TLR2 toll like receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TLR2provided by HGNC
Official Full Name: toll like receptor 2provided by HGNC
Primary source: HGNC:HGNC:11848
See related: Ensembl:ENSG00000137462 MIM:603028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIL4; CD282
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Broad expression in appendix (RPKM 15.9), bone marrow (RPKM 12.6) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q31.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20210226	current	GRCh38.p13 (GCF_000001405.39)	4	NC_000004.12 (153684080..153710643)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (154605432..154627412)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies.
Title: Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies.
Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
Title: Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release of H. pylori-Infected Human DCs.
Title: TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release of H. pylori-Infected Human DCs.
Paracoccidioides brasiliensis downmodulates alpha3 integrin levels in human lung epithelial cells in a TLR2-dependent manner.
Title: Paracoccidioides brasiliensis downmodulates α3 integrin levels in human lung epithelial cells in a TLR2-dependent manner.
Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis.
Title: Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis.
Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1.
Title: Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1.
Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients.
Title: Arg753Gln Polymorphisms in the Toll-Like Receptor 2 Gene are Associated with Cytomegalovirus Infection in Egyptian Bone Marrow Recipients.
TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm.
Title: TLR2 2029C/T and TLR3 1377C/T and -7C/A Polymorphisms Are Associated with the Occurrence of Abdominal Aortic Aneurysm.
Toll-Like Receptor 2 Expression as a New Hallmark of Advanced Endometriosis.
Title: Toll-Like Receptor 2 Expression as a New Hallmark of Advanced Endometriosis.
TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones.
Title: TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones.

Submit: New GeneRIF Correction See all GeneRIFs (1278)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0009402 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs
Leprosy 3 MedGen: C1968668 OMIM: 246300 GeneReviews: Not available	Compare labs
Mycobacterium tuberculosis, susceptibility to MedGen: C1834752 OMIM: 607948 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 replication is enhanced by TLR2; when neutralized with anti-TLR2 antibody HIV-1 (BAL) proviral DNA is decreased relative to non-specific antibody in TZM-bl-2 cells	PubMed
HIV-1 infection is enhanced by TLR2 stimulation via Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) in TZM-bl cells	PubMed
HIV-1 replication is enhanced by TLR2 stimulation or TNF treatment in Langerhans cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation	PubMed
	env	Treatment of HIV-1 gp120 to astroglia displays significant increases in TLR2	PubMed
Envelope transmembrane glycoprotein gp41	env	Fully processed HIV-1 Env protein, once expressed on the cellular membrane, inhibits TLR2 activation	PubMed
	env	HIV-1 gp41 binds TLR2 (from TZM-bl-2 cell lysates)	PubMed
	env	siRNA knockdown of TLR2 in a HIV-1 gp41-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production	PubMed
	env	Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 gp41 decreases IL-8 production	PubMed
	env	Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases the production of IL-8	PubMed
	env	The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro	PubMed
	env	The transmembrane domain (TMD) of HIV-1 gp41 directly interacts with the TLR2 TMD within the membrane, partially through its GxxxG dimerization motif	PubMed
	env	The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6	PubMed
	env	The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells	PubMed
Nef	nef	HIV-1 Nef-mediated upregulation of TLR2 increases regulatory T cells (Tregs) and inhibits the proliferation of PBMCs	PubMed
	nef	HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells	PubMed
Tat	tat	Treatment of HIV-1 Tat to astroglia displays significant increases in TLR2 expression	PubMed
capsid	gag	HIV-1 CA binds TLR2 (from TZM-bl-2 cell lysates)	PubMed
	gag	Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases the production of IL-8 BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1	PubMed
	gag	Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 CA (p24) decreases IL-8 production	PubMed
	gag	The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells	PubMed
matrix	gag	HIV-1 MA (p17) binds TLR2 (from TZM-bl-2 cell lysates)	PubMed
	gag	siRNA knockdown of TLR2 in a HIV-1 MA (p17)-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production	PubMed
	gag	Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 MA (p17) decreases IL-8 production	PubMed
	gag	Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8	PubMed
	gag	The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC98129P1 (e-PCR)
- UniSTS:273665

