repeat 2 Neighboring gene uncharacterized LOC283731 Neighboring gene signaling receptor and transporter of retinol STRA6 Neighboring gene uncharacterized LOC105370893 Neighboring gene coiled-coil domain containing 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102816

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
immunoglobulin superfamily containing leucine-rich repeat protein
Names
mesenchymal stromal cell- and fibroblast-expressing Linx paralogue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005545.4NP_005536.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    See identical proteins and their annotated locations for NP_005536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB024536, AC023545, BR001380
    Consensus CDS
    CCDS10260.1
    UniProtKB/Swiss-Prot
    O14498
    UniProtKB/TrEMBL
    A0A146E5L3
    Related
    ENSP00000249842.3, ENST00000249842.8
    Conserved Domains (4) summary
    TIGR00864
    Location:153227
    PCC; polycystin cation channel protein
    sd00033
    Location:3251
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98158
    LRR_8; Leucine rich repeat
    cl28434
    Location:239340
    I-set; Immunoglobulin I-set domain
  2. NM_201526.2NP_958934.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    See identical proteins and their annotated locations for NP_958934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB003184, AC023545, BR001380
    Consensus CDS
    CCDS10260.1
    UniProtKB/Swiss-Prot
    O14498
    UniProtKB/TrEMBL
    A0A146E5L3
    Related
    ENSP00000378550.1, ENST00000395118.1
    Conserved Domains (4) summary
    TIGR00864
    Location:153227
    PCC; polycystin cation channel protein
    sd00033
    Location:3251
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98158
    LRR_8; Leucine rich repeat
    cl28434
    Location:239340
    I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74173710..74176871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160016.1 Reference GRCh38.p13 PATCHES

    Range
    1135..4296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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