TLR2 toll like receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TLR2provided by HGNC
Official Full Name: toll like receptor 2provided by HGNC
Primary source: HGNC:HGNC:11848
See related: Ensembl:ENSG00000137462 MIM:603028
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIL4; CD282
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Broad expression in appendix (RPKM 15.9), bone marrow (RPKM 12.6) and 18 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 4q31.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	4	NC_000004.12 (153684080..153710643)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (154605404..154627243)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

In summary, we have demonstrated that the C-terminal tail of HMGB1 negatively regulates the interaction with TLR2.
Title: Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain.
Left atrial platelet TLR-2 and TLR-4 expression and serum HMGB-1 levels were higher in persistent Atrial fibrillation(AF) patients compared to paroxysmal AF patients. In the patient group, left atrial expression of TLR-2, 4 and HMGB-1 were significantly higher than the peripheral expression levels.
Title: Platelet Toll-like receptor and its ligand HMGB-1 expression is increased in the left atrium of atrial fibrillation patients.
TLR2 protein has a role in introduction of IL-6, IL-8, and TNF-alpha cytokines into human amniotic epithelial cells by Ureaplasma urealyticum-derived lipid-associated membrane proteins
Title: Ureaplasma urealyticum-derived lipid-associated membrane proteins introduce IL-6, IL-8, and TNF-α cytokines into human amniotic epithelial cells via Toll-like receptor 2.
No significant association between TLR2 + 2477G/A polymorphism and bacterial meningitis risk were found under allele contrast, recessive genetic model.
Title: Association between TLR2 + 2477G/A polymorphism and bacterial meningitis: a meta-analysis.
The detection of higher frequencies of the TLR2, TLR4 and/or TLR9 polymorphisms in colorectal cancer (CRC) patients compared with the control groups highlight the role of these polymorphism in CRC development and cancer progression
Title: Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.
These findings further validated the involvement of P. acnes in the pathology of intervertebral disc degeneration (IVDD) and provided evidence that P. acnes-induced apoptosis of NPCs via the TLR2/JNK pathway is likely responsible for the pathology of IVDD.
Title: Propionibacterium acnes induces intervertebral disc degeneration by promoting nucleus pulposus cell apoptosis via the TLR2/JNK/mitochondrial-mediated pathway.
Live Faecalibacterium prausnitzii, an abundant obligate anaerobe of the colonic microbiota, induced higher TLR2 and TLR2/6 activation than the dead bacterium.
Title: Live Faecalibacterium prausnitzii induces greater TLR2 and TLR2/6 activation than the dead bacterium in an apical anaerobic co-culture system.
the results of the present study showed significantly higher mRNA expression levels for TLR2 180days post-transplantation in the graft dysfunction group compared to well functioning graft group
Title: Expression patterns of Toll like receptor (TLR)-2, TLR-4 and myeloid differentiation primary response gene 88 (MYD88) in renal transplant patients developing allograft dysfunction; a cohort study.
Finding suggest that genetic variation in TLR2 (rs3804099) is associated with severity and prognosis of bacterial meningitis in Chinese children.
Title: Polymorphisms of toll-like receptors 2 and 9 and severity and prognosis of bacterial meningitis in Chinese children.
The findings show that the expression of TLR2, TLR4 and TLR9, and hypoxia markers HIF-1alpha and CAIX is abnormal in pancreatic intraepithelial neoplasia suggesting that both the innate immunity activation and hypoxia response are involved in early pancreatic carcinogenesis.
Title: Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.

