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Lrwd1 leucine-rich repeats and WD repeat domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 71735, updated on 8-Jun-2024

Summary

Official Symbol
Lrwd1provided by MGI
Official Full Name
leucine-rich repeats and WD repeat domain containing 1provided by MGI
Primary source
MGI:MGI:1918985
See related
Ensembl:ENSMUSG00000029703 AllianceGenome:MGI:1918985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orca; 1200011O22Rik
Summary
Predicted to enable chromatin binding activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in chromatin organization and establishment of protein localization to chromatin. Predicted to act upstream of or within DNA replication. Predicted to be located in chromosomal region and nuclear lumen. Predicted to be part of nuclear origin of replication recognition complex. Orthologous to human LRWD1 (leucine rich repeats and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 134.7), thymus adult (RPKM 40.8) and 22 other tissues See more
Orthologs
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Genomic context

See Lrwd1 in Genome Data Viewer
Location:
5 G2; 5 75.8 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136151920..136164928, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136123066..136136074, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 4 Neighboring gene microRNA 7035 Neighboring gene STARR-positive B cell enhancer ABC_E856 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide J Neighboring gene STARR-positive B cell enhancer ABC_E6388 Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene ORAI calcium release-activated calcium modulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E3629

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization to chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leucine-rich repeat and WD repeat-containing protein 1
Names
ORC-associated protein
origin recognition complex-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027891.4NP_082167.2  leucine-rich repeat and WD repeat-containing protein 1

    See identical proteins and their annotated locations for NP_082167.2

    Status: VALIDATED

    Source sequence(s)
    AA620153, AK084948, BY142519
    Consensus CDS
    CCDS51666.1
    UniProtKB/Swiss-Prot
    D3Z2P9, Q3TIG2, Q8BKI3, Q8BUI3, Q9DBW4
    Related
    ENSMUSP00000006301.5, ENSMUST00000006301.11
    Conserved Domains (6) summary
    COG2319
    Location:365585
    WD40; WD40 repeat [General function prediction only]
    sd00031
    Location:2348
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:4787
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:47103
    LRR_8; Leucine rich repeat
    sd00039
    Location:345391
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:295585
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136151920..136164928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)