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TLR2 toll like receptor 2 [ Homo sapiens (human) ]

Gene ID: 7097, updated on 24-May-2020

Summary

Official Symbol
TLR2provided by HGNC
Official Full Name
toll like receptor 2provided by HGNC
Primary source
HGNC:HGNC:11848
See related
Ensembl:ENSG00000137462 MIM:603028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIL4; CD282
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Broad expression in appendix (RPKM 15.9), bone marrow (RPKM 12.6) and 18 other tissues See more
Orthologs

Genomic context

See TLR2 in Genome Data Viewer
Location:
4q31.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (153684080..153710643)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154605404..154627243)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane 131 like Neighboring gene uncharacterized LOC105377498 Neighboring gene toll like receptor 2 pseudogene Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene uncharacterized LOC105377499 Neighboring gene ring finger protein 175 Neighboring gene secreted frizzled related protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication is enhanced by TLR2; when neutralized with anti-TLR2 antibody HIV-1 (BAL) proviral DNA is decreased relative to non-specific antibody in TZM-bl-2 cells PubMed
HIV-1 infection is enhanced by TLR2 stimulation via Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) in TZM-bl cells PubMed
HIV-1 replication is enhanced by TLR2 stimulation or TNF treatment in Langerhans cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation PubMed
env Treatment of HIV-1 gp120 to astroglia displays significant increases in TLR2 PubMed
Envelope transmembrane glycoprotein gp41 env Fully processed HIV-1 Env protein, once expressed on the cellular membrane, inhibits TLR2 activation PubMed
env HIV-1 gp41 binds TLR2 (from TZM-bl-2 cell lysates) PubMed
env siRNA knockdown of TLR2 in a HIV-1 gp41-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production PubMed
env Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 gp41 decreases IL-8 production PubMed
env Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases the production of IL-8 PubMed
env The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro PubMed
env The transmembrane domain (TMD) of HIV-1 gp41 directly interacts with the TLR2 TMD within the membrane, partially through its GxxxG dimerization motif PubMed
env The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6 PubMed
env The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed
Nef nef HIV-1 Nef-mediated upregulation of TLR2 increases regulatory T cells (Tregs) and inhibits the proliferation of PBMCs PubMed
nef HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells PubMed
Tat tat Treatment of HIV-1 Tat to astroglia displays significant increases in TLR2 expression PubMed
capsid gag HIV-1 CA binds TLR2 (from TZM-bl-2 cell lysates) PubMed
gag Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases the production of IL-8 BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1 PubMed
gag Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 CA (p24) decreases IL-8 production PubMed
gag The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed
matrix gag HIV-1 MA (p17) binds TLR2 (from TZM-bl-2 cell lysates) PubMed
gag siRNA knockdown of TLR2 in a HIV-1 MA (p17)-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production PubMed
gag Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 MA (p17) decreases IL-8 production PubMed
gag Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8 PubMed
gag The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopolysaccharide receptor activity TAS
Traceable Author Statement
more info
PubMed 
pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triacyl lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triacyl lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
I-kappaB phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell activation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to bacterial lipopeptide TAS
Traceable Author Statement
more info
PubMed 
cellular response to diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipoteichoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to triacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system myelin formation IEA
Inferred from Electronic Annotation
more info
 
cytokine secretion involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of diacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
detection of triacyl bacterial lipopeptide IDA
Inferred from Direct Assay
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
learning ISS
Inferred from Sequence or Structural Similarity
more info
 
leukotriene metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
microglia development ISS
Inferred from Sequence or Structural Similarity
more info
 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nitric oxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular response to macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
positive regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-18 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of matrix metallopeptidase secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
toll-like receptor 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor TLR1:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Toll-like receptor 1-Toll-like receptor 2 protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cell body IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
toll-like receptor 2
Names
toll/interleukin-1 receptor-like protein 4
NP_001305716.1
NP_001305718.1
NP_001305719.1
NP_001305720.1
NP_001305722.1
NP_001305724.1
NP_001305725.1
NP_003255.2
XP_011530517.1
XP_011530518.1
XP_016864062.1
XP_016864063.1
XP_016864064.1
XP_016864065.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016229.1 RefSeqGene

    Range
    4992..26972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318787.2NP_001305716.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AK125659, AW614989, BC033756, BQ017238, CB528396, DA582193
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Related
    ENSP00000260010.6, ENST00000260010.6
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. NM_001318789.2NP_001305718.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Related
    ENSP00000494425.1, ENST00000642700.1
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  3. NM_001318790.2NP_001305719.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA870971
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. NM_001318791.2NP_001305720.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424052, AK125659, AW614989, BC033756, BQ017238, CB528396
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  5. NM_001318793.2NP_001305722.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA460298
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  6. NM_001318795.2NP_001305724.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424053, AK125659, AW614989, BC033756, BQ017238, CB528396
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  7. NM_001318796.2NP_001305725.1  toll-like receptor 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424049, AK125659, AW614989, BC033756, BQ017238, CB528396
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4, B3KWR9
    Related
    ENSP00000495339.1, ENST00000642580.1
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  8. NM_003264.5NP_003255.2  toll-like receptor 2 precursor

    See identical proteins and their annotated locations for NP_003255.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.
    Source sequence(s)
    AF424049, AI493140, AW614989, BC033756, BQ017238, DQ012267
    Consensus CDS
    CCDS3784.1
    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    153684080..153710643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008573.1XP_016864062.1  toll-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  2. XM_017008574.1XP_016864063.1  toll-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  3. XM_017008575.1XP_016864064.1  toll-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  4. XM_011532215.2XP_011530517.1  toll-like receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011530517.1

    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  5. XM_011532216.2XP_011530518.1  toll-like receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011530518.1

    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
  6. XM_017008576.1XP_016864065.1  toll-like receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    O60603
    UniProtKB/TrEMBL
    A0A0S2Z4S4
    Conserved Domains (6) summary
    smart00082
    Location:533586
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    TIR; Toll - interleukin 1 - resistance
    sd00033
    Location:5477
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:77135
    LRR_8; Leucine rich repeat
    cl26018
    Location:324558
    NEL; C-terminal novel E3 ligase, LRR-interacting
    cl26793
    Location:40206
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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