Submit: New GeneRIF Correction See all GeneRIFs (1157)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Leprosy 3 MedGen: C1968668 OMIM: 246300 GeneReviews: Not available	Compare labs
Mycobacterium tuberculosis, susceptibility to MedGen: C1834752 OMIM: 607948 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 replication is enhanced by TLR2; when neutralized with anti-TLR2 antibody HIV-1 (BAL) proviral DNA is decreased relative to non-specific antibody in TZM-bl-2 cells	PubMed
HIV-1 infection is enhanced by TLR2 stimulation via Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) in TZM-bl cells	PubMed
HIV-1 replication is enhanced by TLR2 stimulation or TNF treatment in Langerhans cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation	PubMed
	env	Treatment of HIV-1 gp120 to astroglia displays significant increases in TLR2	PubMed
Envelope transmembrane glycoprotein gp41	env	Fully processed HIV-1 Env protein, once expressed on the cellular membrane, inhibits TLR2 activation	PubMed
	env	HIV-1 gp41 binds TLR2 (from TZM-bl-2 cell lysates)	PubMed
	env	siRNA knockdown of TLR2 in a HIV-1 gp41-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production	PubMed
	env	Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 gp41 decreases IL-8 production	PubMed
	env	Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 gp41 increases the production of IL-8	PubMed
	env	The HIV-1 gp41 transmembrane domain (TMD) inhibits the interaction between the TMDs of TLR2 and TLR6 in vitro	PubMed
	env	The transmembrane domain (TMD) of HIV-1 gp41 directly interacts with the TLR2 TMD within the membrane, partially through its GxxxG dimerization motif	PubMed
	env	The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6	PubMed
	env	The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells	PubMed
Nef	nef	HIV-1 Nef-mediated upregulation of TLR2 increases regulatory T cells (Tregs) and inhibits the proliferation of PBMCs	PubMed
	nef	HIV-1 Nef upregulates TLR2 expression via NF-kappaB activation in THP-1 cells	PubMed
Tat	tat	Treatment of HIV-1 Tat to astroglia displays significant increases in TLR2 expression	PubMed
capsid	gag	HIV-1 CA binds TLR2 (from TZM-bl-2 cell lysates)	PubMed
	gag	Exposure of the TLR2 transgene cell line, HEK293-TLR2/6, to HIV-1 CA (p24) increases the production of IL-8 BUT NOT in the TLR2 transgene cell lines, TZM-bl-2 and HEK293-TLR2/1	PubMed
	gag	Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 CA (p24) decreases IL-8 production	PubMed
	gag	The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells	PubMed
matrix	gag	HIV-1 MA (p17) binds TLR2 (from TZM-bl-2 cell lysates)	PubMed
	gag	siRNA knockdown of TLR2 in a HIV-1 MA (p17)-exposed TLR2 transgene cell line, TZM-bl-2, decreases IL-8 production	PubMed
	gag	Exposure of anti-TLR2 antibody-treated primary T cells to HIV-1 MA (p17) decreases IL-8 production	PubMed
	gag	Exposure of TLR2 transgene cell lines (TZM-bl-2, HEK293-TLR2/1, HEK293-TLR2/6) to HIV-1 MA (p17) increases the production of IL-8	PubMed
	gag	The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
Antimicrobial peptides, organism-specific biosystem (from REACTOME)
Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
Beta defensins, organism-specific biosystem (from REACTOME)
Beta defensins, organism-specific biosystemHumans have 38 beta-defensin genes plus 9-10 pseudogenes (details available on the HGNC website at http://www.genenames.org/genefamilies/DEFB). Many beta-defensins are encoded by recently duplicated ...
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
Defensins, organism-specific biosystem (from REACTOME)
Defensins, organism-specific biosystemThe defensins are a family of antimicrobial cationic peptide molecules which in mammals have a characteristic beta-sheet-rich fold and framework of six disulphide-linked cysteines (Selsted & Ouellet...
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
Diseases associated with the TLR signaling cascade, organism-specific biosystem (from REACTOME)
