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CSNK2A1 casein kinase 2 alpha 1 [ Homo sapiens (human) ]

Gene ID: 1457, updated on 24-Nov-2020

Summary

Official Symbol
CSNK2A1provided by HGNC
Official Full Name
casein kinase 2 alpha 1provided by HGNC
Primary source
HGNC:HGNC:2457
See related
Ensembl:ENSG00000101266 MIM:115440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKII; Cka1; Cka2; CK2A1; OCNDS
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]
Expression
Ubiquitous expression in testis (RPKM 33.5), brain (RPKM 25.8) and 25 other tissues See more
Orthologs

Genomic context

See CSNK2A1 in Genome Data Viewer
Location:
20p13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (472498..543790, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (463338..524482, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene TBC1 domain family member 20 Neighboring gene transcription factor 15 Neighboring gene uncharacterized LOC107985387

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, casein kinase 2 alpha 1 polypeptide (CSNK2A1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2A1 is decreased by RRE PubMed
rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chaperone-mediated protein folding TAS
Traceable Author Statement
more info
PubMed 
macroautophagy TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
NuRD complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase CK2 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
casein kinase II subunit alpha
Names
CK2 catalytic subunit alpha
casein kinase 2, alpha 1 polypeptide
casein kinase II alpha 1 polypeptide pseudogene
casein kinase II alpha 1 subunit
protein kinase CK2
NP_001349699.1
NP_001349700.1
NP_001886.1
NP_808227.1
NP_808228.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011970.2 RefSeqGene

    Range
    5049..76341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362770.2NP_001349699.1  casein kinase II subunit alpha isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761
    Consensus CDS
    CCDS13003.1
    Related
    ENSP00000495998.1, ENST00000645623.1
    Conserved Domains (2) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
  2. NM_001362771.2NP_001349700.1  casein kinase II subunit alpha isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761
    Consensus CDS
    CCDS13003.1
    Related
    ENSP00000495248.1, ENST00000643660.1
    Conserved Domains (2) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
  3. NM_001895.4NP_001886.1  casein kinase II subunit alpha isoform a

    See identical proteins and their annotated locations for NP_001886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761, AU133318, BC053532, M55265
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    P68400
    Related
    ENSP00000496569.1, ENST00000646561.1
    Conserved Domains (2) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
  4. NM_177559.3NP_808227.1  casein kinase II subunit alpha isoform a

    See identical proteins and their annotated locations for NP_808227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761, AU132198, BC053532, M55265
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    P68400
    Related
    ENSP00000217244.3, ENST00000217244.9
    Conserved Domains (2) summary
    cd14132
    Location:20325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam12484
    Location:332389
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal
  5. NM_177560.3NP_808228.1  casein kinase II subunit alpha isoform b

    See identical proteins and their annotated locations for NP_808228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR as well as the first coding exon compared to variant 1, resulting in an isoform (b) which is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL049761, AU132198, AY735339, BC053532, M55265
    Consensus CDS
    CCDS13004.1
    UniProtKB/Swiss-Prot
    P68400
    Related
    ENSP00000339247.6, ENST00000349736.10
    Conserved Domains (2) summary
    cd14132
    Location:1189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam12484
    Location:196253
    PE_PPE_C; Polymorphic PE/PPE proteins C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    472498..543790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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