Format

Send to:

Choose Destination

SGK3 serum/glucocorticoid regulated kinase family member 3 [ Homo sapiens (human) ]

Gene ID: 23678, updated on 9-Sep-2018

Summary

Official Symbol
SGK3provided by HGNC
Official Full Name
serum/glucocorticoid regulated kinase family member 3provided by HGNC
Primary source
HGNC:HGNC:10812
See related
Ensembl:ENSG00000104205 MIM:607591; Vega:OTTHUMG00000164561
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CISK; SGK2; SGKL
Summary
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.0), kidney (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See SGK3 in Genome Data Viewer
Location:
8q13.1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (66712418..66862022)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67624653..67774257)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene valosin containing protein interacting protein 1 Neighboring gene C8orf44-SGK3 readthrough Neighboring gene chromosome 8 open reading frame 44 Neighboring gene pituitary tumor-transforming 3, pseudogene Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6 Neighboring gene transcription factor 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough C8orf44-SGK3

Readthrough gene: C8orf44-SGK3, Included gene: C8orf44

Homology

Clone Names

  • DKFZp781N0293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
chloride channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Sgk3
Names
cytokine-independent survival kinase
NP_001028750.1
NP_037389.4
NP_733827.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050857.1 RefSeqGene

    Range
    5001..154605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033578.2NP_001028750.1  serine/threonine-protein kinase Sgk3 isoform 1

    See identical proteins and their annotated locations for NP_001028750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AI127772, AK291428, BQ777590, BU177012, CK822899, CR933673
    Consensus CDS
    CCDS6195.1
    UniProtKB/Swiss-Prot
    Q96BR1
    UniProtKB/TrEMBL
    A0A024R807, Q5H9Q5
    Related
    ENSP00000430463.1, OTTHUMP00000226963, ENST00000521198.6, OTTHUMT00000379232
    Conserved Domains (2) summary
    cd06870
    Location:12120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3
  2. NM_013257.4NP_037389.4  serine/threonine-protein kinase Sgk3 isoform 1

    See identical proteins and their annotated locations for NP_037389.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AI127772, AK223523, AK291428, BQ777590, BU177012, CK822899, CR933673, DB447859
    Consensus CDS
    CCDS6195.1
    UniProtKB/Swiss-Prot
    Q96BR1
    UniProtKB/TrEMBL
    A0A024R807, Q53EW6, Q5H9Q5
    Related
    ENSP00000379842.1, ENST00000396596.2
    Conserved Domains (2) summary
    cd06870
    Location:12120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3
  3. NM_170709.2NP_733827.2  serine/threonine-protein kinase Sgk3 isoform 2

    See identical proteins and their annotated locations for NP_733827.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI127772, AK074666, AK223523, BQ777590, BU177012, CK822899, CR933673, DB447859
    Consensus CDS
    CCDS6196.1
    UniProtKB/Swiss-Prot
    Q96BR1
    UniProtKB/TrEMBL
    Q53EW6, Q5H9Q5
    Related
    ENSP00000430691.1, OTTHUMP00000226966, ENST00000520976.5, OTTHUMT00000379236
    Conserved Domains (3) summary
    cd06870
    Location:12120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    smart00220
    Location:162387
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:165458
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    66712418..66862022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center