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DYNC1H1 dynein cytoplasmic 1 heavy chain 1 [ Homo sapiens (human) ]

Gene ID: 1778, updated on 5-Jul-2020

Summary

Official Symbol
DYNC1H1provided by HGNC
Official Full Name
dynein cytoplasmic 1 heavy chain 1provided by HGNC
Primary source
HGNC:HGNC:2961
See related
Ensembl:ENSG00000197102 MIM:600112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p22; DHC1; DNCL; DYHC; HL-3; CMT2O; DHC1a; DNCH1; DNECL; Dnchc1; SMALED1
Summary
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in brain (RPKM 38.0), skin (RPKM 23.8) and 25 other tissues See more
Orthologs

Genomic context

See DYNC1H1 in Genome Data Viewer
Location:
14q32.31
Exon count:
78
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (101964573..102056443)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102430865..102517135)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit B'gamma Neighboring gene uncharacterized LOC107984659 Neighboring gene nucleophosmin 1 pseudogene 20 Neighboring gene uncharacterized LOC107984661 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene heat shock protein 90 alpha family class A member 1 Neighboring gene WD repeat domain 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Dynein heavy chain knockdown by siRNA enhances HIV-1 infectivity in TRIMCyp-expressing HeLa cells but not in TRIMCyp-expressing owl monkey cells PubMed
Knockdown of dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag SiRNA-mediated depletion of the dynein heavy chain leads to a marked relocalization of vRNA and viral structural protein Gag to the cell periphery with late endosomes and a several fold increase in HIV-1 production PubMed
Rev rev HIV-1 Rev interacting protein, dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
Vpr vpr HIV-1 Vpr relocalizes DYNC1H1 (DHC) in transfected HeLa cells PubMed
vpr HIV-1 Vpr is identified to have a physical interaction with dynein, cytoplasmic 1, heavy chain 1 (DYNC1H1) in human HEK293, HeLa and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
vpr HIV-1 uncoating is facilitated by dynein motor function since siRNA knockdown of DYNC1H1 increases the amount of HIV-1 p24 associated with Vpr-associated cytoplasmic virions PubMed
capsid gag HIV-1 uncoating is facilitated by dynein motor function since siRNA knockdown of DYNC1H1 increases the amount of HIV-1 p24 associated with cytoplasmic virions PubMed
gag HIV-1 CA uncoating is delayed in the presence of ciliobrevin D, a specific inhibitor of dynein-mediated motor function, indicating that dynein is involved in CA uncoating in cells PubMed
gag Dynein heavy chain depletion causes the accumulation of HIV-1 CA cores in infected cells and relocates their subcellular distribution from the vicinity of the nucleus to the cell periphery PubMed
reverse transcriptase gag-pol Dynein heavy chain (DHC) depletion causes reduced levels of HIV-1 reverse transcribed DNA in infected cells, suggesting RT activity is regulated by DHC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0325, DKFZp686P2245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATP-dependent microtubule motor activity, minus-end-directed IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cytoplasmic mRNA processing body assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of spindle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
minus-end-directed vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle organization NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress granule assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic dynein 1 heavy chain 1
Names
dynein heavy chain, cytosolic
dynein, cytoplasmic, heavy polypeptide 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008777.1 RefSeqGene

    Range
    5001..91271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001376.5NP_001367.2  cytoplasmic dynein 1 heavy chain 1

    See identical proteins and their annotated locations for NP_001367.2

    Status: REVIEWED

    Source sequence(s)
    AB002323, AB290157, AL118558, DB508175
    Consensus CDS
    CCDS9966.1
    UniProtKB/Swiss-Prot
    Q14204
    Related
    ENSP00000348965.4, ENST00000360184.10
    Conserved Domains (2) summary
    pfam08385
    Location:242832
    DHC_N1; Dynein heavy chain, N-terminal region 1
    cl25937
    Location:10464329
    MT; Microtubule-binding stalk of dynein motor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    101964573..102056443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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