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MACF1 microtubule-actin crosslinking factor 1 [ Homo sapiens (human) ]

Gene ID: 23499, updated on 9-Sep-2018

Summary

Official Symbol
MACF1provided by HGNC
Official Full Name
microtubule-actin crosslinking factor 1provided by HGNC
Primary source
HGNC:HGNC:13664
See related
Ensembl:ENSG00000127603 MIM:608271; Vega:OTTHUMG00000007754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACF7; MACF; OFC4; ABP620
Summary
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in lung (RPKM 17.3), ovary (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See MACF1 in Genome Data Viewer
Location:
1p34.3
Exon count:
111
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (39084167..39487138)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (39549839..39952810)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene akirin 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene RNA, U6 small nuclear 608, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 44 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 8 Neighboring gene KIAA0754 Neighboring gene mitogen-activated protein kinase 7-like Neighboring gene transfer RNA-Lys (CTT) 12-1 Neighboring gene bone morphogenetic protein 8a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45612, FLJ46776, KIAA0465, KIAA1251

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA binding HDA PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
actin filament binding NAS
Non-traceable Author Statement
more info
PubMed 
cadherin binding HDA PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
microtubule minus-end binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Golgi to plasma membrane protein transport IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intermediate filament cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of focal adhesion assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-actin cross-linking factor 1
Names
620 kDa actin binding protein
actin cross-linking family protein 7
macrophin 1 isoform
trabeculin-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050926.1 RefSeqGene

    Range
    7751..410722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012090.5NP_036222.3  microtubule-actin cross-linking factor 1

    See identical proteins and their annotated locations for NP_036222.3

    Status: REVIEWED

    Source sequence(s)
    AB007934, AB029290, AF317696, AK127519, AL442071, DA512687, DR423112
    Consensus CDS
    CCDS435.1
    UniProtKB/Swiss-Prot
    Q9UPN3
    UniProtKB/TrEMBL
    Q6ZSD7
    Related
    ENSP00000354573.2, OTTHUMP00000009301, ENST00000361689.6, OTTHUMT00000020986
    Conserved Domains (8) summary
    smart00243
    Location:51625234
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:49295053
    SPEC; Spectrin repeats
    cd00014
    Location:79181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:50875149
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:42674483
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam05956
    Location:52515428
    APC_basic; APC basic domain
    pfam13499
    Location:50885148
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:20462253
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    39084167..39487138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710526.3XP_006710589.1  microtubule-actin cross-linking factor 1 isoform X14

    Related
    ENSP00000455823.1, OTTHUMP00000250401, ENST00000567887.5, OTTHUMT00000423088
    Conserved Domains (8) summary
    smart00150
    Location:70287152
    SPEC; Spectrin repeats
    cd00014
    Location:227330
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71867248
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63666582
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:18011841
    Plectin; Plectin repeat
    pfam02187
    Location:72647337
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71877247
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:51605375
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. XM_017000875.1XP_016856364.1  microtubule-actin cross-linking factor 1 isoform X13

    Related
    OTTHUMP00000234541, OTTHUMT00000392096
    Conserved Domains (8) summary
    smart00150
    Location:69967120
    SPEC; Spectrin repeats
    cd00014
    Location:79181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71547216
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63346550
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17691809
    Plectin; Plectin repeat
    pfam02187
    Location:72327305
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71557215
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:51285343
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_024446114.1XP_024301882.1  microtubule-actin cross-linking factor 1 isoform X27

    Related
    ENSP00000362006.3, ENST00000372915.7
    Conserved Domains (9) summary
    smart00243
    Location:72267304
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:69937117
    SPEC; Spectrin repeats
    COG5069
    Location:73297
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:63316547
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17691809
    Plectin; Plectin repeat
    pfam05956
    Location:73217498
    APC_basic; APC basic domain
    pfam13499
    Location:71497212
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:11641343
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl25732
    Location:41925030
    SMC_N; RecF/RecN/SMC N terminal domain
  4. XM_017000881.1XP_016856370.1  microtubule-actin cross-linking factor 1 isoform X25

  5. XM_024446116.1XP_024301884.1  microtubule-actin cross-linking factor 1 isoform X28

    Conserved Domains (8) summary
    smart00243
    Location:51595237
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:49265050
    SPEC; Spectrin repeats
    COG5069
    Location:73297
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00176
    Location:42644480
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam05956
    Location:52545431
    APC_basic; APC basic domain
    pfam13499
    Location:50825145
    EF-hand_7; EF-hand domain pair
    cl25732
    Location:21252963
    SMC_N; RecF/RecN/SMC N terminal domain
    cl26472
    Location:16281839
    DUF3084; Protein of unknown function (DUF3084)
  6. XM_006710535.3XP_006710598.1  microtubule-actin cross-linking factor 1 isoform X16

    Conserved Domains (8) summary
    smart00150
    Location:69867110
    SPEC; Spectrin repeats
    cd00014
    Location:185288
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71447206
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63246540
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17591799
    Plectin; Plectin repeat
    pfam02187
    Location:72227295
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71457205
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:51185333
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. XM_006710530.3XP_006710593.1  microtubule-actin cross-linking factor 1 isoform X18

    Conserved Domains (8) summary
    smart00150
    Location:69727096
    SPEC; Spectrin repeats
    cd00014
    Location:171274
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71307192
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63106526
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17451785
    Plectin; Plectin repeat
    pfam02187
    Location:72087281
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71317191
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:51045319
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  8. XM_006710528.3XP_006710591.1  microtubule-actin cross-linking factor 1 isoform X15