Diseases associated with the TLR signaling cascade, organism-specific biosystemToll like receptors (TLRs) are sensors of the innate immune system that detect danger signals derived from pathogens (pathogen-associated molecular patterns - PAMP) or damaged cells (damage-associate...
Diseases of Immune System, organism-specific biosystem (from REACTOME)
Diseases of Immune System, organism-specific biosystemThe immune system is a complex network of the biological processes that provide defense mechanisms during infection or in response to an intrinsic danger signal. Compromised immune response may prese...
ER-Phagosome pathway, organism-specific biosystem (from REACTOME)
ER-Phagosome pathway, organism-specific biosystemThe other TAP-dependent cross-presentation mechanism in phagocytes is the endoplasmic reticulum (ER)-phagosome model. Desjardins proposed that ER is recruited to the cell surface, where it fuses wit...
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
IL1 and megakaryocytes in obesity, organism-specific biosystem (from WikiPathways)
IL1 and megakaryocytes in obesity, organism-specific biosystemSchematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory a...
IRAK4 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
IRAK4 deficiency (TLR2/4), organism-specific biosystemInterleukin-1 receptor-associated kinase 4 (IRAK4) is a serine/threonine kinase, that mediates activation of transcriptional factors such as NFkB and AP1 downstream of IL-1 receptors and all toll lik...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Leishmaniasis, organism-specific biosystem (from KEGG)
Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Leishmaniasis, conserved biosystem (from KEGG)
Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
Malaria, organism-specific biosystem (from KEGG)
Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Malaria, conserved biosystem (from KEGG)
Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
MyD88 deficiency (TLR2/4), organism-specific biosystem (from REACTOME)
MyD88 deficiency (TLR2/4), organism-specific biosystemMyeloid differentiation primary response (MyD88) is an adaptor protein that mediates intracellular signaling pathways evoked by all Toll-like receptors (TLRs) except for TLR3 and by several interleuk...
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of TLR by endogenous ligand, organism-specific biosystem (from REACTOME)
Regulation of TLR by endogenous ligand, organism-specific biosystemDiverse molecules of host-cell origin may serve as endogenous ligands of Toll-like receptors (TLRs) (Erridge C 2010; Piccinini AM & Midwood KS 2010). These molecules are known as damage-associated mo...
Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Regulation of toll-like receptor signaling pathway, organism-specific biosystem
Regulation of toll-like receptor signaling pathway
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystem (from WikiPathways)
Simplified Depiction of MYD88 Distinct Input-Output Pathway, organism-specific biosystemThis pathway is based on figure 7 from Li et al. Formation of MyD88 dimer catalyzes formation of IRAK1/TRAF6 complex. UEV1A and Ubc13 ubiquinate TRAF6 which allow for the activation of NFKB and AP-1 ...
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
Toll-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
Toll-like Receptor Signaling, organism-specific biosystemThis pathway is based on the figure 1 of "Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study" (see bibliography). TLR and NFkB are important in inflamma...
Toll-like Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Toll-like Receptor Signaling Pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling, organism-specific biosystem (from KEGG)
Toll-like receptor signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
Toll-like receptor signaling, conserved biosystem (from KEGG)
Toll-like receptor signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC98129P1 (e-PCR)
- UniSTS:273665

