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EGR4 early growth response 4 [ Homo sapiens (human) ]

Gene ID: 1961, updated on 11-Sep-2019

Summary

Official Symbol
EGR4provided by HGNC
Official Full Name
early growth response 4provided by HGNC
Primary source
HGNC:HGNC:3241
See related
Ensembl:ENSG00000135625 MIM:128992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT133; NGFIC; NGFI-C; PAT133
Expression
Biased expression in brain (RPKM 3.5) and testis (RPKM 1.6) See more
Orthologs

Genomic context

See EGR4 in Genome Data Viewer
Location:
2p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73290929..73293548, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73518057..73520829, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41 Neighboring gene RNA, U6 small nuclear 111, pseudogene Neighboring gene uncharacterized LOC105374802

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of early growth response 4 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
early growth response protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001965.4NP_001956.4  early growth response protein 4

    Status: VALIDATED

    Source sequence(s)
    AC010913
    Consensus CDS
    CCDS1925.2
    Related
    ENSP00000419687.1, ENST00000436467.3
    Conserved Domains (3) summary
    COG5048
    Location:408466
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382404
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:74339
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    73290929..73293548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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