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LRWD1 leucine rich repeats and WD repeat domain containing 1 [ Homo sapiens (human) ]

Gene ID: 222229, updated on 15-Jun-2019

Summary

Official Symbol
LRWD1provided by HGNC
Official Full Name
leucine rich repeats and WD repeat domain containing 1provided by HGNC
Primary source
HGNC:HGNC:21769
See related
Ensembl:ENSG00000161036 MIM:615167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORCA; CENP-33
Summary
The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is required for the G1/S phase transition of the cell cycle. In addition, the encoded protein binds to trimethylated histone H3 in heterochromatin and recruits the ORC and lysine methyltransferases, which help maintain the repressive heterochromatic state. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 101.1) and bone marrow (RPKM 5.9) See more
Orthologs

Genomic context

See LRWD1 in Genome Data Viewer
Location:
7q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (102464883..102473168)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102105335..102113615)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene LOC100289561-PRKRIP1 readthrough Neighboring gene uncharacterized LOC105375433 Neighboring gene PRKR interacting protein 1 Neighboring gene ORAI calcium release-activated calcium modulator 2 Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene microRNA 5090 Neighboring gene microRNA 4467 Neighboring gene RNA polymerase II subunit J Neighboring gene RAS p21 protein activator 4B Neighboring gene uroplakin 3B like 2 Neighboring gene RNA polymerase II subunit J3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434K1815

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA replication initiation TAS
Traceable Author Statement
more info
PubMed 
chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization to chromatin IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
telomeric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat and WD repeat-containing protein 1
Names
ORC-associated protein
centromere protein 33
origin recognition complex-associated protein
testicular tissue protein Li 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317721.1NP_001304650.1  leucine-rich repeat and WD repeat-containing protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC009436, BC030547, HY037356, HY051509
    UniProtKB/Swiss-Prot
    Q9UFC0
    Conserved Domains (3) summary
    COG2319
    Location:157432
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:206238
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:156429
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_152892.3NP_690852.1  leucine-rich repeat and WD repeat-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_690852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009436, BC030547
    Consensus CDS
    CCDS34715.1
    UniProtKB/Swiss-Prot
    Q9UFC0
    UniProtKB/TrEMBL
    A0A140VJD0
    Related
    ENSP00000292616.5, ENST00000292616.10
    Conserved Domains (6) summary
    COG2319
    Location:309584
    WD40; WD40 repeat [General function prediction only]
    sd00031
    Location:2348
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:4787
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:47103
    LRR_8; Leucine rich repeat
    sd00039
    Location:295337
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:308581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    102464883..102473168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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