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C8orf44-SGK3 C8orf44-SGK3 readthrough [ Homo sapiens (human) ]

Gene ID: 100533105, updated on 22-May-2022

Summary

Official Symbol
C8orf44-SGK3provided by HGNC
Official Full Name
C8orf44-SGK3 readthroughprovided by HGNC
Primary source
HGNC:HGNC:48354
See related
Ensembl:ENSG00000288602 AllianceGenome:HGNC:48354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This locus represents naturally occurring read-through transcription between the neighboring putative uncharacterized protein C8orf44 (GeneID 56260) and serine/threonine-protein kinase Sgk3 (GeneID 23678) genes on chromosome 8. The read-through transcript produces a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in thyroid (RPKM 9.3), kidney (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See C8orf44-SGK3 in Genome Data Viewer
Location:
8q13.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (66667596..66862022)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (67093351..67288509)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (67579831..67774257)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375884 Neighboring gene valosin containing protein interacting protein 1 Neighboring gene chromosome 8 open reading frame 44 Neighboring gene serum/glucocorticoid regulated kinase family member 3 Neighboring gene pituitary tumor-transforming 3, pseudogene Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87 Neighboring gene small nucleolar RNA host gene 6 Neighboring gene transcription factor 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • DKFZp779G0825

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables chloride channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Sgk3
Names
cytokine-independent survival kinase
serum/glucocorticoid-regulated kinase 3
NP_001191102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204173.2NP_001191102.1  serine/threonine-protein kinase Sgk3

    See identical proteins and their annotated locations for NP_001191102.1

    Status: VALIDATED

    Source sequence(s)
    AC011031, AC090154, BX649057
    UniProtKB/Swiss-Prot
    Q96BR1
    UniProtKB/TrEMBL
    A0A024R807
    Related
    ENSP00000429022.1, ENST00000519289.1
    Conserved Domains (2) summary
    cd06870
    Location:12120
    PX_CISK; The phosphoinositide binding Phox Homology Domain of Cytokine-Independent Survival Kinase
    cd05604
    Location:165490
    STKc_SGK3; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    66667596..66862022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    67093351..67288509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)