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Egfr epidermal growth factor receptor [ Mus musculus (house mouse) ]

Gene ID: 13649, updated on 22-Jan-2023

Summary

Official Symbol
Egfrprovided by MGI
Official Full Name
epidermal growth factor receptorprovided by MGI
Primary source
MGI:MGI:95294
See related
Ensembl:ENSMUSG00000020122 AllianceGenome:MGI:95294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wa5; wa2; Erbb; Errp; wa-2; Errb1; 9030024J15Rik
Summary
Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 26.7), liver E18 (RPKM 8.7) and 15 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Egfr in Genome Data Viewer
Location:
11 A2; 11 9.41 cM
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16700153..16868158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16752203..16913907)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12664 Neighboring gene predicted gene, 39583 Neighboring gene predicted gene, 25698 Neighboring gene predicted gene, 39584 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene Egfr long non-coding downstream RNA Neighboring gene F-box protein 48 Neighboring gene pleckstrin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables epidermal growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables epidermal growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables epidermal growth factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables epidermal growth factor receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables epidermal growth factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables epidermal growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERBB2-EGFR signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERBB2-EGFR signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ERBB2-EGFR signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eyelid development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in magnesium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within morphogenesis of an epithelial fold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ovulation cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mucus secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prolactin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in translation ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body, internal vesicle lumen ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epidermal growth factor receptor
Names
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
waved 2
NP_031938.1
NP_997538.1
XP_036012181.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007912.4NP_031938.1  epidermal growth factor receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_031938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK004883, AK004944
    Consensus CDS
    CCDS24444.1
    UniProtKB/TrEMBL
    Q5SVE9, Q9WVF5
    Related
    ENSMUSP00000099948.4, ENSMUST00000102884.10
    Conserved Domains (5) summary
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:184335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505636
    GF_recep_IV; Growth factor receptor domain IV
  2. NM_207655.2NP_997538.1  epidermal growth factor receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_997538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF275367, AK004883, AK163338, BQ553815, BY725722
    Consensus CDS
    CCDS24443.1
    UniProtKB/Swiss-Prot
    Q01279
    UniProtKB/TrEMBL
    Q3TQS6, Q9EP98, Q9WVF5
    Related
    ENSMUSP00000020329.7, ENSMUST00000020329.13
    Conserved Domains (8) summary
    smart00219
    Location:715970
    TyrKc; Tyrosine kinase, catalytic domain
    cd12093
    Location:634679
    TM_ErbB1; Transmembrane domain of Epidermal Growth Factor Receptor or ErbB1, a Protein Tyrosine Kinase
    smart00261
    Location:552598
    FU; Furin-like repeats
    cd00064
    Location:231274
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    cd05108
    Location:7061018
    PTKc_EGFR; Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor
    pfam00757
    Location:184335
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:57168
    Recep_L_domain; Receptor L domain
    pfam14843
    Location:505636
    GF_recep_IV; Growth factor receptor domain IV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16700153..16868158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156288.1XP_036012181.1  epidermal growth factor receptor isoform X1