Format

Send to:

Choose Destination

DDX10 DEAD-box helicase 10 [ Homo sapiens (human) ]

Gene ID: 1662, updated on 6-Jan-2019

Summary

Official Symbol
DDX10provided by HGNC
Official Full Name
DEAD-box helicase 10provided by HGNC
Primary source
HGNC:HGNC:2735
See related
Ensembl:ENSG00000178105 MIM:601235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dbp4; HRH-J8
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.2), kidney (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See DDX10 in Genome Data Viewer
Location:
11q22.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (108665025..108940930)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (108535816..108811650)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267909 Neighboring gene uncharacterized LOC101928561 Neighboring gene exophilin 5 Neighboring gene inversion(11)(p15q22) DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 recombination region Neighboring gene ribosomal protein S2 pseudogene 39 Neighboring gene CYCS pseudogene 29 Neighboring gene RNA, U6 small nuclear 654, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 349

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA knockdown of DDX10 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag siRNA knockdown of DDX10 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA helicase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
anterior head development IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX10
Names
DDX10-NUP98 fusion protein type 2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEAD box protein 10
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
NP_004389.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046987.1 RefSeqGene

    Range
    5001..280906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004398.4NP_004389.2  probable ATP-dependent RNA helicase DDX10

    See identical proteins and their annotated locations for NP_004389.2

    Status: REVIEWED

    Source sequence(s)
    BC091521, DC401755
    Consensus CDS
    CCDS8342.1
    UniProtKB/Swiss-Prot
    Q13206
    Related
    ENSP00000314348.3, ENST00000322536.7
    Conserved Domains (4) summary
    COG0513
    Location:50518
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:288418
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:71275
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:450509
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    108665025..108940930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center