PMC98226P1 (e-PCR)
- UniSTS:273667

PMC98510P1 (e-PCR)
- UniSTS:273671

PMC201071P1 (e-PCR)
- UniSTS:271880

D4S660 (e-PCR)
- UniSTS:95274

D4S841 (e-PCR)
- UniSTS:32812

TLR2 (e-PCR)
- UniSTS:503343

D4S575 (e-PCR)
- UniSTS:35904

G34296 (e-PCR)
- UniSTS:1092

SHGC4-1535 (e-PCR)
- UniSTS:51781

TLR2_1084.2 (e-PCR)
- UniSTS:466509

SHGC-33147 (e-PCR)
- UniSTS:62605

PMC37511P1 (e-PCR)
- UniSTS:273305

TLR2 (e-PCR)
- UniSTS:277943

AF368419 (e-PCR)
- UniSTS:277943

PMC55404P2 (e-PCR)
- UniSTS:273341

PMC128073P3 (e-PCR)
- UniSTS:270565

PMC97725P1 (e-PCR)
- UniSTS:273658

Homology

Homologs of the TLR2 gene: The TLR2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 187 organisms have orthologs with human gene TLR2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
Toll-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
amyloid-beta binding	ISS Inferred from Sequence or Structural Similarity more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
lipopolysaccharide receptor activity	TAS Traceable Author Statement more info	PubMed
peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
signaling pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
signaling receptor activity	TAS Traceable Author Statement more info	PubMed
triacyl lipopeptide binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
I-kappaB phosphorylation	IDA Inferred from Direct Assay more info	PubMed
MyD88-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
apoptotic process	TAS Traceable Author Statement more info	PubMed
cell activation	IDA Inferred from Direct Assay more info	PubMed
cellular response to bacterial lipopeptide	TAS Traceable Author Statement more info	PubMed
cellular response to diacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
cellular response to interferon-gamma	IDA Inferred from Direct Assay more info	PubMed
cellular response to lipoteichoic acid	IDA Inferred from Direct Assay more info	PubMed
cellular response to lipoteichoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to triacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
central nervous system myelin formation	IEA Inferred from Electronic Annotation more info
cytokine secretion involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
detection of diacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
detection of triacyl bacterial lipopeptide	IDA Inferred from Direct Assay more info	PubMed
immune response	TAS Traceable Author Statement more info	PubMed
inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
innate immune response	TAS Traceable Author Statement more info	PubMed
interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
learning	ISS Inferred from Sequence or Structural Similarity more info
leukotriene metabolic process	IEA Inferred from Electronic Annotation more info
lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
microglia development	ISS Inferred from Sequence or Structural Similarity more info
microglial cell activation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
neutrophil degranulation	TAS Traceable Author Statement more info
nitric oxide metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NIK/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cellular response to macrophage colony-stimulating factor stimulus	IDA Inferred from Direct Assay more info	PubMed
positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of inflammatory response	IC Inferred by Curator more info	PubMed
positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
positive regulation of interleukin-12 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-18 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-8 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-8 secretion	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of nitric-oxide synthase biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
response to fatty acid	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to insulin	IEA Inferred from Electronic Annotation more info
response to progesterone	IEA Inferred from Electronic Annotation more info
response to toxic substance	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed
toll-like receptor 2 signaling pathway	IEA Inferred from Electronic Annotation more info
toll-like receptor TLR1:TLR2 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor TLR6:TLR2 signaling pathway	TAS Traceable Author Statement more info
toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
toll-like receptor signaling pathway	TAS Traceable Author Statement more info
tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
Toll-like receptor 1-Toll-like receptor 2 protein complex	IDA Inferred from Direct Assay more info	PubMed
cell body	IEA Inferred from Electronic Annotation more info
cell projection	IEA Inferred from Electronic Annotation more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intrinsic component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intrinsic component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
membrane raft	IDA Inferred from Direct Assay more info	PubMed
phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
secretory granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: toll-like receptor 2

Names: toll/interleukin-1 receptor-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016229.1 RefSeqGene

Range

4964..26972

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001318787.1 → NP_001305716.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424049, AK125659, AW614989, BC033756, BQ017238, CB528396, DA582193

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Related

ENSP00000260010.6, ENST00000260010.6

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318789.1 → NP_001305718.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Related

ENSP00000494425.1, ENST00000642700.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318790.1 → NP_001305719.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA870971

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318791.1 → NP_001305720.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424052, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318793.1 → NP_001305722.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424051, AK125659, AW614989, BC033756, BQ017238, CB528396, DA460298

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318795.1 → NP_001305724.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424053, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_001318796.1 → NP_001305725.1 toll-like receptor 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424049, AK125659, AW614989, BC033756, BQ017238, CB528396

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4, B3KWR9

Related

ENSP00000495339.1, ENST00000642580.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_003264.4 → NP_003255.2 toll-like receptor 2 precursor

See identical proteins and their annotated locations for NP_003255.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-8 all encode the same protein.

Source sequence(s)

AF424049, AI493140, AW614989, BC033756, BQ017238, DQ012267

Consensus CDS

CCDS3784.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p12 Primary Assembly

Range

153684080..153710643

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017008573.1 → XP_016864062.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_017008574.1 → XP_016864063.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_017008575.1 → XP_016864064.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_011532215.2 → XP_011530517.1 toll-like receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011530517.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_011532216.2 → XP_011530518.1 toll-like receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011530518.1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
XM_017008576.1 → XP_016864065.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

O60603

UniProtKB/TrEMBL

A0A0S2Z4S4

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

sd00033
Location:54 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl26018
Location:324 → 558

NEL; C-terminal novel E3 ligase, LRR-interacting

cl26793
Location:40 → 206

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional