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TMEM192 transmembrane protein 192 [ Homo sapiens (human) ]

Gene ID: 201931, updated on 24-Nov-2020

Summary

Official Symbol
TMEM192provided by HGNC
Official Full Name
transmembrane protein 192provided by HGNC
Primary source
HGNC:HGNC:26775
See related
Ensembl:ENSG00000170088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in kidney (RPKM 15.7), thyroid (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See TMEM192 in Genome Data Viewer
Location:
4q32.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (165070608..165112913, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (165997230..166034024, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 60 Neighboring gene tripartite motif containing 75, pseudogene Neighboring gene kelch like family member 2 Neighboring gene RNA, U4 small nuclear 87, pseudogene Neighboring gene glycerol kinase 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with transmembrane protein 192 (TMEM192) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38482

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
NOT endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
NOT plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100389.2NP_001093859.1  transmembrane protein 192

    See identical proteins and their annotated locations for NP_001093859.1

    Status: VALIDATED

    Source sequence(s)
    AA346826, AC108465, AW137472, BC036301
    Consensus CDS
    CCDS43279.1
    UniProtKB/Swiss-Prot
    Q8IY95
    Related
    ENSP00000305069.4, ENST00000306480.11
    Conserved Domains (1) summary
    pfam14802
    Location:26259
    TMEM192; TMEM192 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    165070608..165112913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531717.3XP_011530019.1  transmembrane protein 192 isoform X1

    Conserved Domains (1) summary
    pfam14802
    Location:26226
    TMEM192; TMEM192 family
  2. XM_011531718.3XP_011530020.1  transmembrane protein 192 isoform X2

    Conserved Domains (1) summary
    pfam14802
    Location:26214
    TMEM192; TMEM192 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152681.1: Suppressed sequence

    Description
    NM_152681.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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