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IL1RAPL2 interleukin 1 receptor accessory protein like 2 [ Homo sapiens (human) ]

Gene ID: 26280, updated on 12-Aug-2018

Summary

Official Symbol
IL1RAPL2provided by HGNC
Official Full Name
interleukin 1 receptor accessory protein like 2provided by HGNC
Primary source
HGNC:HGNC:5997
See related
Ensembl:ENSG00000189108 MIM:300277; Vega:OTTHUMG00000022141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL1R9; IL-1R9; TIGIRR-1; IL1RAPL-2
Summary
The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See IL1RAPL2 in Genome Data Viewer
Location:
Xq22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (104566315..105769729)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103810996..105011822)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 199, X-linked Neighboring gene ESX homeobox 1 Neighboring gene prohibitin pseudogene 10 Neighboring gene ribosomal protein L18a pseudogene 14 Neighboring gene testis expressed 13A Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 2 Neighboring gene uncharacterized LOC107985680 Neighboring gene uncharacterized LOC105373303 Neighboring gene RNA, U6 small nuclear 207, pseudogene Neighboring gene uncharacterized LOC105373304 Neighboring gene HNF1 motif-containing MPRA enhancer 3 Neighboring gene uncharacterized LOC105373305 Neighboring gene Nik related kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor activity TAS
Traceable Author Statement
more info
PubMed 
interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of presynapse assembly EXP
Inferred from Experiment
more info
PubMed 
regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
X-linked interleukin-1 receptor accessory protein-like 2
Names
IL-1 receptor accessory protein-like 2
IL-1R-9
IL1RAPL-2-related protein
interleukin 1 receptor 9
three immunoglobulin domain-containing IL-1 receptor-related 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012566.3 RefSeqGene

    Range
    5001..1206515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017416.1NP_059112.1  X-linked interleukin-1 receptor accessory protein-like 2 precursor

    See identical proteins and their annotated locations for NP_059112.1

    Status: REVIEWED

    Source sequence(s)
    AJ272208
    Consensus CDS
    CCDS14517.1
    UniProtKB/Swiss-Prot
    Q9NP60
    Related
    ENSP00000361663.1, OTTHUMP00000023775, ENST00000372582.5, OTTHUMT00000057785
    Conserved Domains (4) summary
    smart00410
    Location:250347
    IG_like; Immunoglobulin like
    pfam01582
    Location:402563
    TIR; TIR domain
    cd05757
    Location:146237
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cl11960
    Location:32133
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    104566315..105769729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530905.2XP_011529207.1  X-linked interleukin-1 receptor accessory protein-like 2 isoform X1

    Conserved Domains (4) summary
    cd00096
    Location:137220
    Ig; Immunoglobulin domain
    cd05757
    Location:22113
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:277435
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:126223
    IG_like; Immunoglobulin like
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