PMC98226P1 (e-PCR)
- UniSTS:273667

PMC98510P1 (e-PCR)
- UniSTS:273671

PMC201071P1 (e-PCR)
- UniSTS:271880

D4S660 (e-PCR)
- UniSTS:95274

D4S841 (e-PCR)
- UniSTS:32812

TLR2 (e-PCR)
- UniSTS:503343

D4S575 (e-PCR)
- UniSTS:35904

G34296 (e-PCR)
- UniSTS:1092

SHGC4-1535 (e-PCR)
- UniSTS:51781

TLR2_1084.2 (e-PCR)
- UniSTS:466509

SHGC-33147 (e-PCR)
- UniSTS:62605

PMC37511P1 (e-PCR)
- UniSTS:273305

TLR2 (e-PCR)
- UniSTS:277943

AF368419 (e-PCR)
- UniSTS:277943

PMC55404P2 (e-PCR)
- UniSTS:273341

PMC128073P3 (e-PCR)
- UniSTS:270565

PMC97725P1 (e-PCR)
- UniSTS:273658

Homology

Homologs of the TLR2 gene: The TLR2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 271 organisms have orthologs with human gene TLR2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NAD(P)+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
Toll-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
lipopolysaccharide immune receptor activity	TAS Traceable Author Statement more info	PubMed
pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
triacyl lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
triacyl lipopeptide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
I-kappaB phosphorylation	IDA Inferred from Direct Assay more info	PubMed
MyD88-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
apoptotic process	TAS Traceable Author Statement more info	PubMed
cell activation	IDA Inferred from Direct Assay more info	PubMed
cellular response to bacterial lipopeptide	TAS Traceable Author Statement more info	PubMed
cellular response to diacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
cellular response to interferon-gamma	IDA Inferred from Direct Assay more info	PubMed
cellular response to lipoteichoic acid	IDA Inferred from Direct Assay more info	PubMed
cellular response to lipoteichoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to triacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
central nervous system myelin formation	IEA Inferred from Electronic Annotation more info
defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
detection of diacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
detection of triacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
immune response	TAS Traceable Author Statement more info	PubMed
inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
innate immune response	TAS Traceable Author Statement more info	PubMed
interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
learning	ISS Inferred from Sequence or Structural Similarity more info
leukotriene metabolic process	IEA Inferred from Electronic Annotation more info
lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
microglia development	ISS Inferred from Sequence or Structural Similarity more info
microglial cell activation	IEA Inferred from Electronic Annotation more info
negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
neutrophil degranulation	TAS Traceable Author Statement more info
nitric oxide metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NIK/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular response to macrophage colony-stimulating factor stimulus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of inflammatory response	IC Inferred by Curator more info	PubMed
positive regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-18 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-8 production	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of matrix metallopeptidase secretion	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of nitric-oxide synthase biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
response to fatty acid	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to insulin	IEA Inferred from Electronic Annotation more info
response to progesterone	IEA Inferred from Electronic Annotation more info
response to toxic substance	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
toll-like receptor 2 signaling pathway	IEA Inferred from Electronic Annotation more info
toll-like receptor TLR1:TLR2 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor TLR6:TLR2 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
toll-like receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
Toll-like receptor 1-Toll-like receptor 2 protein complex	IDA Inferred from Direct Assay more info	PubMed
cell body	IEA Inferred from Electronic Annotation more info
cell projection	IEA Inferred from Electronic Annotation more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
intrinsic component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
membrane raft	IDA Inferred from Direct Assay more info	PubMed
phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: toll-like receptor 2

Names: toll/interleukin-1 receptor-like protein 4

NP_001305716.1

EC 3.2.2.6

NP_001305718.1

EC 3.2.2.6

NP_001305719.1

EC 3.2.2.6

NP_001305720.1

EC 3.2.2.6

NP_001305722.1

EC 3.2.2.6

NP_001305724.1

EC 3.2.2.6

NP_001305725.1

EC 3.2.2.6

NP_003255.2

EC 3.2.2.6

XP_011530517.1

EC 3.2.2.6

XP_011530518.1

EC 3.2.2.6

XP_016864062.1

EC 3.2.2.6

XP_016864063.1

EC 3.2.2.6

XP_016864064.1

EC 3.2.2.6

XP_016864065.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016229.1 RefSeqGene

Range

4992..26972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001318787.2 → NP_001305716.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 all encode the same protein.

Source sequence(s)

AK125659, AW614989, BC033756, BQ017238, CB528396, DA582193

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Related

ENSP00000260010.6, ENST00000260010.6

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318789.2 → NP_001305718.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Related

ENSP00000494425.1, ENST00000642700.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318790.2 → NP_001305719.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA870971

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318791.2 → NP_001305720.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424052, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318793.2 → NP_001305722.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA460298

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318795.2 → NP_001305724.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424053, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318796.2 → NP_001305725.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424049, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Related

ENSP00000495339.1, ENST00000642580.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_003264.5 → NP_003255.2 toll-like receptor 2 precursor

See identical proteins and their annotated locations for NP_003255.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424049, AI493140, AW614989, BC033756, BQ017238, DQ012267

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p13 Primary Assembly

Range

153684080..153710643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008573.1 → XP_016864062.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_017008574.1 → XP_016864063.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_017008575.1 → XP_016864064.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_011532215.2 → XP_011530517.1 toll-like receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011530517.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_011532216.2 → XP_011530518.1 toll-like receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011530518.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_017008576.1 → XP_016864065.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional