Conserved Protein Domain Family
STKc_CCRK

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cd07832: STKc_CCRK 
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270826
View PSSM: cd07832
Aligned: 13 rows
Threshold Bit Score: 434.064
Threshold Setting Gi: 86438640
Created: 24-Sep-2008
Updated: 2-Mar-2014
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:includes ATP binding and substrate binding sites
  • Comment:based on the structures of human CDK2 and DYRK1A bound with ATP or inhibitor and substrate peptides, and on the structures of other CMGC kinases, bound with ATP or ATP analogs
  • Citation:PMID 9739089

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1               #####   #              # #                #                  #           
Q8IZL9         3 QYCILGRIGEGAHGIVFKAKHVET--GEIVALKKVALRRleDGFPNQALREIKALQEMe----dNQYVVQLKAVFPh--- 73  human
XP_001641928   6 QYTILGRIGEGAHGIVFKAKHIES--GEIVALKKVPLRRleDGIPNTALREIKSLQENe----eNPYVVKLIDVFPh--- 76  starlet sea ane...
XP_799108     11 QYSILDRIGEGAHGIVFKAKHIET--GEIVALKKVPLRKldDGIPNTALREIKALQEIe----eNQYVVKLKDVFPh--- 81  purple urchin
XP_002119796   3 QYHILGRIGEGAHGIVFKAKHIER--GEVVALKKVPLRKieDGIPNQALREIKALQEIggdsedAQNVVKLHDVFPh--- 77  Ciona intestinalis
XP_001606120   3 RYTISGRIGEGAHGLVLKAYDNASpvPKPVALKRILLKRieDGIPTSVVREVKTLQRLk-----HPYIVELLDAFPa--- 74  jewel wasp
CAP19557       3 QYSILGRIGEGAHGIVFKAKHIET--GETVALKKVALRRleDGIPNQALREIKALQEIe----dNQYVVKLKDVFPh--- 73  zebrafish
AAI06519       3 QYSLLGRIGEGAHGIVFKAKHIET--GEVVALKKVALRKleEGIPNQALREIKALREIe----dNPHVVKLRDVFPh--- 73  African clawed ...
XP_966910      3 NYKLLGKVGKGAHGLVFKALDLQN--NKTVALKQIAVVNvtNGIPKNTMREICVLRALq-----SKHIVKLVDIFNv--- 72  red flour beetle
NP_650984      8 RYKMLEKIGEGVHGCVFKAIDLQR--NKEVAIKKVALKNkfGNIALNTLREIKTLQLCk-----SEYILDIIDIYPd--- 77  fruit fly
XP_001850208   8 RYQMLGRIGEGVHGVVVKARDLSNd-DKIVAIKKLTLRTkhGWIAPCAIREIKVLQNSq-----CENILSLLDMYPd--- 78  southern house ...
XP_002427364   6 EYKVIGRIGEGAHGIVLKAKNRKT--GKLVALKRMLNNKgnEKVQLSLLREIESLKHVn-----STYVIKLLEVLTv--- 75  human body louse
ABA97935       3 RYECLGKIGEGAAGVVHVARDRTT--GETVAVKRLHGGI--GCGEEEWLREARCLQACr----gHPHLVELRAAHRemrr 74  Japanese rice
CAJ26356      37 DCEETGALGEGAFGAVVEARHRAT--GEAVAIKKACSPTrnGGTGTGMMREAAFLAACq----gHGNVVELRAVSLeplg 110 Brachypodium sy...
Feature 1                  ####   # ##                                      # # ## #             
Q8IZL9        74 ---gGGFVLAFEFML-SDLAEVVRHaq--rpLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISa-----sGQLK 142 human
XP_001641928  77 ---gTGFVLVFEYMW-SDLSEVLRNse--rpLTEAQIKGYLLMLLKGVAYCHNKGIMHRDLKPANLLISs-----tGHLK 145 starlet sea ane...
