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CDK20 cyclin dependent kinase 20 [ Homo sapiens (human) ]

Gene ID: 23552, updated on 20-Mar-2020

Summary

Official Symbol
CDK20provided by HGNC
Official Full Name
cyclin dependent kinase 20provided by HGNC
Primary source
HGNC:HGNC:21420
See related
Ensembl:ENSG00000156345 MIM:610076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P42; CCRK; CDCH; PNQALRE
Summary
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
Expression
Broad expression in testis (RPKM 10.2), adrenal (RPKM 7.6) and 24 other tissues See more
Orthologs

Genomic context

See CDK20 in Genome Data Viewer
Location:
9q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (87966441..87974780, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90581356..90589695, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC497256 Neighboring gene SPATA31 subfamily C member 1 Neighboring gene zinc finger protein 598, E3 ubiquitin ligase pseudogene Neighboring gene uncharacterized LOC105376131 Neighboring gene RNA, U6 small nuclear 86, pseudogene Neighboring gene ribosomal protein S10 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 20
Names
CAK-kinase p42
CDK-activating kinase p42
cell cycle-related kinase
cell division protein kinase 20
cyclin-dependent protein kinase H
cyclin-kinase-activating kinase p42
NP_001034892.1
NP_001164110.1
NP_001164111.1
NP_036251.2
NP_848519.1
XP_016870050.1
XP_016870051.1
XP_016870052.1
XP_016870053.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039803.3NP_001034892.1  cyclin-dependent kinase 20 isoform 3

    See identical proteins and their annotated locations for NP_001034892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and contains an alternate, in-frame exon in the middle portion of the coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI479563, AL353572, BM982394
    Consensus CDS
    CCDS35060.1
    UniProtKB/Swiss-Prot
    Q8IZL9
    Related
    ENSP00000322343.8, ENST00000325303.8
    Conserved Domains (2) summary
    PLN00009
    Location:1288
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3289
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
  2. NM_001170639.2NP_001164110.1  cyclin-dependent kinase 20 isoform 4

    See identical proteins and their annotated locations for NP_001164110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, and an alternate splice site in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BC002655, BM982394, CB992644
    Consensus CDS
    CCDS65075.1
    UniProtKB/Swiss-Prot
    Q8IZL9
    UniProtKB/TrEMBL
    A0A0S2Z5B6
    Related
    ENSP00000474485.1, ENST00000605159.5
    Conserved Domains (1) summary
    cd07832
    Location:3273
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
  3. NM_001170640.1NP_001164111.1  cyclin-dependent kinase 20 isoform 5

    See identical proteins and their annotated locations for NP_001164111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, and lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform 5, also known as cardiac CCRK), compared to isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BM982394, CB992644, DB469301
    Consensus CDS
    CCDS55324.1
    UniProtKB/Swiss-Prot
    Q8IZL9
    Related
    ENSP00000365031.3, ENST00000375871.8
    Conserved Domains (2) summary
    smart00220
    Location:4167
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:3167
    PKc_like; Protein Kinases, catalytic domain
  4. NM_012119.4NP_036251.2  cyclin-dependent kinase 20 isoform 2

    See identical proteins and their annotated locations for NP_036251.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BM982394, CB992644, DB469301
    Consensus CDS
    CCDS6677.1
    UniProtKB/Swiss-Prot
    Q8IZL9
    Related
    ENSP00000365043.3, ENST00000375883.7
    Conserved Domains (2) summary
    PLN00009
    Location:1267
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3268
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
  5. NM_178432.3NP_848519.1  cyclin-dependent kinase 20 isoform 1

    See identical proteins and their annotated locations for NP_848519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI479563, AK075325, AL353572, AY904367, BM982394, CB992644, DB469301
    Consensus CDS
    CCDS6678.1
    UniProtKB/Swiss-Prot
    Q8IZL9
    Related
    ENSP00000338975.5, ENST00000336654.9
    Conserved Domains (2) summary
    PLN00009
    Location:1280
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3281
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    87966441..87974780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014564.2XP_016870053.1  cyclin-dependent kinase 20 isoform X4

    UniProtKB/TrEMBL
    A0A0S2Z562
    Conserved Domains (2) summary
    PLN00009
    Location:1259
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07832
    Location:3260
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
  2. XM_017014563.2XP_016870052.1  cyclin-dependent kinase 20 isoform X3

  3. XM_017014561.2XP_016870050.1  cyclin-dependent kinase 20 isoform X1

    Related
    ENST00000486228.7
  4. XM_017014562.2XP_016870051.1  cyclin-dependent kinase 20 isoform X2

RNA

  1. XR_001746264.2 RNA Sequence

  2. XR_001746265.2 RNA Sequence

  3. XR_001746263.2 RNA Sequence

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