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Macf1 microtubule-actin crosslinking factor 1 [ Mus musculus (house mouse) ]

Gene ID: 11426, updated on 21-Apr-2024

Summary

Official Symbol
Macf1provided by MGI
Official Full Name
microtubule-actin crosslinking factor 1provided by MGI
Primary source
MGI:MGI:108559
See related
Ensembl:ENSMUSG00000028649 AllianceGenome:MGI:108559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acf7; MACF; Aclp7; ABP620; mKIAA0465; mKIAA0754; D830031N03Rik
Summary
Enables actin binding activity and microtubule binding activity. Involved in several processes, including positive regulation of Wnt signaling pathway; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Acts upstream of or within several processes, including Wnt signaling pathway; mesoderm formation; and posttranslational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm; cytoskeleton; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 15.9), CNS E18 (RPKM 10.5) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 D2.2; 4 57.42 cM
Exon count:
109
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123243386..123581594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123349633..123687802, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2118 Neighboring gene poly(A) binding protein, cytoplasmic 4 Neighboring gene predicted gene, 22154 Neighboring gene STARR-seq mESC enhancer starr_11290 Neighboring gene bone morphogenetic protein 8a Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene STARR-seq mESC enhancer starr_11292 Neighboring gene predicted gene 12924 Neighboring gene STARR-positive B cell enhancer ABC_E7985 Neighboring gene STARR-positive B cell enhancer ABC_E11254 Neighboring gene predicted gene, 31156 Neighboring gene STARR-seq mESC enhancer starr_11300 Neighboring gene microRNA 6398 Neighboring gene STARR-seq mESC enhancer starr_11310 Neighboring gene STARR-seq mESC enhancer starr_11311 Neighboring gene predicted gene, 35241 Neighboring gene predicted gene 12925 Neighboring gene STARR-positive B cell enhancer ABC_E2119 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase core subunit S5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0754

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule minus-end binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermediate filament cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of focal adhesion assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microtubule-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron projection arborization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
microtubule-actin cross-linking factor 1
Names
actin cross-linking family 7
actin-crosslinking protein 7
trabeculin alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199136.2NP_001186065.1  microtubule-actin cross-linking factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606918, AL606932
    Consensus CDS
    CCDS57295.1
    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    UniProtKB/TrEMBL
    B1ARU4, E9PVY8
    Related
    ENSMUSP00000101831.3, ENSMUST00000106224.9
    Conserved Domains (8) summary
    smart00243
    Location:70817159
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:68446968
    SPEC; Spectrin repeats
    cd00014
    Location:79181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:70067068
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:61826398
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:17691809
    Plectin; Plectin repeat
    pfam13499
    Location:70077067
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:50885303
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. NM_001199137.2NP_001186066.1  microtubule-actin cross-linking factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606918, AL606932
    Consensus CDS
    CCDS57294.1
    UniProtKB/TrEMBL
    A0A0A0MQA6, A0A571BGC6
    Related
    ENSMUSP00000080755.6, ENSMUST00000082108.12
    Conserved Domains (7) summary
    smart00243
    Location:50545132
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:48174941
    SPEC; Spectrin repeats
    cd00014
    Location:79181
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00051
    Location:49795041
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:41554371
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam13499
    Location:49805040
    EF-hand_7; EF-hand domain pair
    cl02488
    Location:30613276
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. NM_001401293.2NP_001388222.1  microtubule-actin cross-linking factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606918
    UniProtKB/Swiss-Prot
    Q69ZZ9
  4. NM_001401294.2NP_001388223.1  microtubule-actin cross-linking factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606918

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    123243386..123581594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240417.3XP_011238719.2  microtubule-actin cross-linking factor 1 isoform X9

    UniProtKB/TrEMBL
    F7ACR9
    Conserved Domains (12) summary
    smart00243
    Location:51775249
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:49445068
    SPEC; Spectrin repeats
    PHA03307
    Location:52705443
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:12551726
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:21612978
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:16641862
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    COG5069
    Location:109333
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:51025164
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:42824498
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:28303760
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
  2. XM_030253097.2XP_030108957.1  microtubule-actin cross-linking factor 1 isoform X10

    UniProtKB/TrEMBL
    A0A571BGC6
    Conserved Domains (11) summary
    smart00243
    Location:50905168
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:48534977
    SPEC; Spectrin repeats
    PHA03307
    Location:51895362
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:21612999
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:109333
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:50155077
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:41914407
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:28513672
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11561908
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
  3. XM_011240416.3XP_011238718.2  microtubule-actin cross-linking factor 1 isoform X7

    UniProtKB/TrEMBL
    F7ACR9
    Related
    ENSMUSP00000114568.2, ENSMUST00000151346.8
    Conserved Domains (11) summary
    smart00243
    Location:51985270
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:49655089
    SPEC; Spectrin repeats
    PHA03307
    Location:52915464
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:21612999
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:109333
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:51235185
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:43034519
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:28513781
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11561908
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
  4. XM_036163593.1XP_036019486.1  microtubule-actin cross-linking factor 1 isoform X6

    UniProtKB/TrEMBL
    F7ACR9
    Conserved Domains (12) summary
    smart00243
    Location:52035278
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:49655089
    SPEC; Spectrin repeats
    PHA03307
    Location:54195534
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:21612999
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:51285190
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:43034519
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:28513781
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:11561908
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113217
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cl00030
    Location:228334
    CH_SF; calponin homology (CH) domain superfamily
  5. XM_036163597.1XP_036019490.1  microtubule-actin cross-linking factor 1 isoform X13

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (13) summary
    smart00243
    Location:71137188
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:68807004
    SPEC; Spectrin repeats
    PHA03307
    Location:73297444
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:41885026
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:70387100
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62186434
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48785699
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:18051841
    Plectin; Plectin repeat
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113217
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cd21240
    Location:228334
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:12001379
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. XM_030253096.2XP_030108956.1  microtubule-actin cross-linking factor 1 isoform X2

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (12) summary
    smart00243
    Location:71177195
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:68807004
    SPEC; Spectrin repeats
    PHA03307
    Location:72167389
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:41885026
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:109333
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:70427104
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62186434
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48785699
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:12001379
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:18051845
    Plectin; Plectin repeat
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
  7. XM_011240411.3XP_011238713.2  microtubule-actin cross-linking factor 1 isoform X3

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (12) summary
    smart00243
    Location:71167188
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:68837007
    SPEC; Spectrin repeats
    PHA03307
    Location:72097382
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:41885026
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5069
    Location:109333
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:70417103
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:62216437
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48785699
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl02488
    Location:12001379
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00681
    Location:18051845
    Plectin; Plectin repeat
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
  8. XM_036163600.1XP_036019493.1  microtubule-actin cross-linking factor 1 isoform X16

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (13) summary
    smart00243
    Location:72227294
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:69897113
    SPEC; Spectrin repeats
    PHA03307
    Location:74097524
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:41885026
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:71477209
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63276543
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48785808
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:18051841
    Plectin; Plectin repeat
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113217
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cd21240
    Location:228334
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:12001379
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  9. XM_036163599.1XP_036019492.1  microtubule-actin cross-linking factor 1 isoform X15

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (13) summary
    smart00243
    Location:72227300
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:69897113
    SPEC; Spectrin repeats
    PHA03307
    Location:74157530
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:41885026
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:71477209
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63276543
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48785808
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:18051841
    Plectin; Plectin repeat
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113217
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cd21240
    Location:228334
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:12001379
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  10. XM_036163598.1XP_036019491.1  microtubule-actin cross-linking factor 1 isoform X14

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (13) summary
    smart00243
    Location:72227297
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:69897113
    SPEC; Spectrin repeats
    PHA03307
    Location:74387553
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:41885026
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:71477209
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63276543
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:48785808
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:18051841
    Plectin; Plectin repeat
    pfam17902
    Location:893959
    SH3_10; SH3 domain
    pfam18373
    Location:9941071
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113217
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cd21240
    Location:228334
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:12001379
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  11. XM_036163596.1XP_036019489.1  microtubule-actin cross-linking factor 1 isoform X12

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (13) summary
    smart00243
    Location:72547332
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:70217145
    SPEC; Spectrin repeats
    PHA03307
    Location:74477562
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:42205058
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:71797241
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63596575
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49105840
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:18371873
    Plectin; Plectin repeat
    pfam17902
    Location:925991
    SH3_10; SH3 domain
    pfam18373
    Location:10261103
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113249
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cd21240
    Location:260366
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:12321411
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  12. XM_036163595.1XP_036019488.1  microtubule-actin cross-linking factor 1 isoform X11

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (13) summary
    smart00243
    Location:72547329
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:70217145
    SPEC; Spectrin repeats
    PHA03307
    Location:74707585
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:42205058
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:71797241
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:63596575
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49105840
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:18371873
    Plectin; Plectin repeat
    pfam17902
    Location:925991
    SH3_10; SH3 domain
    pfam18373
    Location:10261103
    Spectrin_like; Spectrin like domain
    cd21188
    Location:113249
    CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
    cd21240
    Location:260366
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:12321411
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  13. XM_036163594.1XP_036019487.1  microtubule-actin cross-linking factor 1 isoform X8

    UniProtKB/TrEMBL
    F7ACR9
    Conserved Domains (12) summary
    smart00243
    Location:51255200
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:48875011
    SPEC; Spectrin repeats
    PHA03307
    Location:53415456
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:20832921
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:50505112
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:42254441
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:27733703
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:10781830
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17902
    Location:815881
    SH3_10; SH3 domain
    pfam18373
    Location:916993
    Spectrin_like; Spectrin like domain
    cd21236
    Location:21148
    CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins
    cl00030
    Location:150256
    CH_SF; calponin homology (CH) domain superfamily
  14. XM_036163591.1XP_036019484.1  microtubule-actin cross-linking factor 1 isoform X4

    UniProtKB/TrEMBL
    F7ACR9
    Conserved Domains (11) summary
    smart00243
    Location:53185393
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:50805204
    SPEC; Spectrin repeats
    PHA03307
    Location:55345649
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:22763114
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:52435305
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:44184634
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:29663896
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:10722023
    CCDC158; Coiled-coil domain-containing protein 158
    pfam17902
    Location:10081074
    SH3_10; SH3 domain
    pfam18373
    Location:11091186
    Spectrin_like; Spectrin like domain
    cl00030
    Location:343449
    CH_SF; calponin homology (CH) domain superfamily
  15. XM_036163592.1XP_036019485.1  microtubule-actin cross-linking factor 1 isoform X5

    UniProtKB/TrEMBL
    F7ACR9
    Conserved Domains (12) summary
    smart00243
    Location:52995374
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:50615185
    SPEC; Spectrin repeats
    PHA03307
    Location:55155630
    PHA03307; transcriptional regulator ICP4; Provisional
    COG0419
    Location:13721843
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:22783095
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG4372
    Location:17811979
    COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
    cd00051
    Location:52245286
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:43994615
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:29473877
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam17902
    Location:10101076
    SH3_10; SH3 domain
    pfam18373
    Location:11111188
    Spectrin_like; Spectrin like domain
    cl00030
    Location:343449
    CH_SF; calponin homology (CH) domain superfamily
  16. XM_036163590.1XP_036019483.1  microtubule-actin cross-linking factor 1 isoform X1

    UniProtKB/Swiss-Prot
    B1ARU3, P97394, P97395, P97396, Q4PLL5, Q9QXZ0
    Conserved Domains (12) summary
    smart00243
    Location:73427420
    GAS2; Growth-Arrest-Specific Protein 2 Domain
    smart00150
    Location:71097233
    SPEC; Spectrin repeats
    PHA03307
    Location:74417614
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:43055143
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00051
    Location:72677329
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:64476663
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:49955925
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00681
    Location:19221958
    Plectin; Plectin repeat
    pfam17902
    Location:10101076
    SH3_10; SH3 domain
    pfam18373
    Location:11111188
    Spectrin_like; Spectrin like domain
    cd21240
    Location:343449
    CH_MACF1_rpt2; second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins
    cl02488
    Location:13171496
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001167918.1: Suppressed sequence

    Description
    NM_001167918.1: This RefSeq was removed because currently there is insufficient support for the transcript.
  2. NM_009600.3: Suppressed sequence

    Description
    NM_009600.3: This RefSeq was removed because currently there is insufficient support for the transcript.