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CDK19 cyclin dependent kinase 19 [ Homo sapiens (human) ]

Gene ID: 23097, updated on 21-Dec-2019

Summary

Official Symbol
CDK19provided by HGNC
Official Full Name
cyclin dependent kinase 19provided by HGNC
Primary source
HGNC:HGNC:19338
See related
Ensembl:ENSG00000155111 MIM:614720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDK11; CDC2L6; bA346C16.3
Summary
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Expression
Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues See more
Orthologs

Genomic context

See CDK19 in Genome Data Viewer
Location:
6q21
Exon count:
22
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (110609978..110816531, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (110931181..111136590, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377941 Neighboring gene abhydrolase domain containing 10 pseudogene Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 pseudogene Neighboring gene ribosomal protein S20 pseudogene 18 Neighboring gene RNA, U6 small nuclear 957, pseudogene Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene RNA, U6 small nuclear 1115, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 40C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1028

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 19
Names
CDC2-related protein kinase 6
CDK8-like cyclin-dependent kinase
cell division cycle 2-like 6 (CDK8-like)
cell division cycle 2-like protein kinase 6
cell division protein kinase 19
cyclin dependent kinase 19 variant 2
cyclin-dependent kinase (CDC2-like) 11
cyclin-dependent kinase 11
death-preventing kinase
NP_001287889.1
NP_001287892.1
NP_001287893.1
NP_055891.1
XP_005266928.1
XP_011533932.1
XP_011533933.1
XP_011533934.2
XP_016866076.1
XP_016866077.1
XP_024302144.1
XP_024302145.1
XP_024302146.1
XP_024302147.1
XP_024302148.1
XP_024302149.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300960.2NP_001287889.1  cyclin-dependent kinase 19 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AB028951, AY028424, JX028238, Z84480
    UniProtKB/Swiss-Prot
    Q9BWU1
    UniProtKB/TrEMBL
    I6W807
    Related
    ENSP00000410604.3, ENST00000413605.6
    Conserved Domains (2) summary
    smart00220
    Location:22291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:18291
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001300963.1NP_001287892.1  cyclin-dependent kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001287892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AB028951, BC024247
    Consensus CDS
    CCDS75503.1
    UniProtKB/Swiss-Prot
    Q9BWU1
    Related
    ENSP00000317665.3, ENST00000323817.7
    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001300964.2NP_001287893.1  cyclin-dependent kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001287893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
    Source sequence(s)
    AB028951, DB030002
    Consensus CDS
    CCDS75503.1
    UniProtKB/Swiss-Prot
    Q9BWU1
    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  4. NM_015076.5NP_055891.1  cyclin-dependent kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_055891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB028951, AY028424, Z84480
    Consensus CDS
    CCDS5085.1
    UniProtKB/Swiss-Prot
    Q9BWU1
    Related
    ENSP00000357907.3, ENST00000368911.8
    Conserved Domains (1) summary
    cd07867
    Location:18335
    STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    110609978..110816531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535630.2XP_011533932.1  cyclin-dependent kinase 19 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:139388
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:141388
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011535631.2XP_011533933.1  cyclin-dependent kinase 19 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:141348
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024446376.1XP_024302144.1  cyclin-dependent kinase 19 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:141432
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017010587.2XP_016866076.1  cyclin-dependent kinase 19 isoform X5

  5. XM_024446377.1XP_024302145.1  cyclin-dependent kinase 19 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017010588.1XP_016866077.1  cyclin-dependent kinase 19 isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:1162
    PKc_like; Protein Kinases, catalytic domain
  7. XM_024446380.1XP_024302148.1  cyclin-dependent kinase 19 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  8. XM_024446379.1XP_024302147.1  cyclin-dependent kinase 19 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  9. XM_024446378.1XP_024302146.1  cyclin-dependent kinase 19 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  10. XM_024446381.1XP_024302149.1  cyclin-dependent kinase 19 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1275
    PKc_like; Protein Kinases, catalytic domain
  11. XM_005266871.3XP_005266928.1  cyclin-dependent kinase 19 isoform X7

    See identical proteins and their annotated locations for XP_005266928.1

    UniProtKB/TrEMBL
    B4DUB1
    Conserved Domains (1) summary
    cl21453
    Location:28211
    PKc_like; Protein Kinases, catalytic domain
  12. XM_011535632.2XP_011533934.2  cyclin-dependent kinase 19 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:141387
    PKc_like; Protein Kinases, catalytic domain
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