XP_799108     82 ---gTGFVLVFEFML-SDLSEVIRNsd--qpLTEAQVKSYMLMLLKGITHCHENSIMHRDLKPANLLISe-----tGHLK 150 purple urchin
XP_002119796  78 ---gTGFVLVFEYML-SDLSEVIRNse--rsLTESQIKSYMMMLLKGVAFCHQNNIMHRDLKPANLLISs-----tGHLK 146 Ciona intestinalis
XP_001606120  75 ---gLDFVMVFEYMP-SGLWELLKDyd--kaLTDSQIKTYTRMLLEGVAYMHANNIMHRDLKPANLLIRe-----dGVLT 143 jewel wasp
CAP19557      74 ---gTGFVLVFEYML-SDLSEVIRNsq--rpLTASQVKSYMMMLLKGVAFCHENSIMHRDLKPANLLISs-----tGHLK 142 zebrafish
AAI06519      74 ---gTGFVLVFEYML-SDLSEVIRNse--qpLTEAQVKGYMIMLLKGVRFCHDNAIMHRDLKPANLLISs-----tGQLK 142 African clawed ...
XP_966910     73 ---dSSIIIAMEYLQ-RSLSDVLKDie--rpLTTPQIKLYTKMILMGVETMHSNRIMHRDLKPANLLIDd-----hGVLK 141 red flour beetle
NP_650984     78 ---lTGLSLVLEYQP-DTLYNRLKSev--npLSRQQVRKFAHQMFKGIAYLHEAGLMHRDIKPANLLISd-----tDMLK 146 fruit fly
XP_001850208  79 ---lSGMSLVFEYMP-HTLYSRMKDee--hpLSRGETRRFMAMLLNGLQYLHGLRIMHRDIKPANLLIDs-----kDVLK 147 southern house ...
XP_002427364  76 ---gSSVVLVLELMA-GGLSSVIGDvd--dpIQIPQVKAYSRMILEGCSHLHKLKIMHRDLKPANLLIGf-----dGILK 144 human body louse
ABA97935      75 ggggACCYVVMEYVDgPSLSRVVREerrgrpFPEAEARRLMRQLLDGVAAMHAAGVMHRDLKPDNVVVGp-----rGDLK 149 Japanese rice
CAJ26356     111 -sspERLSLVMGLVG-PSLHDVLHHrrggrpFPEAEVRCIMRQLLAGAQHMHGLRVVHRDIKPQNILVVagdgdqiESVK 188 Brachypodium sy...
Feature 1          #  #             # #### #                                     #               
Q8IZL9       143 IADFGLARVFSPDgs-rlYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNgSPLFPGknDIEQLCYVLRILG 221 human
XP_001641928 146 IADFGLARVFSNEge-rqYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNnSPLFPGenDIEQLCCVLKTLG 224 starlet sea ane...
XP_799108    151 IADFGLARVFSNDeg-rqYSHQVATRWYRAPELLYGARKYDEGADLWAVGCIFGELLNnSPIFPGenDIEQLCCVLRILG 229 purple urchin
XP_002119796 147 IADFGLARVFDNDae-rlYSHQVATRWYRSPELLYGARRYDEGVDLWAVGCIFGEMLNnSPLFPGenDIEQLCCVLRVLG 225 Ciona intestinalis
XP_001606120 144 IADFGLGRLMWEDis-rpYSHQVATRWYRAPELLYGARFYTAAIDMWAVGCIFGEMLNnSPLFPGesDIEQLAIVLGHLG 222 jewel wasp
CAP19557     143 IADFGLARLFSNEgd-rlYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNnSPLFPGenDIEQLCCVLRVLG 221 zebrafish
AAI06519     143 IADFGLARVFSSErg-rlYSHQVATRWYRAPELLYGARKYDEGVDLWAVGCIFGELLNgSPLFPGenDIEQLCCVLRTLG 221 African clawed ...
