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Egr4 early growth response 4 [ Mus musculus (house mouse) ]

Gene ID: 13656, updated on 7-May-2024

Summary

Official Symbol
Egr4provided by MGI
Official Full Name
early growth response 4provided by MGI
Primary source
MGI:MGI:99252
See related
Ensembl:ENSMUSG00000071341 AllianceGenome:MGI:99252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NGFIC; NGF1-C; NGFI-C; pAT133
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; and tooth. Orthologous to human EGR4 (early growth response 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 10.9), cortex adult (RPKM 9.9) and 2 other tissues See more
Orthologs
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Genomic context

See Egr4 in Genome Data Viewer
Location:
6 C3; 6 37.48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85488103..85490571, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85511121..85513589, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene protease-associated domain containing 1 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41 Neighboring gene ALMS1, centrosome and basal body associated Neighboring gene STARR-seq mESC enhancer starr_16505 Neighboring gene STARR-seq mESC enhancer starr_16506 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 7 Neighboring gene ALMS1, centrosome and basal body associated, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General protein information

Preferred Names
early growth response protein 4
Names
EGR-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020596.3NP_065621.1  early growth response protein 4

    See identical proteins and their annotated locations for NP_065621.1

    Status: VALIDATED

    Source sequence(s)
    AK141637, BX528200
    Consensus CDS
    CCDS20297.1
    UniProtKB/Swiss-Prot
    Q9WUF2
    UniProtKB/TrEMBL
    Q3URA9
    Related
    ENSMUSP00000093433.4, ENSMUST00000095759.5
    Conserved Domains (4) summary
    COG5048
    Location:400458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372396
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:416441
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85488103..85490571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)