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Tlr2 toll-like receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 24088, updated on 20-Feb-2024

Summary

Official Symbol
Tlr2provided by MGI
Official Full Name
toll-like receptor 2provided by MGI
Primary source
MGI:MGI:1346060
See related
Ensembl:ENSMUSG00000027995 AllianceGenome:MGI:1346060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly105
Summary
Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 3.8), bladder adult (RPKM 3.5) and 24 other tissues See more
Orthologs
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Genomic context

See Tlr2 in Genome Data Viewer
Location:
3 E3; 3 37.4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (83743579..83749045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (83836272..83841824, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene secreted frizzled-related protein 2 Neighboring gene ring finger protein 175 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08062 Neighboring gene STARR-seq mESC enhancer starr_08063 Neighboring gene transmembrane 131 like Neighboring gene STARR-seq mESC enhancer starr_08065 Neighboring gene STARR-positive B cell enhancer ABC_E518 Neighboring gene STARR-positive B cell enhancer ABC_E4548 Neighboring gene predicted gene, 30352

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Toll-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables diacyl lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopeptide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables triacyl lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triacyl lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables triacyl lipopeptide binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within MyD88-dependent toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to bacterial lipopeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to bacterial lipopeptide TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipoteichoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipoteichoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of diacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglia development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synapse assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nitric oxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-18 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of dendritic cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to bacterial lipoprotein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to molecule of fungal origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor TLR6:TLR2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
toll-like receptor 2
NP_036035.3
XP_006501523.1
XP_030108471.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011905.3NP_036035.3  toll-like receptor 2 precursor

    See identical proteins and their annotated locations for NP_036035.3

    Status: VALIDATED

    Source sequence(s)
    AK005043, BP771904, BY743020
    Consensus CDS
    CCDS17435.1
    UniProtKB/Swiss-Prot
    Q3U400, Q9DBC4, Q9QUN7
    UniProtKB/TrEMBL
    G3X8Y8
    Related
    ENSMUSP00000029623.10, ENSMUST00000029623.11
    Conserved Domains (7) summary
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:55151
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:5577
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:176202
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:459494
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl15307
    Location:533586
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    83743579..83749045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501460.4XP_006501523.1  toll-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3U400, Q9DBC4, Q9QUN7
    Conserved Domains (7) summary
    PRK15370
    Location:350568
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:650794
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:6587
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:186212
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:87145
    LRR_8; Leucine rich repeat
    NF033189
    Location:58259
    internalin_A; class 1 internalin InlA
    cl15307
    Location:543596
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. XM_030252611.2XP_030108471.1  toll-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3U400, Q9DBC4, Q9QUN7
    Conserved Domains (7) summary
    PRK15370
    Location:350568
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:650794
    TIR; Toll - interleukin 1 - resistance
    sd00031
    Location:6587
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:186212
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:87145
    LRR_8; Leucine rich repeat
    NF033189
    Location:58259
    internalin_A; class 1 internalin InlA
    cl15307
    Location:543596
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain