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Fut8 fucosyltransferase 8 [ Mus musculus (house mouse) ]

Gene ID: 53618, updated on 10-Oct-2019

Summary

Official Symbol
Fut8provided by MGI
Official Full Name
fucosyltransferase 8provided by MGI
Primary source
MGI:MGI:1858901
See related
Ensembl:ENSMUSG00000021065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Ubiquitous expression in adrenal adult (RPKM 7.1), cerebellum adult (RPKM 6.8) and 28 other tissues See more
Orthologs

Genomic context

See Fut8 in Genome Data Viewer
Location:
12; 12 C3
Exon count:
17
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (77237430..77475998)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (78340008..78576974)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35189 Neighboring gene predicted gene, 40446 Neighboring gene RIKEN cDNA 9530018F02 gene Neighboring gene U6 spliceosomal RNA Neighboring gene U1 spliceosomal RNA Neighboring gene protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene Neighboring gene Shwachman-Bodian-Diamond syndrome homolog pseudogene Neighboring gene predicted gene, 35240 Neighboring gene histone deacetylase 1 pseudogene Neighboring gene predicted gene, 35440

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
alpha-(1->6)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-(1->6)-fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycoprotein 6-alpha-L-fucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring glycosyl groups ISA
Inferred from Sequence Alignment
more info
PubMed 
Process Evidence Code Pubs
GDP-L-fucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
N-glycan fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-glycan fucosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
N-glycan processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
 
protein glycosylation in Golgi IEA
Inferred from Electronic Annotation
more info
 
receptor metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
respiratory gaseous exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
alpha-(1,6)-fucosyltransferase
Names
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
alpha1-6FucT
glycoprotein 6-alpha-L-fucosyltransferase
NP_001239543.1
NP_001239544.1
NP_001239545.1
NP_058589.2
XP_011242446.1
XP_011242447.1
XP_030102681.1
XP_030102682.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252614.1NP_001239543.1  alpha-(1,6)-fucosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_001239543.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC110302, AC132342, AC159296
    Consensus CDS
    CCDS25999.1
    UniProtKB/Swiss-Prot
    Q9WTS2
    Related
    ENSMUSP00000136327.1, ENSMUST00000177595.8
    Conserved Domains (2) summary
    cd11300
    Location:174499
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:506560
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
  2. NM_001252615.1NP_001239544.1  alpha-(1,6)-fucosyltransferase isoform 2

    See identical proteins and their annotated locations for NP_001239544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK048520, CJ320809, EF591874
    UniProtKB/Swiss-Prot
    Q9WTS2
    UniProtKB/TrEMBL
    B2X2D7
    Conserved Domains (2) summary
    cd11300
    Location:11336
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:343397
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
  3. NM_001252616.1NP_001239545.1  alpha-(1,6)-fucosyltransferase isoform 3

    See identical proteins and their annotated locations for NP_001239545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK048520, CJ320809, EF591875
    UniProtKB/Swiss-Prot
    Q9WTS2
    UniProtKB/TrEMBL
    B2X2D8
    Conserved Domains (2) summary
    cd11300
    Location:10310
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:317371
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
  4. NM_016893.5NP_058589.2  alpha-(1,6)-fucosyltransferase isoform 1

    See identical proteins and their annotated locations for NP_058589.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK048520, AK051811, BU702757, CJ320809
    Consensus CDS
    CCDS25999.1
    UniProtKB/Swiss-Prot
    Q9WTS2
    Related
    ENSMUSP00000130845.2, ENSMUST00000171770.9
    Conserved Domains (2) summary
    cd11300
    Location:174499
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:506560
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)

RNA

  1. NR_045554.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has an alternate 5' exon, which contains an upstream ORF with a strong Kozak signal, compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record, but is predicted to be non-coding because the upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK048520, AK051811, AK134537, CJ070536

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p6 C57BL/6J

    Range
    77237430..77475998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246822.1XP_030102682.1  alpha-(1,6)-fucosyltransferase isoform X2

  2. XM_011244145.3XP_011242447.1  alpha-(1,6)-fucosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011242447.1

    UniProtKB/Swiss-Prot
    Q9WTS2
    Conserved Domains (2) summary
    cd11300
    Location:174499
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:506560
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
  3. XM_011244144.3XP_011242446.1  alpha-(1,6)-fucosyltransferase isoform X1

    See identical proteins and their annotated locations for XP_011242446.1

    UniProtKB/Swiss-Prot
    Q9WTS2
    Related
    ENSMUSP00000054530.7, ENSMUST00000062804.7
    Conserved Domains (2) summary
    cd11300
    Location:174499
    Fut8_like; Alpha 1-6-fucosyltransferase
    cd11792
    Location:506560
    SH3_Fut8; Src homology 3 domain of Alpha1,6-fucosyltransferase (Fut8)
  4. XM_030246821.1XP_030102681.1  alpha-(1,6)-fucosyltransferase isoform X2

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