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FUT8 fucosyltransferase 8 [ Homo sapiens (human) ]

Gene ID: 2530, updated on 11-Sep-2019

Summary

Official Symbol
FUT8provided by HGNC
Official Full Name
fucosyltransferase 8provided by HGNC
Primary source
HGNC:HGNC:4019
See related
Ensembl:ENSG00000033170 MIM:602589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDGF; CDGF1
Summary
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in stomach (RPKM 6.3), brain (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See FUT8 in Genome Data Viewer
Location:
14q23.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (65410592..65744122)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65877310..66210839)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 4708 Neighboring gene uncharacterized LOC105370537 Neighboring gene FUT8 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 8 Neighboring gene microRNA 625 Neighboring gene EIF1AX pseudogene 2 Neighboring gene uncharacterized LOC107984641 Neighboring gene nuclear receptor coactivator 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Congenital disorder of glycosylation with defective fucosylation 1
MedGen: CN258220 OMIM: 618005 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1α as a master regulator of plasma protein fucosylation.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with FUT8; predicted interaction to be within the Golgi PubMed
env HIV-1 gp160 is identified to have a physical interaction with fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (FUT8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26465

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
alpha-(1->6)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycoprotein 6-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein 6-alpha-L-fucosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
GDP-L-fucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
L-fucose catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
N-glycan fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-glycan processing TAS
Traceable Author Statement
more info
PubMed 
cell migration IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development NAS
Non-traceable Author Statement
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation in Golgi IEA
Inferred from Electronic Annotation
more info
 
receptor metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus NAS
Non-traceable Author Statement
more info
PubMed 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
alpha-(1,6)-fucosyltransferase
Names
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
alpha1-6FucT
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
glycoprotein 6-alpha-L-fucosyltransferase
NP_001358462.1
NP_001358463.1
NP_001358465.1
NP_004471.4
NP_835368.1
NP_835369.1
XP_011534916.1
XP_016876625.1
XP_016876627.1
XP_016876628.1
XP_016876629.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371533.1NP_001358462.1  alpha-(1,6)-fucosyltransferase isoform a

    Status: REVIEWED

    Source sequence(s)
    AB049740, AF052088, AL109847, AL161871, DB089189, Y17978
  2. NM_001371534.1NP_001358463.1  alpha-(1,6)-fucosyltransferase isoform a

    Status: REVIEWED

    Source sequence(s)
    AL109847, AL161871, AL355840, AL359236
  3. NM_001371536.1NP_001358465.1  alpha-(1,6)-fucosyltransferase isoform c

    Status: REVIEWED

    Source sequence(s)
    AL109847, AL161871, AL355840, AL359236
  4. NM_004480.4NP_004471.4  alpha-(1,6)-fucosyltransferase isoform b

    See identical proteins and their annotated locations for NP_004471.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AJ536056, AK294242, AL109847, AL359236, BX107537
    Consensus CDS
    CCDS9776.2
    UniProtKB/Swiss-Prot
    Q9BYC5
    UniProtKB/TrEMBL
    Q546E0
    Related
    ENSP00000452433.1, ENST00000557164.5
    Conserved Domains (2) summary
    cd11300
    Location:11336
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:343397
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
  5. NM_178155.3NP_835368.1  alpha-(1,6)-fucosyltransferase isoform a

    See identical proteins and their annotated locations for NP_835368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as B6) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AJ536053, AK292413, AL109847, AL359236, BX107537
    Consensus CDS
    CCDS9775.1
    UniProtKB/Swiss-Prot
    Q9BYC5
    UniProtKB/TrEMBL
    A8K8P8, Q546E0
    Related
    ENSP00000353910.5, ENST00000360689.9
    Conserved Domains (3) summary
    cd11300
    Location:174499
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:506560
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
    cl26819
    Location:50152
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
  6. NM_178156.2NP_835369.1  alpha-(1,6)-fucosyltransferase isoform a

    See identical proteins and their annotated locations for NP_835369.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as B5) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AJ536055, AJ536056, AL109847, AL161871, AL359236, BX107537
    Consensus CDS
    CCDS9775.1
    UniProtKB/Swiss-Prot
    Q9BYC5
    UniProtKB/TrEMBL
    Q546E0
    Related
    ENSP00000378087.2, ENST00000394586.6
    Conserved Domains (3) summary
    cd11300
    Location:174499
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:506560
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
    cl26819
    Location:50152
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

RNA

  1. NR_038167.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two consecutive exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ536056, AL109847, AL161871, AL359236, BC142958, BX107537

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    65410592..65744122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021138.1XP_016876627.1  alpha-(1,6)-fucosyltransferase isoform X1

  2. XM_017021136.1XP_016876625.1  alpha-(1,6)-fucosyltransferase isoform X1

  3. XM_017021139.1XP_016876628.1  alpha-(1,6)-fucosyltransferase isoform X1

  4. XM_017021140.1XP_016876629.1  alpha-(1,6)-fucosyltransferase isoform X2

  5. XM_011536614.3XP_011534916.1  alpha-(1,6)-fucosyltransferase isoform X3

    Conserved Domains (2) summary
    cd11300
    Location:1268
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:275329
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178154.1: Suppressed sequence

    Description
    NM_178154.1: This RefSeq was permanently suppressed because the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_178157.1: Suppressed sequence

    Description
    NM_178157.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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