XP_966910    142 IADFGLSRIYNKEkd-rqYTHQVGTRWYRAPELLYGSQKYTPAVDIWAVGCILAEMINkQPLFPGetDIAQLAIVIATLG 220 red flour beetle
NP_650984    147 IADFGLARLYFPEdesrlYSPQVSTRWYRAPEILFGSQKYGTGVDMWAAGCVVAEMLRgVPLFAGttDIEQLAIIIRTLG 226 fruit fly
XP_001850208 148 IADFGLARLFNDQdptkvYSPQVATRWYRAPEILWGCQTYGPSIDLWAAGCVFAEMLRgVPLFSGatDIEQLALVVRTLG 227 southern house ...
XP_002427364 145 IADLGQARLNKGRp----YSHQIGSRWYRAPELLYGSRKYSLSIDVWSIGCIIAEMINcSPLFAGesDIEQLAIVIKSLG 220 human body louse
ABA97935     150 ICDFGMSRVTAAGap--pYTSPVVTLWYRAPELILGSQEYDSLVDTWSLGCIMAELLAgAPLFPGrsEMDQLNRVFDTVG 227 Japanese rice
CAJ26356     189 ICDLGLAVSMSEPt----PYERCGTRRYMAPEVLLGKPDYDAAVDAWSLGCVMAELLAgAPLFDGedDGAQLLSIFSVLG 264 Brachypodium sy...
Feature 1                                                                                 
Q8IZL9       222 TPNPqVWPELTELPdy-nKISFKEQVPMP--LEEVLPDVS--PQALDLLGQFLLYPPHQRIAaSKALLHQYFF 289 human
XP_001641928 225 TPNEeIWPGMTDLPdy-nKITFPDMPAIP--LEKIVPDAS--PEAMDLLKRFLVYPSKKRIPaSEALLHPYFF 292 starlet sea anemone
XP_799108    230 TPTEkTWPGMKDLPdy-nKITFPENPPIP--LEQIVPDAS--PEALDLLKKFLVYPSRQRISaSEALLHPYFF 297 purple urchin
XP_002119796 226 TPNEtIWPGMSILPdy-nKITFPENPPIP--LEEIVPDAS--EDALDLLKKFLVYPSNQRIAaTHALLHPYFF 293 Ciona intestinalis
XP_001606120 223 SPTAeSWPELSSLPdy-nKITFPYHKGVL--WERIVPDAQ--QEAVDLLRNILIYDSSKRLTaEEALRHVYFN 290 jewel wasp
CAP19557     222 TPNQkVWPEITELPdy-nKITFKENPPIP--LEEIVPDTS--PQAVDLLKKFLVYPSKQRISaRQALLHPYFF 289 zebrafish
AAI06519     222 TPNPkTWPEITDLPdy-nKISFKEHRPLP--PERIVPDTS--PEALHLLMRFLVYPSNLRIRaAEALLHPYFF 289 African clawed frog
XP_966910    221 TPNEeIWPGLTSLPdy-nKIAFTHSDGQT--WNSKFPDCD--EATVDLIQQFLHYDQSKRIGaKKALNHRFFF 288 red flour beetle
NP_650984    227 SPRLnQWPELTSLPdy-sKIRFPNSVGIH--WDNLFPSCTh-AVEINLVSNLVVYNPKNRLKaSEVGSASSLT 295 fruit fly
XP_001850208 228 TPNLkDWPEVRSLPdy-nKIRFPNAKGER--WEDIFPSCTt-KCEIGLVDGLVRYNPSRRFTaEELLKMRRKY 296 southern house mosquito
XP_002427364 221 SPSEeTWPGVHTLPdy-gKITFPKSKGKL--WKTLIPNSP--PGAIDLLKSLLLYNPKERLScEQALNHSFFY 288 human body louse
ABA97935     228 MQDMkSWPGFARLPraesALCSRARPPSR--LREMFPKLS--AAGFDVLSGLLACRPDRRLTaADALRCAWFT 296 Japanese rice
CAJ26356     265 VPLFtLWPEYKSLPla-gKVVQPPNKRHRnkLRQHFPEERlsEEGFEVLQGLLSCNIDKRLSaTTTLRRPWFT 336 Brachypodium sylvaticum

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