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Cdk19 cyclin-dependent kinase 19 [ Mus musculus (house mouse) ]

Gene ID: 78334, updated on 16-Oct-2021

Summary

Official Symbol
Cdk19provided by MGI
Official Full Name
cyclin-dependent kinase 19provided by MGI
Primary source
MGI:MGI:1925584
See related
Ensembl:ENSMUSG00000038481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDK11; Cdc2l6; AI845279; AW228747; mKIAA1028; 2700084L06Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.6), cortex adult (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

See Cdk19 in Genome Data Viewer
Location:
10; 10 B1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40225283..40359814)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40349287..40483818)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (40069114..40203624)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase 1 Neighboring gene predicted gene 8948 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32234 Neighboring gene small nuclear ribonucleoprotein B pseudogene Neighboring gene fragile X mental retardation gene 1, autosomal homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 19
Names
CDC2-related protein kinase 6
cell division cycle 2-like 6 (CDK8-like)
cell division cycle 2-like protein kinase 6
cell division protein kinase 19
cyclin-dependent kinase (CDC2-like) 11
cyclin-dependent kinase 11
NP_001161776.1
NP_001278745.1
NP_001278746.1
NP_937807.2
XP_017169653.1
XP_030101250.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168304.1NP_001161776.1  cyclin-dependent kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_001161776.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC142273, AC157652, AK053651, BC080280
    Consensus CDS
    CCDS48545.1
    UniProtKB/Swiss-Prot
    Q8BWD8
    UniProtKB/TrEMBL
    B7ZMT1, Q8BKC7
    Related
    ENSMUSP00000040936.5, ENSMUST00000044672.11
    Conserved Domains (2) summary
    smart00220
    Location:22335
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07867
    Location:18335
    STKc_CDC2L6; Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6
  2. NM_001291816.1NP_001278745.1  cyclin-dependent kinase 19 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC142273, AK147340, BC080280
    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001291817.1NP_001278746.1  cyclin-dependent kinase 19 isoform 4

    See identical proteins and their annotated locations for NP_001278746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC142273, AK147340, BC062100, BC080280
    Conserved Domains (1) summary
    cl21453
    Location:1162
    PKc_like; Protein Kinases, catalytic domain
  4. NM_198164.3NP_937807.2  cyclin-dependent kinase 19 isoform 2

    See identical proteins and their annotated locations for NP_937807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a short protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC142273, AK053651, AK147340, BC080280
    Consensus CDS
    CCDS23795.1
    UniProtKB/TrEMBL
    G5E8L1, Q8BKC7
    Related
    ENSMUSP00000093414.3, ENSMUST00000095743.4
    Conserved Domains (2) summary
    smart00220
    Location:22291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:18291
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    40225283..40359814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245390.1XP_030101250.1  cyclin-dependent kinase 19 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1162
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017314164.3XP_017169653.1  cyclin-dependent kinase 19 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1215
    PKc_like; Protein Kinases, catalytic domain
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