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EGFR epidermal growth factor receptor [ Homo sapiens (human) ]

Gene ID: 1956, updated on 4-Dec-2020

Summary

Official Symbol
EGFRprovided by HGNC
Official Full Name
epidermal growth factor receptorprovided by HGNC
Primary source
HGNC:HGNC:3236
See related
Ensembl:ENSG00000146648 MIM:131550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Summary
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Broad expression in placenta (RPKM 36.6), skin (RPKM 15.6) and 22 other tissues See more
Orthologs

Genomic context

See EGFR in Genome Data Viewer
Location:
7p11.2
Exon count:
31
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (55019017..55211628)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (55086678..55279262)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene SEC61G divergent transcript Neighboring gene Rho GTPase activating protein 5 pseudogene Neighboring gene uncharacterized LOC105375284 Neighboring gene EGFR antisense RNA 1 Neighboring gene solute carrier family 19 member 3 pseudogene Neighboring gene calmodulin 1 pseudogene 2 Neighboring gene EGFR long non-coding downstream RNA

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cetuximab response
MedGen: CN077967 GeneReviews: Not available
Compare labs
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
GeneReviews: Not available
Inflammatory skin and bowel disease, neonatal, 2
MedGen: C4015130 OMIM: 616069 GeneReviews: Not available
Compare labs
Panitumumab response
MedGen: CN077999 GeneReviews: Not available
Compare labs

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of epidermal growth factor receptor (EGFR) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Expression of HIV-1 Gag decreases the rate of EGFR downregulation by ESCRT proteins at endosomal membranes, an effect that is dependent on the presence of the TSG101 binding motif (PTAP) within the Gag C-terminal p6 domain PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
MAP kinase kinase kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to nitric-oxide synthase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of phospholipase A2 activity by calcium-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
activation of phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
astrocyte activation IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to dexamethasone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to epidermal growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex cell migration IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
diterpenoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
eyelid development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
learning or memory ISS
Inferred from Sequence or Structural Similarity
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
magnesium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
midgut development IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of an epithelial fold IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of ERBB signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of Notch signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ossification NAS
Non-traceable Author Statement
more info
PubMed 
ovulation cycle IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of prolactin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein insertion into membrane TAS
Traceable Author Statement
more info
PubMed 
regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell motility TAS
Traceable Author Statement
more info
 
regulation of nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
response to cobalamin IEA
Inferred from Electronic Annotation
more info
 
response to hydroxyisoflavone IEA
Inferred from Electronic Annotation
more info
 
response to osmotic stress IEA
Inferred from Electronic Annotation
more info
 
salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
 
tongue development IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Shc-EGFR complex ISS
Inferred from Sequence or Structural Similarity
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
focal adhesion HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
multivesicular body, internal vesicle lumen IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
epidermal growth factor receptor
Names
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
cell growth inhibiting protein 40
cell proliferation-inducing protein 61
epidermal growth factor receptor tyrosine kinase domain
erb-b2 receptor tyrosine kinase 1
proto-oncogene c-ErbB-1
receptor tyrosine-protein kinase erbB-1
NP_001333826.1
NP_001333827.1
NP_001333828.1
NP_001333829.1
NP_001333870.1
NP_005219.2
NP_958439.1
NP_958440.1
NP_958441.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007726.3 RefSeqGene

    Range
    5001..193307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_304

mRNA and Protein(s)

  1. NM_001346897.2NP_001333826.1  epidermal growth factor receptor isoform e precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region and its 3' terminal exon extends past a splice site that is used in variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC006977, AC073324, BC094761
    Consensus CDS
    CCDS87507.1
    UniProtKB/TrEMBL
    Q504U8
    Related
    ENSP00000415559.1, ENST00000455089.5
  2. NM_001346898.2NP_001333827.1  epidermal growth factor receptor isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a 3' terminal exon that extends past a splice site that is used in variant 1. The encoded isoform (f) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC006977, AC073324, BC094761, GU255993, HQ912715
    UniProtKB/TrEMBL
    E7BSV0, F2YGG7, Q504U8
  3. NM_001346899.2NP_001333828.1  epidermal growth factor receptor isoform g precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AC006977, AC073324, AW450657, BC094761, DA371223, HQ912715
    Consensus CDS
    CCDS87506.1
    UniProtKB/TrEMBL
    E9PFD7, F2YGG7, Q504U8
    Related
    ENSP00000395243.3, ENST00000454757.6
  4. NM_001346900.2NP_001333829.1  epidermal growth factor receptor isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses a novel 5' terminal exon compared to variant 1. The encoded isoform (h) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC006977, AC073324, AK294750, AW450657, DA371223, DC347326, HQ912715
    UniProtKB/TrEMBL
    B7Z2I3, F2YGG7
  5. NM_001346941.2NP_001333870.1  epidermal growth factor receptor isoform i precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (EGFRvIII, also known as delta-EGFR and de2-7EGFR) has an in-frame deletion of six exons in the 5' coding region, compared to variant 1. The encoded isoform (i) has a shorter extracellular domain compared to isoform a. This variant is considered to be tumorigenic and the encoded protein lacks normal ligand binding ability and is constitutively active (PMID: 23777544).
    Source sequence(s)
    AC006977, AC073324
  6. NM_005228.5NP_005219.2  epidermal growth factor receptor isoform a precursor

    See identical proteins and their annotated locations for NP_005219.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC006977, AC073324, AF125253, AU137334, AW450657, BC094761, DA371223, HQ912715, X00588
    Consensus CDS
    CCDS5514.1
    UniProtKB/Swiss-Prot
    P00533
    UniProtKB/TrEMBL
    F2YGG7, Q504U8
    Related
    ENSP00000275493.2, ENST00000275493.7
    Conserved Domains (8) summary
    smart00219
    Location:713968
    TyrKc; Tyrosine kinase, catalytic domain
    cd12093
    Location:634677
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:7041016
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:185335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505637
    GF_recep_IV; Growth factor receptor domain IV
  7. NM_201282.2NP_958439.1  epidermal growth factor receptor isoform b precursor

    See identical proteins and their annotated locations for NP_958439.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform b.
    Source sequence(s)
    AC006977, AF125253, AF277897, AW163038, X00588
    Consensus CDS
    CCDS5516.1
    UniProtKB/Swiss-Prot
    P00533
    Related
    ENSP00000342376.3, ENST00000342916.7
    Conserved Domains (5) summary
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:185335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505627
    GF_recep_IV; Growth factor receptor domain IV
  8. NM_201283.2NP_958440.1  epidermal growth factor receptor isoform c precursor

    See identical proteins and their annotated locations for NP_958440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as ErbB1-S) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform c.
    Source sequence(s)
    AC006977, AW163038, U48722, X00588
    Consensus CDS
    CCDS47587.1
    UniProtKB/Swiss-Prot
    P00533
    Related
    ENSP00000413843.2, ENST00000420316.6
    Conserved Domains (3) summary
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:185335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
  9. NM_201284.2NP_958441.1  epidermal growth factor receptor isoform d precursor

    See identical proteins and their annotated locations for NP_958441.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses a different 3' terminal exon when compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus. Only the extracellular domain is present in isoform d.
    Source sequence(s)
    AC006977, AF125253, AW163038, X00588
    Consensus CDS
    CCDS5515.1
    UniProtKB/Swiss-Prot
    P00533
    Related
    ENSP00000345973.2, ENST00000344576.6
    Conserved Domains (5) summary
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:185335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505627
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    55019017..55211628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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