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DDX10 DEAD-box helicase 10 [ Homo sapiens (human) ]

Gene ID: 1662, updated on 2-Nov-2024

Summary

Official Symbol
DDX10provided by HGNC
Official Full Name
DEAD-box helicase 10provided by HGNC
Primary source
HGNC:HGNC:2735
See related
Ensembl:ENSG00000178105 MIM:601235; AllianceGenome:HGNC:2735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dbp4; HRH-J8
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 11.2), kidney (RPKM 9.3) and 25 other tissues See more
Orthologs
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Genomic context

See DDX10 in Genome Data Viewer
Location:
11q22.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (108665069..108940927)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (108672606..108951312)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (108535796..108811654)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902749 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:108353409-108353587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3878 Neighboring gene uncharacterized LOC112267909 Neighboring gene protein O-glucosyltransferase 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:108427339-108427512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5488 Neighboring gene exophilin 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3881 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:108487156-108488355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5490 Neighboring gene inversion(11)(p15q22) DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 recombination region Neighboring gene uncharacterized LOC124902750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5492 Neighboring gene ribosomal protein S2 pseudogene 39 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:108706085-108706835 Neighboring gene CYCS pseudogene 29 Neighboring gene NANOG hESC enhancer GRCh37_chr11:108783920-108784421 Neighboring gene RNA, U6 small nuclear 654, pseudogene Neighboring gene MPRA-validated peak1460 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:108976670-108977588 Neighboring gene Sharpr-MPRA regulatory region 3267 Neighboring gene RNA, 5S ribosomal pseudogene 349

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA knockdown of DDX10 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed
Knockdown of DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
capsid gag siRNA knockdown of DDX10 decreases intra- and extra-cellular HIV CA(p24) from HeLa cells transfected with env-deleted HIV-1 plasmid, a vesicular stomatitis virus glycoprotein plasmid and specific siRNA. Resulting HIV demonstrates decreased infectivity. PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in anterior head development IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX10
Names
DDX10-NUP98 fusion protein type 2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEAD box protein 10
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase)
NP_004389.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046987.1 RefSeqGene

    Range
    5045..280903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004398.4NP_004389.2  probable ATP-dependent RNA helicase DDX10

    See identical proteins and their annotated locations for NP_004389.2

    Status: REVIEWED

    Source sequence(s)
    BC091521, DC401755
    Consensus CDS
    CCDS8342.1
    UniProtKB/Swiss-Prot
    B2RCQ3, Q13206, Q5BJD8
    UniProtKB/TrEMBL
    A0A8I5KSH6
    Related
    ENSP00000314348.3, ENST00000322536.8
    Conserved Domains (2) summary
    COG0513
    Location:50518
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd17941
    Location:80277
    DEADc_DDX10; DEAD-box helicase domain of DEAD box protein 10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    108665069..108940927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    108672606..108951312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)