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Dync1h1 dynein cytoplasmic 1 heavy chain 1 [ Mus musculus (house mouse) ]

Gene ID: 13424, updated on 10-Oct-2019

Summary

Official Symbol
Dync1h1provided by MGI
Official Full Name
dynein cytoplasmic 1 heavy chain 1provided by MGI
Primary source
MGI:MGI:103147
See related
Ensembl:ENSMUSG00000018707
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Loa; P22; Swl; DHC1; DNCL; DHC1a; Dnec1; Dnecl; MAP1C; Dnchc1; AI894280; mKIAA0325; 9930018I23Rik
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 27.1), cerebellum adult (RPKM 27.0) and 28 other tissues See more
Orthologs

Genomic context

See Dync1h1 in Genome Data Viewer
Location:
12 F1; 12 60.7 cM
Exon count:
77
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110601395..110666944)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (111839605..111905154)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102638940 Neighboring gene protein phosphatase 2, regulatory subunit B', gamma Neighboring gene RIKEN cDNA B930059L03 gene Neighboring gene predicted gene, 35558 Neighboring gene RIKEN cDNA 1700001K19 gene Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (3)  1 citation
  • Radiation induced (1) 
  • Chemically induced (ENU) (2)  1 citation

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, minus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ATP-dependent microtubule motor activity, minus-end-directed ISO
Inferred from Sequence Orthology
more info
 
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
dynein light intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cilium movement IC
Inferred by Curator
more info
PubMed 
cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of spindle localization ISO
Inferred from Sequence Orthology
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
minus-end-directed vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of spindle assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic spindle organization ISO
Inferred from Sequence Orthology
more info
 
retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress granule assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic dynein complex ISM
Inferred from Sequence Model
more info
PubMed 
cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
manchette ISO
Inferred from Sequence Orthology
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytoplasmic dynein 1 heavy chain 1
Names
cytoplasmic dynein heavy chain 1
dynein heavy chain, cytosolic
dynein heavy chain, retrograde transport
dynein, cytoplasmic, heavy chain 1
legs at odd angle
sprawling

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030238.2NP_084514.2  cytoplasmic dynein 1 heavy chain 1

    See identical proteins and their annotated locations for NP_084514.2

    Status: VALIDATED

    Source sequence(s)
    AC152827
    Consensus CDS
    CCDS36559.1
    UniProtKB/Swiss-Prot
    Q9JHU4
    Related
    ENSMUSP00000018851.7, ENSMUST00000018851.13
    Conserved Domains (7) summary
    COG5245
    Location:10444327
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:39204630
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:238830
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13211719
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31993530
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:35593774
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18662103
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p6 C57BL/6J

    Range
    110601395..110666944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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