    Related
    ENSP00000455274.1, OTTHUMP00000250402, ENST00000564288.5, OTTHUMT00000423089
    Conserved Domains (8) summary
    smart00150
    Location:69917115
    SPEC; Spectrin repeats
    cd00014
    Location:190293
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71497211
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63296545
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17641804
    Plectin; Plectin repeat
    pfam02187
    Location:72277300
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71507210
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:51235338
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  9. XM_006710531.3XP_006710594.1  microtubule-actin cross-linking factor 1 isoform X19

    Conserved Domains (8) summary
    smart00150
    Location:69617085
    SPEC; Spectrin repeats
    cd00014
    Location:160263
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71197181
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62996515
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17341774
    Plectin; Plectin repeat
    pfam02187
    Location:71977270
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71207180
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:50935308
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  10. XM_017000878.1XP_016856367.1  microtubule-actin cross-linking factor 1 isoform X20

  11. XM_006710529.3XP_006710592.1  microtubule-actin cross-linking factor 1 isoform X17

    Conserved Domains (8) summary
    smart00150
    Location:69777101
    SPEC; Spectrin repeats
    cd00014
    Location:176279
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:71357197
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63156531
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17501790
    Plectin; Plectin repeat
    pfam02187
    Location:72137286
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:71367196
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:51095324
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  12. XM_017000877.1XP_016856366.1  microtubule-actin cross-linking factor 1 isoform X20

  13. XM_005270694.1XP_005270751.1  microtubule-actin cross-linking factor 1 isoform X1

    Conserved Domains (9) summary
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam02187
    Location:73927465
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  14. XM_006710521.1XP_006710584.1  microtubule-actin cross-linking factor 1 isoform X8

    Conserved Domains (10) summary
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam02187
    Location:73927465
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam05956
    Location:75077684
    APC_basic; APC basic domain
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  15. XM_005270696.1XP_005270753.1  microtubule-actin cross-linking factor 1 isoform X6

    Conserved Domains (9) summary
    smart00243
    Location:73897467
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  16. XM_005270698.1XP_005270755.1  microtubule-actin cross-linking factor 1 isoform X9

    Conserved Domains (10) summary
    smart00243
    Location:73897467
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam05956
    Location:74847661
    APC_basic; APC basic domain
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  17. XM_005270695.1XP_005270752.1  microtubule-actin cross-linking factor 1 isoform X3

    Conserved Domains (9) summary
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam02187
    Location:73927459
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  18. XM_005270697.1XP_005270754.1  microtubule-actin cross-linking factor 1 isoform X7

    Conserved Domains (9) summary
    smart00243
    Location:73897461
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  19. XM_006710522.1XP_006710585.1  microtubule-actin cross-linking factor 1 isoform X11

    Conserved Domains (10) summary
    smart00243
    Location:73897461
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:71567280
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73147376
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64946710
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam05956
    Location:74787655
    APC_basic; APC basic domain
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73157375
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  20. XM_006710519.1XP_006710582.1  microtubule-actin cross-linking factor 1 isoform X2

    Conserved Domains (9) summary
    smart00150
    Location:71537277
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:73117373
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64916707
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam02187
    Location:73897462
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam07793
    Location:38334041
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:73127372
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52885503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  21. XM_017000873.1XP_016856362.1  microtubule-actin cross-linking factor 1 isoform X10

  22. XM_017000874.1XP_016856363.1  microtubule-actin cross-linking factor 1 isoform X12

  23. XM_017000882.1XP_016856371.1  microtubule-actin cross-linking factor 1 isoform X29

  24. XM_006710520.2XP_006710583.1  microtubule-actin cross-linking factor 1 isoform X5

    Conserved Domains (8) summary
    smart00150
    Location:71357259
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:72937355
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64736689
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam02187
    Location:73717444
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:72947354
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52675482
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  25. XM_011541141.2XP_011539443.1  microtubule-actin cross-linking factor 1 isoform X4

    Conserved Domains (9) summary
    smart00150
    Location:71387262
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:72967358
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64766692
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam02187
    Location:73747447
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam07793
    Location:38154023
    DUF1631; Protein of unknown function (DUF1631)
    pfam13499
    Location:72977357
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:52705485
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  26. XM_011541142.2XP_011539444.1  microtubule-actin cross-linking factor 1 isoform X22

    Conserved Domains (8) summary
    smart00150
    Location:53395463
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:54975559
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:46774893
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:14652227
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam02187
    Location:55755648
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:54985558
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:34713686
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  27. XM_006710536.2XP_006710599.1  microtubule-actin cross-linking factor 1 isoform X23

    Conserved Domains (7) summary
    smart00150
    Location:50895213
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:52475309
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:44274643
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam02187
    Location:53255398
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    pfam13499
    Location:52485308
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:32213436
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  28. XM_017000880.1XP_016856369.1  microtubule-actin cross-linking factor 1 isoform X24

  29. XM_006710538.2XP_006710601.1  microtubule-actin cross-linking factor 1 isoform X26

    Conserved Domains (7) summary
    smart00150
    Location:746840
    SPEC; Spectrin repeats
    cd00014
    Location:355458
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:40434271
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:19291969
    Plectin; Plectin repeat
    pfam04012
    Location:38544085
    PspA_IM30; PspA/IM30 family
    pfam07793
    Location:38334059
    DUF1631; Protein of unknown function (DUF1631)
    cl02488
    Location:13241503
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  30. XM_017000879.1XP_016856368.1  microtubule-actin cross-linking factor 1 isoform X21

    Related
    ENSP00000289893.4, OTTHUMP00000009303, ENST00000289893.8, OTTHUMT00000020990

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033044.3: Suppressed sequence

    Description
    NM_033044.3: This RefSeq was permanently suppressed because the CDS was partial.
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