U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il1rapl2 interleukin 1 receptor accessory protein-like 2 [ Mus musculus (house mouse) ]

Gene ID: 60367, updated on 26-Sep-2022

Summary

Official Symbol
Il1rapl2provided by MGI
Official Full Name
interleukin 1 receptor accessory protein-like 2provided by MGI
Primary source
MGI:MGI:1913106
See related
Ensembl:ENSMUSG00000059203 AllianceGenome:MGI:1913106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable NAD(P)+ nucleosidase activity; NAD+ nucleotidase, cyclic ADP-ribose generating; and interleukin-1, type II, blocking receptor activity. Predicted to be involved in regulation of presynapse assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Is expressed in brain and spinal cord floor plate. Orthologous to human IL1RAPL2 (interleukin 1 receptor accessory protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Il1rapl2 in Genome Data Viewer
Location:
X; X F1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (136471503..137749826)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (137570754..138849077)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger, ZZ domain containing 3 pseudogene Neighboring gene predicted gene 8036 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene testis expressed 13A Neighboring gene predicted gene, 22057 Neighboring gene predicted gene, 23958 Neighboring gene zinc finger protein 259 pseudogene Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 Neighboring gene Nik related kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-1, type II, blocking receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
X-linked interleukin-1 receptor accessory protein-like 2
Names
IL-1 receptor accessory protein-like 2
IL-1-RAPL-2
IL-1RAPL-2
IL1RAPL-2
IL1RAPL-2-related protein
TIGIRR-1
three immunoglobulin domain-containing IL-1 receptor-related 1
NP_109613.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030688.2NP_109613.1  X-linked interleukin-1 receptor accessory protein-like 2 precursor

    See identical proteins and their annotated locations for NP_109613.1

    Status: VALIDATED

    Source sequence(s)
    AK045976, AL672067
    Consensus CDS
    CCDS30429.1
    UniProtKB/Swiss-Prot
    Q9ER66, Q9ERS6
    UniProtKB/TrEMBL
    A0A6P5P492, Q0VBP3
    Related
    ENSMUSP00000108686.2, ENSMUST00000113063.8
    Conserved Domains (4) summary
    cd05896
    Location:32133
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    smart00255
    Location:401559
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:250347
    IG_like; Immunoglobulin like
    cd05757
    Location:146237
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    136471503..137749826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)