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Cdk20 cyclin dependent kinase 20 [ Mus musculus (house mouse) ]

Gene ID: 105278, updated on 12-May-2024

Summary

Official Symbol
Cdk20provided by MGI
Official Full Name
cyclin dependent kinase 20provided by MGI
Primary source
MGI:MGI:2145349
See related
Ensembl:ENSMUSG00000021483 AllianceGenome:MGI:2145349
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p42; CDCH; Ccrk; PNQLARE; 4932702G04Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including chordate embryonic development; embryonic organ development; and negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in thymus primordium. Orthologous to human CDK20 (cyclin dependent kinase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 18.6), testis adult (RPKM 12.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cdk20 in Genome Data Viewer
Location:
13 B3; 13 33.26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64580133..64587536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64432319..64439722)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31128 Neighboring gene STARR-positive B cell enhancer ABC_E3084 Neighboring gene cathepsin L Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:64509468-64509621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:64511983-64512222 Neighboring gene RIKEN cDNA 1700015C15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:64533677-64533786 Neighboring gene predicted gene, 31218 Neighboring gene BTB (POZ) domain containing 3 pseudogene Neighboring gene family with sequence similarity 240 member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Clone Names

  • MGC38901

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within floor plate formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of protein maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 20
Names
CAK-kinase p42
CDK-activating kinase p42
CDK-related protein kinase PNQLARE
cell cycle-related kinase
cell division protein kinase 20
cyclin-dependent protein kinase H
cyclin-kinase-activating kinase p42
NP_444410.1
XP_030102968.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053180.2NP_444410.1  cyclin-dependent kinase 20

    See identical proteins and their annotated locations for NP_444410.1

    Status: PROVISIONAL

    Source sequence(s)
    BC031907
    Consensus CDS
    CCDS26601.1
    UniProtKB/Swiss-Prot
    Q5EDC2, Q9JHU3
    UniProtKB/TrEMBL
    A0A1Y7VNS6
    Related
    ENSMUSP00000021939.7, ENSMUST00000021939.8
    Conserved Domains (1) summary
    cd07832
    Location:3289
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64580133..64587536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247108.2XP_030102968.1  cyclin-dependent kinase 20 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VNS6
    Conserved Domains (1) summary
    cd07832
    Location:3251
    STKc_CCRK; Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase

RNA

  1. XR_001780742.1 RNA Sequence

  2. XR_001780741.1 RNA Sequence

  3. XR_001780743.1 RNA Sequence

  4. XR_003950406.2 RNA Sequence